Learning processes and economic returns in European Cohesion policy

This paper evaluates whether the learning mechanisms of the European Cohesion policy have contributed to improve the economic impact of Structural Fund expenditure over time. It intends to show whether the evolution of the policy in response to greater internal monitoring and consultation and external scrutiny and criticism has resulted in a more efficient and better targeted Cohesion policy. This is tested using an econometric model which evaluates the effect of Structural Fund expenditure on the growth of regional GDP per capita – conditional on factor endowments, institutional quality and initial conditions – during the last programming periods for which full sets of data are available (1994-1999 and 2000-2006). The results of the analysis unveil an increase in the effectiveness of the policy in successive periods. This positive association is robust to controlling for the level of development of the country and the relative economic position of a region within a country. The results also show that, when structural factors are taken into consideration, Structural Fund investment tends to yield higher returns in better-off countries and wealthier regions within countries.Cohesion; regional development; economic growth, GDP per capita; regions; European Union

Procesos de aprendizaje y rendimiento económico de la Política de Cohesión Europea

Este artículo evalúa hasta qué punto los mecanismos de aprendizaje de la política de Cohesión europea han contribuido a mejorar el impacto económico de los Fondos Estructurales. El objetivo es ver si los cambios introducidos en la política en respuesta a la evaluación interna y a las críticas externas han dado lugar a una política mejor y más eficaz. Para ello se utiliza un método econométrico que evalúa el efecto de los Fondos Estructurales sobre el crecimiento regional del PIB per cápita —condicionado por la dotación de los factores, la calidad de las instituciones y las condiciones iniciales de cada región— durante los dos últimos periodos de programación para los que existen datos completos (1994-1999 y 2000-2006). Los resultados del análisis indican una mejora de la eficacia de la política en el segundo periodo de programación. Esta asociación positiva es robusta a la introducción de controles ligados al nivel de desarrollo del país y de la posición de cada una de las regiones en el interior del país. Los resultados muestran también que, cuando se tienen en cuenta factores estructurales, la inversión en Fondos Estructurales obtiene mejores rendimientos en países con niveles de riqueza más altos y en las regiones más ricas en el interior de cada país.This paper evaluates whether the learning mechanisms of the European Cohesion policy have contributed to improve the economic impact of Structural Fund expenditure over time. It analyses whether the evolution of the policy in response to greater internal monitoring and external scrutiny has resulted in a more efficient and better targeted Cohesion policy. This is tested using an econometric model which evaluates the effect of Structural Fund expenditure on the growth of regional GDP per capita —conditional on factor endowments, institutional quality and initial conditions— during the last programming periods for which full sets of data are available (1994-1999 and 2000-2006). The results of the analysis unveil an increase in the effectiveness of the policy in successive periods. This positive association is robust to controlling for the level of development of the country and the relative economic position of a region within a country. The results also show that, when structural factors are taken into consideration, Structural Fund investment tends to yield higher returns in better-off countries and wealthier regions within countries

Static calculation of single family house on Jelični vrh

This thesis presents the design and static analysis of the load-bearing construction for the selected\ud single-family house, which is located on Jelični Vrh in Idrija. Part of the thesis refers to the foundation\ud and the design of the construction pit.\ud I provided controls for ultimate limiting states for load-bearing and limiting states for usability when I\ud was dimensioning the supporting structure of the roof and when I was analysing the reinforced\ud concrete plate and masonry. I took into consideration multiple effects such as permanent impacts,\ud impacts of imposed loads, snow load, wind load and also seismic effect.\ud For the analysis of horizontal structure I made an idealized mathematical model with the SAP2000\ud program, which is based on finite element method. As a result I obtained the necessary amount of\ud longitudinal rebar. For the analysis of the roof supporting structure I also made an idealized\ud mathematical model with the SAP2000 program. I made the appropriate checks using the standards.\ud The analysis of the masonry was performed with the help of the architectural drawings and appropriate\ud checks using the standards and other manuals.\ud I chose the appropriate foundation and design of the construction pit on the basis of the geotechnical\ud characteristics of soils, which were obtained through the field research. I performed global stability\ud analysis using the Slide program and on the basis of the required safety I chose the appropriate\ud implementation

