2,404 research outputs found
Memory and cognitive control in an integrated theory of language processing.
Pickering and Garrod’s integrated model of production and comprehension includes no explicit role for non-linguistic cognitive processes. Yet, how domain-general cognitive functions contribute to language processing has become clearer with well-specified theories and supporting data. We therefore believe that their account can benefit by incorporating functions like working memory and cognitive control into a unified model of language processing
Boolean Models of Bistable Biological Systems
This paper presents an algorithm for approximating certain types of dynamical
systems given by a system of ordinary delay differential equations by a Boolean
network model. Often Boolean models are much simpler to understand than complex
differential equations models. The motivation for this work comes from
mathematical systems biology. While Boolean mechanisms do not provide
information about exact concentration rates or time scales, they are often
sufficient to capture steady states and other key dynamics. Due to their
intuitive nature, such models are very appealing to researchers in the life
sciences. This paper is focused on dynamical systems that exhibit bistability
and are desc ribedby delay equations. It is shown that if a certain motif
including a feedback loop is present in the wiring diagram of the system, the
Boolean model captures the bistability of molecular switches. The method is
appl ied to two examples from biology, the lac operon and the phage lambda
lysis/lysogeny switch
On the principal bifurcation branch of a third order nonlinear long-wave equation
We study the principal bifurcation curve of a third order equation which
describes the nonlinear evolution of several systems with a long--wavelength
instability. We show that the main bifurcation branch can be derived from a
variational principle. This allows to obtain a close estimate of the complete
branch. In particular, when the bifurcation is subcritical, the large amplitude
stable branch can be found in a simple manner.Comment: 11 pages, 3 figure
LR characterization of chirotopes of finite planar families of pairwise disjoint convex bodies
We extend the classical LR characterization of chirotopes of finite planar
families of points to chirotopes of finite planar families of pairwise disjoint
convex bodies: a map \c{hi} on the set of 3-subsets of a finite set I is a
chirotope of finite planar families of pairwise disjoint convex bodies if and
only if for every 3-, 4-, and 5-subset J of I the restriction of \c{hi} to the
set of 3-subsets of J is a chirotope of finite planar families of pairwise
disjoint convex bodies. Our main tool is the polarity map, i.e., the map that
assigns to a convex body the set of lines missing its interior, from which we
derive the key notion of arrangements of double pseudolines, introduced for the
first time in this paper.Comment: 100 pages, 73 figures; accepted manuscript versio
Longtime behavior of nonlocal Cahn-Hilliard equations
Here we consider the nonlocal Cahn-Hilliard equation with constant mobility
in a bounded domain. We prove that the associated dynamical system has an
exponential attractor, provided that the potential is regular. In order to do
that a crucial step is showing the eventual boundedness of the order parameter
uniformly with respect to the initial datum. This is obtained through an
Alikakos-Moser type argument. We establish a similar result for the viscous
nonlocal Cahn-Hilliard equation with singular (e.g., logarithmic) potential. In
this case the validity of the so-called separation property is crucial. We also
discuss the convergence of a solution to a single stationary state. The
separation property in the nonviscous case is known to hold when the mobility
degenerates at the pure phases in a proper way and the potential is of
logarithmic type. Thus, the existence of an exponential attractor can be proven
in this case as well
Cost-effectiveness of financial incentives to promote adherence to depot antipsychotic medication: economic evaluation of a cluster-randomised controlled trial
