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Integrating the inputs that shape pancreatic islet hormone release.
The pancreatic islet is a complex mini organ composed of a variety of endocrine cells and their support cells, which together tightly control blood glucose homeostasis. Changes in glucose concentration are commonly regarded as the chief signal controlling insulin-secreting beta cells, glucagon-secreting alpha cells and somatostatin-secreting delta cells. However, each of these cell types is highly responsive to a multitude of endocrine, paracrine, nutritional and neural inputs, which collectively shape the final endocrine output of the islet. Here, we review the principal inputs for each islet-cell type and the physiological circumstances in which these signals arise, through the prism of the insights generated by the transcriptomes of each of the major endocrine-cell types. A comprehensive integration of the factors that influence blood glucose homeostasis is essential to successfully improve therapeutic strategies for better diabetes management
Polyhedral vesicles
Polyhedral vesicles with a large bending modulus of the membrane such as the
gel phase lipid membrane were studied using a Brownian dynamics simulation. The
vesicles exhibit various polyhedral morphologies such as tetrahedron and cube
shapes. We clarified two types of line defects on the edges of the polyhedrons:
cracks of both monolayers at the spontaneous curvature of monolayer , and a crack of the inner monolayer at . Around the
latter defect, the inner monolayer curves positively. Our results suggested
that the polyhedral morphology is controlled by .Comment: 4 pages, 5 figure
All-optical transport and compression of ytterbium atoms into the surface of a solid immersion lens
We present an all-optical method to load 174Yb atoms into a single layer of
an optical trap near the surface of a solid immersion lens which improves the
numerical aperture of a microscope system. Atoms are transported to a region 20
um below the surface using a system comprised by three optical dipole traps.
The "optical accordion" technique is used to create a condensate and compress
the atoms to a width of 120 nm and a distance of 1.8 um away from the surface.
Moreover, we are able to verify that after compression the condensate behaves
as a two-dimensional quantum gas.Comment: 5 pages, 5 figure
Numerical approach for retention characteristics of double floating-gate memories
We report on a numerical investigation in which memory characteristics of
double floating-gate (DFG) structure were compared to those of the conventional
single floating-gate structure, including an interference effect between two
cells. We found that the advantage of the DFG structure is its longer retention
time and the disadvantage is its smaller threshold voltage shift. We also
provide an analytical form of charging energy including the interference
effect.Comment: 4 pages, 4 figure
The Nuclear Activity of the Galaxies in the Hickson Compact Groups
In order to investigate the nuclear activity of galaxies residing in compact
groups of galaxies, we present results of our optical spectroscopic program
made at Okayama Astrophysical Observatory. We have performed optical
spectroscopy of 69 galaxies which belong to 31 Hickson Compact Groups (HCGs) of
Galaxies. Among them, three galaxies have discordant redshifts. Further,
spectral quality is too poor to classify other three galaxies. Therefore, we
describe our results for the remaining 63 galaxies.
Our main results are summarized below. (1) We have found in our sample; 28
AGN, 16 HII nuclei, and 19 normal galaxies which show no emission line. We used
this HCG sample for statistical analyses. (2) Comparing the frequency
distributions of activity types between the HCGs and the field galaxies whose
data are taken from Ho, Filippenko, & Sargent (382 field galaxies), we find
that the frequency of HII nuclei in the HCGs is significantly less than that in
the field. However, this difference may be due to selection bias that our HCG
sample contains more early-type galaxies than the field, because it is known
that HII nuclei are rarer in early-type galaxies than in later ones. (3)
Applying correction this morphological bias to the HCG sample, we find that
there is no statistically significant difference in the frequency of occurrence
of emission-line galaxies between the HCGs and the field. This implies that the
dense galaxy environment in the HCGs does not affect triggering both the AGN
activity and the nuclear starburst. We discuss some implications on the nuclear
activity in the HCG galaxies.Comment: 33 pages (3 aasms4 LaTeX files), 5 figures (5 Postscript files:
excluded Figure 1), Accepted for publication in The Astronomical Journa
Dissociating task difficulty from incongruence in face-voice emotion integration
In the everyday environment, affective information is conveyed by both the face and the voice. Studies have demonstrated that a concurrently presented voice can alter the way that an emotional face expression is perceived, and vice versa, leading to emotional conflict if the information in the two modalities is mismatched. Additionally, evidence suggests that incongruence of emotional valence activates cerebral networks involved in conflict monitoring and resolution. However, it is currently unclear whether this is due to task difficulty—that incongruent stimuli are harder to categorize—or simply to the detection of mismatching information in the two modalities. The aim of the present fMRI study was to examine the neurophysiological correlates of processing incongruent emotional information, independent of task difficulty. Subjects were scanned while judging the emotion of face-voice affective stimuli. Both the face and voice were parametrically morphed between anger and happiness and then paired in all audiovisual combinations, resulting in stimuli each defined by two separate values: the degree of incongruence between the face and voice, and the degree of clarity of the combined face-voice information. Due to the specific morphing procedure utilized, we hypothesized that the clarity value, rather than incongruence value, would better reflect task difficulty. Behavioral data revealed that participants integrated face and voice affective information, and that the clarity, as opposed to incongruence value correlated with categorization difficulty. Cerebrally, incongruence was more associated with activity in the superior temporal region, which emerged after task difficulty had been accounted for. Overall, our results suggest that activation in the superior temporal region in response to incongruent information cannot be explained simply by task difficulty, and may rather be due to detection of mismatching information between the two modalities
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