Penerapan FIS Metode Tsukamoto untuk Menentukan Kelayakan Pemberian Kredit

PT. Interyasa Mitra Mandiri merupakan Perusahaan yang bergerak dibidang pemberian tunai ataupun kedit elektronik dan furniture. Pemberian kredit ditentukan berdasarkan kelayakan pemberian kredit, yaitu dengan menggunakan tenaga survey yang dianggap lebih mengenal karakter personal, wilayah dan keadaan ekonomi calon debitur, dari mulai follow up calon debitur, survey tempat tinggal, lingkungan dan tempat bekerja. Dalam pengambilan keputusan layak atau tidak layak, dilakukan atas dasar petunjuk dari surveyor kepada team analis sehingga analisa kredit oleh surveyor serta pengambilan keputusan oleh team analis setempat kurang cermat. Penelitian ini akan menerapkan FIS metode tsukamoto untuk menentukan kelayakan pemberian kredit, khususnya di PT. Interyasa Mitra Mandiri dengan menggunakan lima variable input, yaitu character, capacity, capital, condition of economy, collateral dan variable output yaitu layak dan tidak layak. Penelitian ini berhasil menerapkan FIS metode tsukamoto untuk membuat sistem pendukung keputusan kelayakan pemberian kredit terhadap calon customer. Sistem yang dibuat dapat membantu Perusahaan dalam mengatur sistem penyimpanan data pengajuan kredit sehingga menjadi leb ih baik dari sebelumnya

Speech Recognation pada Pola Warna Dasar Merah Kuning Hijau dengan Implementasi Sdk 5.1

Sound can not propagate in space vacuum . These sound waves have valleys and hills , valleys and hills of the fruit will result in one cycle or period . This cycle takes place repeatedly , leading to the concept of frequency . Clearly , the frequency is the number of cycles that occur in one second . The unit of frequency is Hertz , abbreviated Hz . Color can provide powerful information for object recognition . A simple real scheme and identification of matching the image based on the color histogram as proposed by Swain and Ballard . From this study, the authors onclude that the Speech SDK 5.1 is less able to recognize intonation delivered with a level of accuracy that is obtained is average success of 75 % + 65 % + 90 % = 230 % , 230 % / 3 = 76.67 %

Estrategias didácticas para la elaboración de módulos de aprendizaje de actividad cognitiva

Resulta innegable, el gran y valioso aporte que la Tecnología Educativa ha brindado a la educación, con el fin de favorecer el proceso de enseñanza aprendizaje, ofreciendo un aporte significativo como los medios didácticos, los módulos de aprendizajes, guías didácticas, vídeos y otros. Por otro lado, es evidente observar la forma vertiginosa como se han dado cambios tecnológicos en nuestra sociedad, motivo por el cual, el docente debe renovar y variar constantemente los métodos y recursos educativos que ha de utilizar en su praxis educativa. Esta tecnología, orienta al docente en la utilización y aprovechamiento de diversos medios tecnológicos que respeten el estudio y la capacidad de aprendizaje de cada uno de sus estudiantes. Debido a que nuestra sociedad demanda el uso adecuado de los recursos, medios y estrategias didácticas y tecnológicas por parte del docente, ante la problemática de orden social que viven muchos de nuestros estudiantes, se ha dado la preocupación de proponer el uso de una guía didáctica para el diseño y elaboración de módulos de aprendizaje de actividad cognitiva. Esta investigación titulada "ESTRATEGIAS DIDÁCTICAS PARA LA ELABORACION DE MODULOS DE APRENDIZAJE DE ACTIVIDAD COGNITIVA," se realiza en el Centro Básica General Ernesto T Lefevre durante el año lectivo del año 2,001 en la provincia de Panamá con una muestra de 54 estudiantes. La metodología utilizada para recoger la información necesaria de los estudiantes, fue la aplicación de una encuesta de diez preguntas para conocer los aspectos más relevantes del estudio, un pre test y pos test. También se encuestan a 30 docentes, de tres Centros de Básica General de la provincia de Panamá, con el fin de recoger la información necesaria, para complementar el trabajo de investigación A través del estudio se ha podido comprobar, que los módulos de aprendizaje de actividad cognitiva, adecuadamente diseñados y elaborados, representan una valiosa herramienta tecnológica, en las manos del docente dispuesto a elevar la calidad de aprendizajes de sus estudiantes

Two patients with history of STEC-HUS, posttransplant recurrence and complement gene mutations

Hemolytic uremic syndrome (HUS) is a disease of microangiopathic hemolytic anemia, thrombocytopenia and acute renal failure. About 90% of cases are secondary to infections by Escherichia coli strains producing Shiga-like toxins (STEC-HUS), while 10% are associated with mutations in genes encoding proteins of complement system (aHUS). We describe two patients with a clinical history of STEC-HUS, who developed end-stage renal disease (ESRD) soon after disease onset. They received a kidney transplant but lost the graft for HUS recurrence, a complication more commonly observed in aHUS. Before planning a second renal transplantation, the two patients underwent genetic screening for aHUS-associated mutations that revealed the presence of a heterozygous CFI mutation in patient #1 and a heterozygous MCP mutation in patient #2, and also in her mother who donated the kidney. This finding argues that the two cases originally diagnosed as STEC-HUS had indeed aHUS triggered by STEC infection on a genetic background of impaired complement regulation. Complement gene sequencing should be performed before kidney transplantation in patients who developed ESRD following STEC-HUS since they may be undiagnosed cases of aHUS, at risk of posttransplant recurrence. Furthermore, genetic analysis of donors is mandatory before living-related transplantation to exclude carriers of HUS-predisposing mutations. Two patients with a clinical history of D+ hemolytic uremic syndrome associated with Shiga-toxin-producing 0157:H7 E. coli and recurrence in the kidney graft carry heterozygous mutations in the genes encoding complement factor I (patient 1) and membrane cofactor protein (patient 2). © Copyright 2013 The American Society of Transplantation and the American Society of Transplant Surgeons

