30 research outputs found
Optical orthogonal codes obtained from conics on finite projective planes
AbstractOptical orthogonal codes can be applied to fiber optical code division multiple access (CDMA) communications. In this paper, we show that optical orthogonal codes with auto- and cross-correlations at most 2 can be obtained from conics on a finite projective plane. In addition, the obtained codes asymptotically attain the upper bound on the number of codewords when the order q of the base field is large enough
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Effect of CPT-11 in combination with other anticancer agents in lung cancer cells
To determine the optimal combination of commonly used anticancer agents with 7-ethyl-10-hydroxy-camptothecin (SN-38), an active metabolite of 7-ethyl-10-[4(1-piperidino)- 1-piperidino] carbonyloxy camptothecin (CPT-11), for chemotherapy of lung cancer, we studied the effects of SN- 38 In combination with six representative anticancer agents on the human small cell lung cancer (SCLC) cell line, NCI N417, and the non-small cell lung cancer (NSCLC) cell line, PC-9. The anticancer activity was evaluated by MTT assay and the effects of drug combinations on ID50 were analyzed by an improved isobologram method. In the SCLC cell line, supra-additive effect was observed for SN-38 in combination with cisplatin, etoposide (VP-16) and paclitaxel (Taxol). An additive effect was observed for its combination with bleomycin. Sub-additive and protective effects were found in combination with adrlamycin (ADR) and 5-fluorouracil (5- FU). In the NSCLC cell line, supra-additive and marginal supra-additive effects were found for SN-38 in combination with VP-16, ADR, 5-FU and bleomycin. The others showed additive effects with SN-38. No drug showed sub-additive and protective effects with SN-38. These results suggest that all the drugs we selected can be used with SN-38 simultaneously for NSCLC, while for SCLC, cisplatin, VP-16 and Taxol are the most suitable for combination with SN-38