Background: Offering a modest financial incentive to people with psychosis can promote adherence to depot antipsychotic medication, but the cost-effectiveness of this approach has not been examined. Methods: Economic evaluation within a pragmatic cluster-randomised controlled trial. 141 patients under the care of 73 teams (clusters) were randomised to intervention or control; 138 patients with diagnoses of schizophrenia, schizo-affective disorder or bipolar disorder participated. Intervention participants received £15 per depot injection over 12 months, additional to usual acute, mental and community primary health services. The control group received usual health services. Main outcome measures: incremental cost per 20% increase in adherence to depot antipsychotic medication; incremental cost of ‘good’ adherence (defined as taking at least 95% of the prescribed number of depot medications over the intervention period). Findings: Economic and outcome data for baseline and 12-month follow-up were available for 117 participants. The adjusted difference in adherence between groups was 12.2% (73.4% control vs. 85.6% intervention); the adjusted costs difference was £598 (95% CI -£4 533, £5 730). The extra cost per patient to increase adherence to depot medications by 20% was £982 (95% CI -£8 020, £14 000). The extra cost per patient of achieving 'good' adherence was £2 950 (CI -£19 400, £27 800). Probability of cost-effectiveness exceeded 97.5%at willingness-to-pay values of £14 000 for a 20% increase in adherence and £27 800 for good adherence. Interpretation: Offering a modest financial incentive to people with psychosis is cost-effective in promoting adherence to depot antipsychotic medication. Direct healthcare costs (including costs of the financial incentive) are unlikely to be increased by this intervention. Trial Registration: ISRCTN.com 7776928
UK science press officers, professional vision and the generation of expectations
Science press officers can play an integral role in helping promote expectations and hype about biomedical research. Using this as a starting point, this article draws on interviews with 10 UK-based science press officers, which explored how they view their role as science reporters and as generators of expectations. Using Goodwin’s notion of ‘professional vision’, we argue that science press officers have a specific professional vision that shapes how they produce biomedical press releases, engage in promotion of biomedical research and make sense of hype. We discuss how these insights can contribute to the sociology of expectations, as well as inform responsible science communication.This project was funded by the Wellcome Trust (Wellcome Trust Biomedical Strategic Award 086034)
Measuring energy dependent polarization in soft gamma-rays using Compton scattering in PoGOLite
Linear polarization in X- and gamma-rays is an important diagnostic of many
astrophysical sources, foremost giving information about their geometry,
magnetic fields, and radiation mechanisms. However, very few X-ray polarization
measurements have been made, and then only mono-energetic detections, whilst
several objects are assumed to have energy dependent polarization signatures.
In this paper we investigate whether detection of energy dependent polarization
from cosmic sources is possible using the Compton technique, in particular with
the proposed PoGOLite balloon-experiment, in the 25-100 keV range. We use
Geant4 simulations of a PoGOLite model and input photon spectra based on Cygnus
X-1 and accreting magnetic pulsars (100 mCrab). Effective observing times of 6
and 35 hours were simulated, corresponding to a standard and a long duration
flight respectively. Both smooth and sharp energy variations of the
polarization are investigated and compared to constant polarization signals
using chi-square statistics. We can reject constant polarization, with energy,
for the Cygnus X-1 spectrum (in the hard state), if the reflected component is
assumed to be completely polarized, whereas the distinction cannot be made for
weaker polarization. For the accreting pulsar, constant polarization can be
rejected in the case of polarization in a narrow energy band with at least 50%
polarization, and similarly for a negative step distribution from 30% to 0%
polarization.Comment: 11 pages, 12 figures; updated to match version accepted for
publication in Astroparticle Physics (only minor changes
Applying a User-centred Approach to Interactive Visualization Design
Analysing users in their context of work and finding out how and why they use different information resources is essential to provide interactive visualisation systems that match their goals and needs. Designers should actively involve the intended users throughout the whole process. This chapter presents a user-centered approach for the design of interactive visualisation systems. We describe three phases of the iterative visualisation design process: the early envisioning phase, the global specification hase, and the detailed specification phase. The whole design cycle is repeated until some criterion of success is reached. We discuss different techniques for the analysis of users, their tasks and domain. Subsequently, the design of prototypes and evaluation methods in visualisation practice are presented. Finally, we discuss the practical challenges in design and evaluation of collaborative visualisation environments. Our own case studies and those of others are used throughout the whole chapter to illustrate various approaches
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