INTERCONNECTION BETWEEN MIXED-HANDEDNESS, DIGIT RATIOS AND HAND AND FOOT MINOR ANOMALIES IN PREDICTING SCHIZOPHRENIA

Background: According to the neurodevelopmental theory, brain structuring early markers could be seen in different body parts as minor physical anomalies. Alongside minor physical anomalies, handedness and index to ring finger ratio are brain development indicators, specifically brain lateralization. Studies are consentient about the association of these findings with schizophrenia, though there is inconsistency about individual anatomical regions\u27 contribution. We proposed that handedness in combination with morphological indicators of early brain development could be sensitive and specific in predicting schizophrenia status. Subjects and methods: Within the list for the assessment of schizophrenia patients and normal controls of the Caucasian race were seven categorical minor physical anomalies of hand and feet, handedness, and index to ring finger ratio. In this cross-sectional study the examinees were recruited from January 2012 to December 2015. Results: Forced-entry binary logistic regression model correctly classified 86.5% of patients and 99.2% of the comparison subjects with a 92.8% overall accuracy. Mixed-handedness, hyperconvex fingernails, big gap between 1st and 2nd toe, and partial syndactyly of 2nd and 3rd toe made a significant independent contribution to the patient-control prediction group status. Furthermore, these items showed a significant correlation with the predictors of the head from the previous study. Conclusion: Briefly, the limb components, assessed independently of other body regions, proved to be worthy as schizophrenia predictors

Short Intramolecular O···O Contact in Some o-Dialkoxybenzene Derivatives Generates Efficient Hydrogen Bonding Acceptor Area

Statistical analysis of data extracted from the Cambridge Structural Database (CSD) has been used to investigate the crystal structure properties of odialkoxybenzene derivatives, compounds containing two ether oxygen acceptors in ortho positions of benzene ring. It has been shown that in more than 90% of cases, the fragment has predictable geometrical characteristics where the two ether oxygens form short interatomic O center dot center dot center dot O contact (2.57 A in average), while O-substitutents take trans position, both approximately coplanar with the benzene ring. Such arrangement of oxygen acceptors produces a large and uniform area of the negative electrostatic potential suitable for multiple hydrogen bonding. The acceptor abilities of the O center dot center dot center dot O system have been investigated by the statistical CSD analysis. The ab initio estimation of the interaction energy in the dimer of o-dimethoxybenzene (DMB) and H2O, employed as a model system, is achieved via high-level electron correlation CCSD(T) calculation with the complete basis set extrapolation. The interaction energy is estimated to be 6.5 kcal/mol. The results indicate the existence of a very flat potential the region between methoxy oxygens and that DMB water is a highly flexible system. The structural role of the O center dot center dot center dot O acceptor system is particularly interesting considering its ability to form multiple hydrogen bondingThe peer-reviewed version: [https://cer.ihtm.bg.ac.rs/handle/123456789/4283]The supplementary information: [https://cer.ihtm.bg.ac.rs/handle/123456789/4479

La densité électronique : un outil pour étudier les composés contenant des métaux de transition

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Experimental charge density evidence for the existence of high polarizability of the electron density of the free electron pairs on the sulfur atom of the thioureido group, NH-C(S)-NH2, induced by N-H center dot center dot S and C-H center dot center dot S interactions

International audienceThe experimental charge density study of salicylaldehyde thiosemicarbazone (SalTSC) has been performed. The analysis of the crystal packing revealed that the sulfur atom is simultaneously engaged in six hydrogen bonding interactions, two of N-H…S, leading to a dimmer, and four of C-H…S type. It has been established that the deformation density of the free electron pairs on the sulfur atom is inhomogeneously distributed within a torus. A relationship found between the deformation of the torus and the space directionality of the surrounding donor groups suggests that the sulfur atom of the thioureide moiety easily adjusts to the environment in order to increase the number of stabilizing contacts. CSD study of the compounds containing thioureido -N-C(=S)-N fragment confirmed the experimental results for SalTSC, i.e. about 60% of the analyzed crystal structures form dimer trough N-H…S interactions while in about 50% of crystal structures the S atom forms four of more D-H…S intermolecular interactions (D = C, N and O)

Endovenous laser ablation of the great saphenous vein in patients with von willebrand disease

Introduction Patients with von Willebrand disease have a high risk of bleeding during the surgical treatment of varicose veins. Endovenous laser ablation (EVLA) of the great saphenous vein (GSV) is a minimally invasive treatment for saphenofemoral junction incompetence. Th e number of complications and relapse rate of EVLA are lower than in those of conventional surgical treatment. Case presentation A patient with great saphenous vein insuffi ciency, von Willebrand disease and hypofi brinogenemia successfully underwent endovenous laser ablation. Replacement therapy with cryoprecipitate was administered preoperatively and postoperatively. Th e surgical procedure and postoperative course were unremarkable. Conclusion In patients with von Willebrand disease and other coagulation disorders, endovenous laser ablation is a safe and effective treatment. Th e use of minimally invasive treatment, the adequate correction of haemostasis, and close cooperation between the haematologist, anaesthesiologist and endovascular surgeon reduce the risk of bleeding

4-[(4-Methylphenyl)sulfanyl]butan-2-one

In the title compound, C11H14OS, all non-H atoms are essentially coplanar, with a mean deviation of 0.023 Å. In the crystal, centrosymmetrically related molecules are weakly connected into dimers by pairs of C - H⋯O interactions. The dimers are further linked along the a axis by weak C - H⋯π and C - H⋯S interactions

3-(3-Acetylanilino)-1-ferrocenylpropan-1-one

The title ferrocene-containing Mannich base, [Fe(C5H 5)(C16H16NO2)], crystallizes with two independent molecules (A and B) in the asymmetric unit. Molecules A and B have similar conformations. The dihedral angles between the best planes of the benzene and substituted cyclopentadienyl rings are 88.59 (9) and 84.39 (10)° in A and B, respectively. In the crystal, the independent molecules form centrosymmetric dimers via corresponding N - H⋯O hydrogen bonds. The dimers further arrange via C - H⋯π and C - H⋯O interactions. There are no significant interactions between the A and B molecules. © 2012 International Union of Crystallography