In-Field LAMP Detection of Flavescence Dorée Phytoplasma in Crude Extracts of the Scaphoideus titanus Vector

One of the most destructive diseases affecting grapevine in Europe is caused by Flavescence Dorée phytoplasma (FDp), which belongs to the 16Sr-V group and is a European Union quarantine pathogen. Although many molecular techniques such as loop-mediated isothermal amplification (LAMP) are widely used for the rapid detection of FDp in infected grapevine plants, there is no developed isothermal amplification assay for FDp detection in the insect vectors that are fundamental for the spread of the disease. For this reason, a simple in-field real-time LAMP protocol was optimized and developed for the specific detection of FDp in the insect vector Scaphoideus titanus. The LAMP assay was optimized to work with crude insect extracts obtained by manually shaking a single insect in a buffer for 5 min. Such a simple, sensitive, specific, economic, and user-friendly LAMP assay allowed the detection of FDp in S. titanus in less than half an hour, directly in the field. The developed insect tissue preparation procedure, combined with the LAMP protocol, promptly revealed the presence of FDp in infected S. titanus directly in the vineyards, allowing for monitoring of the spread of the pathogen in the field and to apply timely strategies required for the mandatory control of this pathogen

Clonal Chromosome Anomalies Affecting Fli1 Mimic Inherited Thrombocytopenia Of The Paris-Trousseau Type

Introduction: The thrombocytopenia of the Paris-Trousseau (TCPT) type is a contiguous gene syndrome characterized by mild bleeding tendency, variable thrombocytopenia (THC), abnormal giant alpha-granules in platelets and dysmegakaryopoiesis: it derives from a constitutional deletion of chromosome 11 leading to the loss of FLI1, a transcription factor involved in megakaryocyte differentiation and maturation. Case report: A women with an acquired, isolated THC developing over 10 yr showed morphological features typical of TCPT in platelets and bone marrow (BM). Twenty years after the onset of THC, the other hematological parameters are still normal and the patient is well. Results: Clonal hemopoiesis was shown and chromosome analyses performed on BM revealed a clone with 45 chromosomes and a complex unbalanced translocation involving chromosomes 2, 3, and 11. The anomaly was present in the majority of bone marrow cells but only in a few peripheral blood elements. A microarray-based comparative genomic hybridization defined the deleted region of chromosome 11 including the FLI1 locus that was missing. Conclusion: Although our patient presented with nearly all the characteristics of TCPT, her illness was acquired instead of being inherited and the most appropriate diagnosis is that of the unilineage dysplasia 'refractory THC.' This observation suggests that appropriate cytogenetic investigations should be always considered in patients with acquired THC of unknown origin

Survey of five major grapevine viruses infecting Blatina and Žilavka cultivars in Bosnia and Herzegovina

The sanitary status of grapevines has not yet been considered sufficiently in vineyards throughout Bosnia and Herzegovina (BiH). An extensive survey of five major grapevine viruses in the country was carried out in 2019. A total of 630 samples from the two dominant autochthonous cultivars, namedZ? ilavka and Blatina, were tested by DAS-ELISA for the presence of grapevine leafroll-associated viruses (GLRaV-1 and 3), grapevine fleck virus (GFkV), grapevine fanleaf virus (GFLV) and Arabis mosaic virus (ArMV). Eighty-eight %of the samples were positive for at least one virus, and all five viruses were detected, thought with different incidence, i.e. GLRaV-3 (84%), GFLV (43%), GLRaV-1 (14%), GFkV (10%) and ArMV (0.2%). The majority of infected plants (about 75%) were asymptomatic. Specific virus symptoms were observed in the remaining infected plants, together with the reported GLRaV vectors, Planococcus ficus and Parthenolecanium corni, while nematodes of the Xiphinema genus were not found in the GFLV- or ArMV-infected vineyards. The GLRaV-3 CP phylogenetic analyses showed 75-100% nucleotide identity between the BiH and reference isolates, and the BiH isolates clustered into the major group. The dNS/dS ratio indicated a negative selection of the virus population, and the lack of geographical structuring within the population was observed. In addition, putative GLRaV-3 recombinants with breakpoints in the 5' of the CP gene were detected, while no recombinant strains were identified for the other four viruses. The obtained results indicate a deteriorated sanitary status of the cultivated grapevines, the prevalence and intraspecies genetic diversity of GLRaV-3 throughout the country. The establishment of certified grapevine material and adequate virus vector control is therefore of primary importance to prevent further spread of these viruses. This study presents the results of the first molecular characterisation of grapevine viruses in Bosnia and Herzegovina