Production of catalog for socks

Rdeča nit diplomskega dela je raziskovanje in analiziranje, kako izdelati dober in zanimiv katalog z vzorci nogavic. Katalog predstavlja podjetje, zato mora le-ta biti unikaten in izstopati, najbolj bistveno pa je seveda, da predstavi produkte na zanimiv in jasen način. Katalog bo vseboval slike izdelkov in njihove opise ter podatke o podjetju. Iz teh podatkov nato naročnik ali kupec izve, kaj ima podjetje na voljo. V teoretičnem delu je predstavljeno kaj katalog je, kakšne vrste katalogov poznamo in kateri so tisti glavni in privlačni deli kataloga, ki jih uporabnik najprej opazi. Cilj diplomskega dela je raziskati katalog, da bo vsak bralec točno vedel, kaj katalog obsega, ter izdelati privlačen vzorčni katalog za nogavice. V eksperimentalnem delu je predstavljeno, kako se je v fotografskem studiu pod določenimi pogoji fotografiralo vse vzorce nogavic na umetni nogi ter kasneje oblikovalo katalog. Katalog bo na koncu tudi realiziran (vendar v širši obliki) ter uporabljen kot promocija za podjetij Proteks in Noteks. Na koncu bo izdelana tudi anketa, v kateri se bodo anketiranci odločali, kateri del v katalogu jim je najbolj zanimiv oz. privlačen. Rezultat bo testni katalog izdelkov, ki se bo v bodoče še razvijal in uporabljal na tržišču.The main point of this thesis is the research and analysis of how to make a good and interesting catalog with stocking patterns. The catalog is a presentation of the company and therefore has to be unique and must stand out, but most importantly it has to present the products in an interesting and clear way. Pictures of products, descriptions of products and the company’s details will be included in the catalog. This information provides the customer with knowledge of what the company has to offer. In the theoretical part, there will be a discussion about what a catalog is, which types of catalogs exist and which are the main and attractive parts of a catalog that the user notices first. The goal of this thesis is to do a research about catalogs and for every reader to know what the catalog includes and how to create an attractive pattern catalog for stockings. In the practical or experimental part, a photographing in a photo-studio will take place. The photographing of all stocking patterns on a mannequin leg under certain conditions will later help with the design of the catalog. The catalog will be later printed (in a larger version) and used for company promotions for Proteks and Noteks. Followed by a survey in which the interviewee will decide, which part of the catalog he or she found the most interesting or attractive. The result will be a test-catalog of products, which will be developed further in the future and used on the market

Experiences with Glofitamab Administration following CAR T Therapy in Patients with Relapsed Mantle Cell Lymphoma.

Mantle cell lymphoma (MCL) is a rare type of B-cell Non-Hodgkin lymphoma (NHL) affecting predominantly male patients. While complete remissions following first-line treatment are frequent, most patients ultimately relapse, with a usually aggressive further disease course. The use of cytarabine-comprising induction chemotherapy and autologous stem cell transplantation, Rituximab maintenance, Bruton's tyrosine kinase (BTK) inhibitors and CAR T therapy has substantially improved survival. Still, options for patients relapsing after CAR T therapy are limited and recommendations for the treatment of these patients are lacking. We report two cases of patients with mantle cell lymphoma who relapsed after CAR T therapy and were treated with the bispecific CD20/CD3 T cell engaging antibody glofitamab. Both patients showed marked increases of circulating CAR T cells and objective responses after glofitamab administration. Therapy was tolerated without relevant side effects in both patients. One patient completed all 12 planned cycles of glofitamab therapy and was alive and without clinical progression at the last follow-up. The second patient declined further treatment after the first cycle and succumbed to disease progression. We review the literature and investigate possible mechanisms involved in the observed responses after administration of glofitamab, such as proliferation of CAR T cells, anti-tumor effects of the bispecific antibody and the role of other possibly contributing factors. Therapy with bispecific antibodies might offer an effective and well-tolerated option for patients with mantle cell lymphoma relapsing after CAR T therapy

