Diagnosis and treatment of extraction sockets in preparation for implant placement: report of three cases

This article addresses diagnostic parameters that should be assessed in the treatment of extraction sockets with dental implant placement by presenting three case reports that emphasize the relevance of the amount of remaining bone walls. Diagnosis was based on the analysis of clinical and radiographic parameters (e.g.: bone defect morphology, remaining bone volume, presence of infections on the receptor site). Case 1 presents a 5-wall defect in the maxillary right central incisor region with severe root resorption, which was treated with immediate implant placement. Cases 2 and 3 present, respectively, two- and three-wall bone defects that did not have indication for immediate implants. These cases were first submitted to a guided bone regeneration (GBR) procedure with bone graft biomaterial and membrane barriers, and the implants were installed in a second surgical procedure. The analysis of the preoperative periodontal condition of the adjacent teeth and bone defect morphology is extremely important because these factors determine the choice between immediate implant or GBR treatment followed by implant installation in a subsequent intervention.Este artigo aborda os parâmetros clínicos que devem ser observados no diagnóstico e tratamento de alvéolos de extração por meio da instalação de implantes através da apresentação de casos clínicos, enfatizando a importância do número de paredes ósseas. O diagnóstico baseou-se na análise de parâmetros clínicos e radiográficos (p. ex: morfologia do defeito ósseo, volume ósseo remanescente, presença de infecção na área receptora). O Caso 1 apresenta um defeito de 5 paredes relacionado a um incisivo central superior direito que apresentava extensa reabsorção radicular e foi tratado através da técnica de implante imediato. Os Casos 2 e 3 consistem em defeitos de 2 e 3 paredes ósseas presentes, respectivamente, que inicialmente não devem ser tratados com implantes imediatos, e, por isso, foram submetidos inicialmente ao procedimento de regeneração óssea guiada, com uso de biomateriais para enxertia e barreiras de membrana, para receberem implantes numa segunda etapa cirúrgica. A avaliação prévia das condições periodontais dos dentes adjacentes e da morfologia do defeito ósseo são extremamente importantes, uma vez que determinam se determinada área será tratada pela técnica de ROG ou pela técnica de implantes imediatos

Clinical attachment loss and molecular profile of inflamed sites before treatment

Objective: To monitor early periodontal disease progression and to investigate clinical and molecular profile of inflamed sites by means of crevicular fluid and gingival biopsy analysis. Methodology: Eighty-one samples of twenty-seven periodontitis subjects and periodontally healthy individuals were collected for the study. Measurements of clinical parameters were recorded at day −15, baseline and 2 months after basic periodontal treatment aiming at monitoring early variations ofthe clinical attachment level. Saliva, crevicular fluid and gingival biopsies were harvested from clinically inflamed and non-inflamed sites from periodontal patients and from control sites of healthy patients for the assessment of IL-10, MMP-8, VEGF, RANKL, OPG and TGF-β1 protein and gene expression levels. Results:Baseline IL-10 protein levels from inflamed sites were higher in comparison to both non-inflamed and control sites (p<0.05). Higher expression of mRNA for IL-10, RANK-L, OPG, e TGF-β1 were also observed in inflamed sites at day −15 prior treatment (p<0.05). After the periodontal treatment and the resolution of inflammation, seventeen percent of evaluated sites still showed clinically detectable attachment loss without significant differences in the molecular profile. Conclusions: Clinical attachment loss is a negative event that may occur even after successful basic periodontal therapy, but it is small and limited to a small percentage of sites. Elevated inflammation markers of inflamed sites from disease patients reduced to the mean levels of those observed in healthy subjects after successful basic periodontal therapy. Significantly elevated both gene and protein levels of IL-10 in inflamed sites prior treatment confirms its modulatory role in the disease status