62 research outputs found
Serum thymidine kinase 1 concentration as a predictive biomarker in prostate cancer
Background Thymidine kinase 1 (TK1) recycles DNA before cell division. We do not know if baseline blood concentrations of TK1 predict death in prostate cancer within 30 years. Our objective is to determine if there is an association between baseline levels of TK1 and future prostate cancer-specific mortality. Methods With a "proof of concept" approach, we performed a nested case-control study among 1782 individuals screened for prostate cancer between 1988 and 1989. The concentration of TK1 was measured in frozen serum from 330 men, 36 of whom have died of prostate cancer. The primary endpoint was prostate cancer-specific mortality and outcomes after 30 years were analyzed using logistic regression modeling odds ratios (Ors). Results The estimated OR (adjusted for age) for dying from prostate cancer among the men who had a TK1 value in the upper tertile was 2.39 (95% confidence interval 1.02-5.63). The corresponding OR, regardless of the cause of death, was 2.81 (1.24-6.34). Conclusions High levels of TK1 predicts death in prostate cancer within 30 years of follow-up
A randomised, double-blind, dose-finding, phase II multicentre study of ODX in the treatment of patients with castration-resistant prostate cancer and skeletal metastases
publishedVersionPeer reviewe
Seventeen-year follow-up of the prospective randomized Nordic CIS study: BCG monotherapy versus alternating therapy with mitomycin C and BCG in patients with carcinoma in situ
Ploidy profile of morphologically normal squamous epithelium adjacent to high grade cervical intraepithelial neoplasia
Prognostic Significance of Mucosal Aneuploidy in Stage Ta/T1 Grade 3 Carcinoma of the Bladder
Improving the Performance of a New Storage and Retrieval Machine Based on a Parallel Manipulator Using FMEA Analysis
Erratum: Variation in percentage-free prostate-specific antigen (PSA) with prostate volume, age and total PSA level (British Journal of Urology International 87 (638-642))
IS DIHYDROTESTOSTERON A PROGNOSTIC FACTOR AMONG MEN WITH SCREENING-DETECTED PROSTATE CANCER?
Long-Term Efficacy of Intravesical Bacillus Calmette-Guerin for Carcinoma in Situ: Relationship of Progression to Histological Response and p53 Nuclear Accumulation
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