CP Violation in Heavy Neutrino Mediated e−e−→W−W−e^- e^- \to W^- W^-

We consider the reaction $e^- e^- \rightarrow W^- W^-$ mediated by possible heavy neutrino exchange at future LINAC energies of $\sqrt{s}>> 2 m_W$. This reaction is sensitive to CP phases of the neutrino mixing matrices, even at the level of Born amplitudes. Certain integrated cross-sections are shown to have the power to resolve the CP phases when the experimental configurations are varied. Asymmetries sensitive to CP violation (involving initial QED phases) for $e^- e^-$ and $e^+ e^+$ reactions are constructed and their consequences considered.Comment: 9 pages plain Latex and 4 figures available separately as uuencoded figure

Glutathione-Mediated Neuroprotection Against Methylmercury Neurotoxicity in Cortical Culture is Dependent on MRP1

Methylmercury (MeHg) exposure at high concentrations poses significant neurotoxic threat to humans worldwide. The present study investigated the mechanisms of glutathione-mediated attenuation of MeHg neurotoxicity in primary cortical culture. MeHg (5 μM) caused depletion of mono- and disulfide glutathione in neuronal, glial and mixed cultures. Supplementation with exogenous glutathione, specifically glutathione monoethyl ester (GSHME) protected against the MeHg induced neuronal death. MeHg caused increased reactive oxygen species (ROS) formation measured by dichlorodihydrofluorescein (DCF) fluorescence with an early increase at 30 min and a late increase at 6 h. This oxidative stress was prevented by the presence of either GSHME or the free radical scavenger, trolox. While trolox was capable of quenching the ROS, it showed no neuroprotection. Exposure to MeHg at subtoxic concentrations (3 μM) caused an increase in system xc− mediated 14C-cystine uptake that was blocked by the protein synthesis inhibitor, cycloheximide (CHX). Interestingly, blockade of the early ROS burst prevented the functional upregulation of system xc−. Inhibition of multidrug resistance protein-1 (MRP1) potentiated MeHg neurotoxicity and increased cellular MeHg. Taken together, these data suggest glutathione offers neuroprotection against MeHg toxicity in a manner dependent on MRP1-mediated efflux

Data management procedures for Tiepoint Registration, pre and post processing, and ICD116

The data management procedures for tiepoint registration, pre and post processing, and "ICD116' are described. With each procedure description, the pertinent execs are listed and purposes defined. An example run of each of the 32 execs is included with user inputs identified

Vector magnetic field microscopy using nitrogen vacancy centers in diamond

The localized spin triplet ground state of a nitrogen vacancy (NV) center in diamond can be used in atomic-scale detection of local magnetic fields. Here we present a technique using these defects in diamond to image fields around magnetic structures. We extract the local magnetic field vector by probing resonant transitions of the four fixed tetrahedral NV orientations. In combination with confocal microscopy techniques, we construct a 2-dimensional image of the local magnetic field vectors. Measurements are done in external fields less than 50 G and under ambient conditions.Comment: 9 pages, 3 figure

Axisymmetric Solutions to Einstein Field Equations via Integral Transforms

In this paper, we present new axisymmetric and reflection symmetric vacuum solutions to the Einstein field equations. They are obtained using the Hankel integral transform method and all three solutions exhibit naked singularities. Our results further reinforce the importance and special character of axisymmetric solutions in general relativity and highlight the role of integral transforms methods in solving complex problems in this field. We compare our results to already existing solutions which exhibit the same type of singularities. In this context we notice that most known axial-symmetric solutions possess naked singularities. A discussion of characteristic features of the newly found metrics, e.g., blueshift and the geometry of the singularities, is given.Comment: 20 pages, 6 figure