Voltage controlled sub-THz detection with gated planar asymmetric nanochannels

[EN]This letter reports on room temperature sub-THz detection using self-switching diodes based on an AlGaN/GaN heterostructure on a Si substrate. By means of free-space measurements at 300 GHz, we demonstrate that the responsivity and noise equivalent power (NEP) of sub-THz detectors based on planar asymmetric nanochannels can be improved and voltage controlled by means of a top gate electrode. A simple quasi-static model based on the DC measurements of the current-voltage curves is able to predict the role of the gate bias in its performance. The best values of voltage responsivity and NEP are achieved when the gate bias approaches the threshold voltage, around 600 V/W and 50 pW/Hz1/2, respectively. A good agreement is found between modeled results and those obtained from RF measurements under probes at low frequency (900MHz) and in free-space at 300 GHz

Broadening and exploiting the genetic base of white lupin

White lupin is a European crop with a long history of domestication and high potential interest for high-protein food or feedstuff. This report aims to summarize the research steps that were undertaken to (i) verify the extent of genetic diversity exploited by modern breeding, (ii) identify elite bitter-seed landraces and sweet-seed germplasm aimed to broaden the genetic base for European breeding, (iii) assess the genetic variation for tolerance to key abiotic stresses in the germplasm of the novel genetic base, and (iv) verify the potential of genomic models based on genotyping-bysequencing (GBS) SNP data to select simultaneously and cost-efficiently for some complex traits. Molecular diversity patterns of 83 landraces from nine major historical cropping regions and 15 commercial varieties confirmed that modern plant breeding exploited only a modest part of the crop genetic variation. Germplasm evaluation experiments for adaptation to severe drought or calcareous soil revealed substantial genetic variation (Annicchiarico and Thami-Alami, 2012; Annicchiarico et al., 2018), which, along with other information, was exploited to identify four elite landraces and four elite, sweet-seed lines that acted as parents of a broadly-based population. Some 144 sweet-seed lines extracted from this population were evaluated for grain yield under severe drought in a managed environment of Italy and for adaptation to moderately calcareous soil in a spring-sown environment of the Netherlands and an autumn-sown environment of Greece. We report on the observed line variation for these traits, and on the construction of genomic selection models and their ability to predict the line adaptation to drought or lime soil based on cross validations. Genome-enabled models may be used also to select for tolerance to anthracnose and the sweet-seed trait

Differentiation stage of myeloma plasma cells: biological and clinical significance

[EN] The notion that plasma cells (PCs) are terminally differentiated has prevented intensive research in multiple myeloma (MM) about their phenotypic plasticity and differentiation. Here, we demonstrated in healthy individuals (n = 20) that the CD19 − CD81 expression axis identifies three bone marrow (BM)PC subsets with distinct age-prevalence, proliferation, replication-history, immunoglobulin-production, and phenotype, consistent with progressively increased differentiation from CD19+CD81+ into CD19 − CD81+ and CD19 − CD81 − BMPCs. Afterwards, we demonstrated in 225 newly diagnosed MM patients that, comparing to normal BMPC counterparts, 59% had fully differentiated (CD19 − CD81 −) clones, 38% intermediate-differentiated (CD19 − CD81+) and 3% less-differentiated (CD19+CD81+) clones. The latter patients had dismal outcome, and PC differentiation emerged as an independent prognostic marker for progression-free (HR: 1.7; P = 0.005) and overall survival (HR: 2.1; P = 0.006). Longitudinal comparison of diagnostic vs minimal-residual-disease samples (n = 40) unraveled that in 20% of patients, less-differentiated PCs subclones become enriched after therapy-induced pressure. We also revealed that CD81 expression is epigenetically regulated, that less-differentiated clonal PCs retain high expression of genes related to preceding B-cell stages (for example: PAX5), and show distinct mutation profile vs fully differentiated PC clones within individual patients. Together, we shed new light into PC plasticity and demonstrated that MM patients harbouring less-differentiated PCs have dismal survival, which might be related to higher chemoresistant potential plus different molecular and genomic profiles

El puzzle de los pentominos

Se presenta una unidad didáctica de la asignatura de tecnología del primer curso de bachillerato general. La idea fue la creación de un puzzle de doce figuras, con su correspondiente terreno de juego y todo recogido en un estuche. Se utilizaron la madera y la cartulina como materiales de trabajo, y el lápiz, regla, segueta, lima y lija como instrumentos para construirlos. Los objetivos principales de esta actividad fueron: diseñar un objeto de uso personal de no difícil construcción, conocer las principales propiedades de las maderas utilizadas en el proyecto, conocer y aplicar las fases en el desarrollo del proyecto y evaluar el objeto de acuerdo a las normas de seguridad y uso de las máquinas y herramientas. Primero se presentó la unidad didáctica: objetivos, esquema de trabajo y plazos de realización; luego se realizaron en grupo los bocetos de las figuras que componían el juego; se realizaron a escala las figuras en cartulina; se hicieron los planos correspondientes y se calculó el material necesario y el presupuesto y finalmente se valoró la unidad didáctica. La actividad, en líneas generales, fue motivadora para la mayoría de los alumnos. El aspecto lúdico y la conciencia de que una vez acabado sería para uso particular de cada alumno contribuyo a ello.Castilla y LeónES