What Color Is the Peacekeeper\u27s Helmet?

The term peacekeeping suffer from imprecision, and part of the reason is that the concept derived from the United Nations and state practice, not from express terms in the UN Charter. The advantage of the loose, ordinary sense in which the term is commonly employed by the press and the general public is that it conveys an idea that people believe they understand. It is for that reason that the expression peacekeeping operation is used here to encompass both traditional peacekeeping and enforcement operations

Panel Discussion On International Environmental Crimes: Problems Of Enforceable Norms And Accountability

This panel\u27s scope of discussion covers norms as well as compliance regarding international environmental crimes during both times of peace and armed conflict

Foreword

The editors of the 1984 Law of the Sea Symposium asked that this Foreword concentrate on the future developments of the law of the sea. Implicit in the request is the assumption that the post-1984 period merits an examination of where the law of the sea is headed. the editors\u27 assumption is a valid one. On the final date for signature, December 10, 1984, there were 159 signatures to the United Nations Convention on the Law of the Sea the Convention. This number alone justifies the exploration of what lies ahead in the new era of oceans law, ushered in by the wide acceptance of a comprehensive Convention

What Color Helmet?

Dr. Nordquist\u27s study reviews past peacekeeping operations and the aspects of the Charter of the United Nations that govern the use of force. He proposes that, given the end of the Cold War, distinctions in the UN Charter framework between traditional peacekeeping and enforcement actions can and ought to be reflected in future Security Council peacekeeping mandates.https://digital-commons.usnwc.edu/usnwc-newport-papers/1010/thumbnail.jp

Physical working conditions and subsequent sickness absence : a record linkage follow-up study among 19-39-year-old municipal employees

Purpose Physical work exposures are associated with sickness absence among older employees. We aimed to examine if they similarly contribute to all-cause sickness absence during early and mid-careers. Methods We used questionnaire data on physical work exposures linked to register data on sickness absence from 3542 municipal employees aged 19-39 years. Follow-up for the number of sickness absence days was 12 months. Exposures to physical workload, occupational environmental hazards, and sedentary work were divided into quartiles. In addition, duration of daily exposure to heavy work was included. Negative binomial regression models were used. Results Higher exposure to physical workload or hazardous exposures was associated with a higher number of sickness absence days. The age and gender adjusted rate ratios for sickness absence days among the participants whose exposure to physical workload was in the highest exposure quartile were 2.1 (95% CI 1.8-2.5) compared with those whose exposure was in the lowest quartile. In addition, rate ratios for sickness absence days among participants who reported that they do heavy physical work 1.1-2.0 h, 2.1-4.0 h or over 4 h daily were 1.6 (1.3-1.9), 1.5 (1.3-1.8) and 1.7 (1.5-2.1), respectively, compared with those who reported not doing physical work. Further adjustment for lifestyle factors or health characteristics attenuated the associations only slightly. Conclusion Exposure to physically demanding work is associated with a higher number of sickness absence days among municipal employees below 40 years of age. Physical working conditions should be considered when aiming to support later work ability.Peer reviewe

Synthetic DNA immunotherapy in biochemically relapsed prostate cancer

Background: INO-5150 (PSA and PSMA) +/- INO-9012 (IL-12), a synthetic DNA immunotherapy, was assessed for safety, immunogenicity and efficacy in biochemically recurrent prostate cancer patients (pts). Methods: Phase I, open-label, multi-center study in the US included pts with rising PSA after surgery and/or RT, PSA doubling time (PSADT) \u3e3 months (mos), testosterone \u3e150 ng/dL and no concurrent ADT. Safety, immunogenicity and efficacy (PSA kinetics, PFS) were evaluated in 4 treatment arms of 15 pts each. Arms A: 2mg INO-5150, B: 8.5 mg INO-5150, C: 2mg INO-5150 + 1mg INO-9012 and D: 8.5mg INO-5150 + 1mg INO-9012. Pts received 4 IM doses of vaccine followed by electroporation on day 0, wks 3, 12 and 24 and were followed for 72 wks. Results: 50/61 (82%) pts completed all visits and treatments were well tolerated with no safety concerns. Median PFS for overall population [N = 61, baseline (D0) PSADT range (mos) 1.5-217.1, median 9.8] and for a subset of pts with D0 PSADT ≤12mos (N = 36) has not yet been reached (FU 3-19 mos). 86% of pts with D0 PSADT ≤12 mos were progression free through 19mos FU. 27 out of 36 (75%) pts with D0 PSADT≤ 12 mos had disease stabilization at wks 27 evidenced by significant improvement in log2PSA change over time (slope) and PSADT from D0 (Slope=0.19 declined to 0.1, PSADT=5.3 improved to 10.1 mos, p = \u3c0.0001). This effect was maintained at wk 72 (Slope=0.09, PSADT=10.6, p = \u3c0.0001). Immunogenicity was observed in 77% (47/61) of pts by multiple immunologic assessments. Patient immunogenicity to INO-5150 as determined by CD38 and Perforin + CD8 T cell immune reactivity correlated with attenuated % PSA rise compared to pts without reactivity (p = 0.05, n = 50). Conclusions: INO-5150 +/- INO-9012 was safe, well tolerated and immunogenic. Clinical efficacy was observed in the patients with D0 PSADT≤ 12 mos as evidenced by a significant dampening of log2PSA change over time and increased PSADT up to 72 weeks FU. Additional genomic analyses are ongoing to further elucidate the correlation of immunologic efficacy and clinical benefit. (NCT02514213)

Assessing risk and building resilience to facilitate the transition towards circular food systems

There is potential for circular food systems to improve quality of life for humans, farmed animals, and ecosystems. However, increasing circularity in the food system brings with it novel risks that should be managed to avoid negative unintended consequences. Under circularity, the interconnectivity of food subsystems is likely to increase. For example, waste streams are proposed to be used as feed or fertilizer. Creating such loops brings novel risks that may become reinforcing. Risk is interdependent across system scales and may related to animal welfare, pollution, spread of disease, or international trade. If these risks are not identified, managed, and regulated, the project of transition to circular food systems may be undermined. We propose a new, multidisciplinary framework for managing and governing risk within circular food systems, more specifically within the EU including the context of the Green Deal. Our framework places an emphasis on building resilience of food subsystems as a pathway to managing risk. We explore how the current movement toward restructuring of interconnections within the food system to increase circularity may introduce novel and unintended risk factors, and how this connectivity can be managed to mitigate these risks. We outline how risk owners can be identified and connected to improve governance across food system scales. Finally, we explain how resilience principles can be applied to manage changing risk associated with transition to a circular food system. Relationship of the contribution to SDGs: SDG 2: Zero hunger: target 2.4 and target 2.5 SDG 12: Responsible consumption and production: target 12.8 By 2030 SDG 15: Life on land: target 15.5, target 15.8, target 15.9 Relationship of the contribution to the theme of the Conference – “Sustainable Development and Courage. Culture, Art and Human Rights”. Transition in food systems, including a potential transition to circular agriculture, is a wicked problem that requires input and insight from many different disciplines in order to oversee the possible effects of changes, and to mitigate the inevitable issues that will arise during transition. The consortium involved in our contribution is specifically selected to include academics from (veterinary) health sciences, environmental sciences, and law; we are very open to collaboration with all disciplines