Pozicioniranje in kontrola kakovosti mamograma

Izhodišča. Pravilno pozicioniranje je predpogoj za zagotavljanje kakovosti mamografskih slik. Zato je pomembno, da dobro poznamo anatomijo in tehnike pozicioniranja, slikanja in razvijanja. Zaključki. Da bi dosegli optimalen prikaz tkiv, rnorarno pravilno nastaviti nosilec kasete in kompresorij ter izkoristiti premakljivost dojk, pomembna pa je tudi pravilna uporaba aparatur.Ob izvajanju mamografije moramo nujno upoštevati kriterije za kontrolo kakovosti. Pri tem nam pomaga pravilnik o pogojih, ki jih morajo izpolnjevati primarni centri za dojke v Republiki Sloveniji, ter evropske smernice. S kontrolo kakovosti bomo u Sloveniji zvišali kvaliteto in s tem prispevali k čirn zgodnejšemu odkrivanju sprememb na dojkah

Rebound Thrombocytosis after Induction Chemotherapy is a Strong Biomarker for Favorable Outcome in AML Patients

https://scholarlycommons.pacific.edu/pacifican/1478/thumbnail.jp

A cross-sectional study of the public health response to non-alcoholic fatty liver disease in Europe

Background & Aims: Non-alcoholic fatty liver disease (NAFLD) is a growing public health problem worldwide and has become an important field of biomedical inquiry. We aimed to determine whether European countries have mounted an adequate public health response to NAFLD and non-alcoholic steatohepatitis (NASH). Methods: In 2018 and 2019, NAFLD experts in 29 European countries completed an English-language survey on policies, guidelines, awareness, monitoring, diagnosis and clinical assessment in their country. The data were compiled, quality checked against existing official documents and reported descriptively. Results: None of the 29 participating countries had written strategies or action plans for NAFLD. Two countries (7%) had mentions of NAFLD or NASH in related existing strategies (obesity and alcohol). Ten (34%) reported having national clinical guidelines specifically addressing NAFLD and, upon diagnosis, all included recommendations for the assessment of diabetes and liver cirrhosis. Eleven countries (38%) recommended screening for NAFLD in all patients with either diabetes, obesity and/or metabolic syndrome. Five countries (17%) had referral algorithms for follow-up and specialist referral in primary care, and 7 (24%) reported structured lifestyle programmes aimed at NAFLD. Seven (24%) had funded awareness campaigns that specifically included prevention of liver disease. Four countries (14%) reported having civil society groups which address NAFLD and 3 countries (10%) had national registries that include NAFLD. Conclusions: We found that a comprehensive public health response to NAFLD is lacking in the surveyed European countries. This includes policy in the form of a strategy, clinical guidelines, awareness campaigns, civil society involvement, and health systems organisation, including registries. Lay summary: We conducted a survey on non-alcoholic fatty liver disease with experts in European countries, coupled with data extracted from official documents on policies, clinical guidelines, awareness, and monitoring. We found a general lack of national policies, awareness campaigns and civil society involvement, and few epidemiological registries.International Liver Foundation through grants from Gilead Sciences Europe Ltd., Allergan Pharmaceutical International Ltd., Bristol-Myers-Squibb Company, Pfizer Inc., and Resoundant Inc. JVL is a Miguel Servet-funded researcher at ISGlobal, Hospital Clínic, University of Barcelona. QMA and VR are members of the EPoS (Elucidating Pathways of Steatohepatitis) consortium funded by the Horizon 2020 Framework Program of the European Union under Grant Agreement 634413. QMA, VR, HCP, ME, MRG, HCP are members of the LITMUS (Liver Investigation: Testing Marker Utility in Steatohepatitis) consortium funded by the IMI2 Program of the European Union under Grant Agreement 777377. QMA is a Newcastle NIHR Biomedical Research Centre investigator