164 research outputs found

    Representation in Westminster in the 1990s : The ghost of Edmund Burke

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    Why are 'trustee' notions of representation still invoked in the UK House of Commons in the 1990s? In answering this question this article analyses the premises of Burkean theory and the arguments that these premises are of little relevance in the late twentieth century. Despite these dismissals of trusteeship, Burkean ideas are still articulated in the Commons some 200 years after they were first voiced. The idea of trusteeship can prove extremely useful to justify the actions of representatives when those actions conflict with constituency 'opinion', party policy or the wishes of interest groups. Examples of the occasions when Burkean notions have been invoked in the 1990s are provided

    In search of lost time: When people start an exercise program, where does the time come from? A randomized controlled trial

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    The objective of this study was to investigate changes in use of time when undertaking a structured exercise program.This study used a randomized, multi-arm, controlled trial design.A total of 129 insufficiently active adults aged 18-60 years were recruited and randomly allocated to one of three groups, a Moderate or Extensive six-week exercise group (150 and 300 additional minutes of exercise per week, respectively) or a Control group. Prescribed exercise was accumulated through both group and individual sessions. Use of time was measured at baseline and end-program using the Multimedia Activity Recall for Children and Adults, a computerized 24-h recall instrument. Daily minutes of activity in activity domains and energy expenditure zones were determined.Relative to changes in the control group, daily time spent in the physical activity [F (2, 108)=20.21,

    Pasture age impacts soil fungal composition while bacteria respond to soil chemistry

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    Pasture is a globally important managed habitat providing both food and income. The way in which it is managed leads to a wide range of impacts on soil microbial communities and associated soil health. While there have been several studies comparing pasture farming to other forms of land use, we still have limited understanding of how the soil microbial communities vary between pasture farms and according to management practices. Here we present the results of a field survey across 56 UK livestock farms that are managed by members of the Pasture fed Livestock Association, using amplicon sequencing of the 16S and ITS regions to characterise the soil bacterial and fungal community within fields that have been under pasture for differing durations. We show that grazing management intensity has only limited effects upon microbial community structure, while the duration of pasture since ploughing (ranging from 1 year to over 100 years) impacted the fungal community structure. The impact of management duration was conditional upon soil physicochemical properties, particularly pH. Plant community effects on upon soil bacterial and fungal composition appear to also interact with the soil chemistry, highlighting the importance of plant-soil interactions in determining microbial community structure. Analyses of microbial indicators revealed proportionally more fungal taxa that responded to multiple ecosystem health associated properties than bacterial taxa. We also identified several fungal taxa that both acted as indicators of soil health related properties within our dataset and showed differentiation between grassland types in a national survey, indicating the generality of some fungal indicators to the national level. Members of the Agaricomycetes were associated with multiple indicators of soil health. Our results show the importance of maintaining grassland for the development of plant-soil interactions and microbial community structure with concomitant effects on soil and general ecosystem health

    Dynamic early identification of hip replacement implants with high revision rates. Study based on the NJR data from UK during 2004-2012

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    BACKGROUND: Hip replacement and hip resurfacing are common surgical procedures with an estimated risk of revision of 4% over 10 year period. Approximately 58% of hip replacements will last 25 years. Some implants have higher revision rates and early identification of poorly performing hip replacement implant brands and cup/head brand combinations is vital. AIMS: Development of a dynamic monitoring method for the revision rates of hip implants. METHODS: Data on the outcomes following the hip replacement surgery between 2004 and 2012 was obtained from the National Joint Register (NJR) in the UK. A novel dynamic algorithm based on the CUmulative SUM (CUSUM) methodology with adjustment for casemix and random frailty for an operating unit was developed and implemented to monitor the revision rates over time. The Benjamini-Hochberg FDR method was used to adjust for multiple testing of numerous hip replacement implant brands and cup/ head combinations at each time point. RESULTS: Three poorly performing cup brands and two cup/ head brand combinations have been detected. Wright Medical UK Ltd Conserve Plus Resurfacing Cup (cup o), DePuy ASR Resurfacing Cup (cup e), and Endo Plus (UK) Limited EP-Fit Plus Polyethylene cup (cup g) showed stable multiple alarms over the period of a year or longer. An addition of a random frailty term did not change the list of underperforming components. The model with added random effect was more conservative, showing less and more delayed alarms. CONCLUSIONS: Our new algorithm is an efficient method for early detection of poorly performing components in hip replacement surgery. It can also be used for similar tasks of dynamic quality monitoring in healthcare

    Fluid gels: a new feedstock for high viscosity jetting

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    Suspensions of gel particles which are pourable or spoonable at room temperature can be created by shearing a gelling biopolymer through its gelation (thermal or ion mediated) rather than allowing quiescent cooling – thus the term ‘fluid gel’ may be used to describe the resulting material. As agar gelation is thermoreversible this type of fluid gel is able to be heated again to melt agar gel particles to varying degrees then re-form a network quiescently upon cooling, whose strength depends on the temperature of re-heating, determining the amount of agar solubilised and subsequently able to partake in re-gelation. Using this principle, for the first time fluid gels have been applied to a high viscosity 3D printing process wherein the printing temperature (at the nozzle) is controllable. This allows the use of ambient temperature feedstocks and by altering the nozzle temperature, the internal nature (presence or absence of gel particles) and gel strength of printed droplets differs. If the nozzle prints at different temperatures for each layer a structure with modulated texture could be created
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