Coincidence analysis to search for inspiraling compact binaries using TAMA300 and LISM data

Japanese laser interferometric gravitational wave detectors, TAMA300 and LISM, performed a coincident observation during 2001. We perform a coincidence analysis to search for inspiraling compact binaries. The length of data used for the coincidence analysis is 275 hours when both TAMA300 and LISM detectors are operated simultaneously. TAMA300 and LISM data are analyzed by matched filtering, and candidates for gravitational wave events are obtained. If there is a true gravitational wave signal, it should appear in both data of detectors with consistent waveforms characterized by masses of stars, amplitude of the signal, the coalescence time and so on. We introduce a set of coincidence conditions of the parameters, and search for coincident events. This procedure reduces the number of fake events considerably, by a factor $\sim 10^{-4}$ compared with the number of fake events in single detector analysis. We find that the number of events after imposing the coincidence conditions is consistent with the number of accidental coincidences produced purely by noise. We thus find no evidence of gravitational wave signals. We obtain an upper limit of 0.046 /hours (CL $= 90$) to the Galactic event rate within 1kpc from the Earth. The method used in this paper can be applied straightforwardly to the case of coincidence observations with more than two detectors with arbitrary arm directions.Comment: 28 pages, 17 figures, Replaced with the version to be published in Physical Review

Results of the search for inspiraling compact star binaries from TAMA300's observation in 2000-2004

We analyze the data of TAMA300 detector to search for gravitational waves from inspiraling compact star binaries with masses of the component stars in the range 1-3Msolar. In this analysis, 2705 hours of data, taken during the years 2000-2004, are used for the event search. We combine the results of different observation runs, and obtained a single upper limit on the rate of the coalescence of compact binaries in our Galaxy of 20 per year at a 90% confidence level. In this upper limit, the effect of various systematic errors such like the uncertainty of the background estimation and the calibration of the detector's sensitivity are included.Comment: 8 pages, 4 Postscript figures, uses revtex4.sty The author list was correcte

Postazacitidine clone size predicts long-term outcome of patients with myelodysplastic syndromes and related myeloid neoplasms

Azacitidine is a mainstay of therapy for MDS-related diseases. The purpose of our study is to elucidate the effect of gene mutations on hematological response and overall survival (OS), particularly focusing on their post-treatment clone size. We enrolled a total of 449 patients with MDS or related myeloid neoplasms. They were analyzed for gene mutations in pre- (n=449) and post- (n=289) treatment bone marrow samples using targeted-capture sequencing to assess the impact of gene mutations and their post-treatment clone size on treatment outcomes. In Cox proportional hazard modeling, multi-hit TP53 mutation (HR, 2.03; 95% CI, 1.42-2.91; P<.001), EZH2 mutation (HR, 1.71; 95% CI, 1.14-2.54; P=.009), and DDX41 mutations (HR, 0.33; 95% CI, 0.17-0.62; P<.001), together with age, high-risk karyotypes, low platelet, and high blast counts, independently predicted OS. Post-treatment clone size accounting for all drivers significantly correlated with International Working Group (IWG)-response (P<.001, trend test), except for that of DDX41-mutated clones, which did not predict IWG-response. Combined, IWG-response and post-treatment clone size further improved the prediction of the original model and even that of a recently proposed molecular prediction model, IPSS-M (c-index, 0.653 vs 0.688; P<.001, likelihood ratio test). In conclusion, evaluation of post-treatment clone size, together with pre-treatment mutational profile as well as IWG-response have a role in better prognostication of azacitidine-treated myelodysplasia patients

Observation results by the TAMA300 detector on gravitational wave bursts from stellar-core collapses

We present data-analysis schemes and results of observations with the TAMA300 gravitational-wave detector, targeting burst signals from stellar-core collapse events. In analyses for burst gravitational waves, the detection and fake-reduction schemes are different from well-investigated ones for a chirp-wave analysis, because precise waveform templates are not available. We used an excess-power filter for the extraction of gravitational-wave candidates, and developed two methods for the reduction of fake events caused by non-stationary noises of the detector. These analysis schemes were applied to real data from the TAMA300 interferometric gravitational wave detector. As a result, fake events were reduced by a factor of about 1000 in the best cases. The resultant event candidates were interpreted from an astronomical viewpoint. We set an upper limit of 2.2x10^3 events/sec on the burst gravitational-wave event rate in our Galaxy with a confidence level of 90%. This work sets a milestone and prospects on the search for burst gravitational waves, by establishing an analysis scheme for the observation data from an interferometric gravitational wave detector

Mesodiverticular bandによる絞扼性イレウスの一例

症例は14歳,男児.開腹歴を含め,既往歴に特記すべきものなし.下痢,腹痛を主訴に来院し,抗生剤投与で一時軽快したが,その後腹部膨満感出現し,緊急入院となった.入院時血液検査所見で炎症反応の異常高値とCT検査上絞拒性イレウスの所見を認めたため緊急開腹手術を施行した.術中所見は回腸から約60cm口側にメッケル憩室を認め,そこに付着したmesodiverticular bandにより回腸が内ヘルニアを形成していた.小腸は広範囲に壊死しており,小腸部分切除を行った.mesodiverticular bandによるイレウスは稀で,術前診断は困難であるため手術歴のないイレウスの原因として考慮すべきであると考えられた.The patient was a 14-year-old boy who was admitted to our hospital because of abdominal pain and diarrhea. Blood tests showed strong inflammation, and plain CT showed the presence of air and fluid in the ileum. In physical findings, pan-peritonitis was suspected with muscle guarding, and so on emergency operation was performed. During the operation, we found that the ileum was compressed by a herniation of the mesodiverticular band and Meckel\u27s diverticulum. The a long segment of the ileum was necrotic, so these portions were resected and an end to side anastomosis was made. In a pathological study, neither gastric mucosa nor pancreatic tissue were observed, but microvessels were seen. Diagnosis is difficult before operation, so we should consider the mesodiverticular band when we see young ileus cases

Model-Free Deep Recurrent Q-Network Reinforcement Learning for Quantum Circuit Architectures Design

Artificial intelligence (AI) technology leads to new insights into the manipulation of quantum systems in the Noisy Intermediate-Scale Quantum (NISQ) era. Classical agent-based artificial intelligence algorithms provide a framework for the design or control of quantum systems. Traditional reinforcement learning methods are designed for the Markov Decision Process (MDP) and, hence, have difficulty in dealing with partially observable or quantum observable decision processes. Due to the difficulty of building or inferring a model of a specified quantum system, a model-free-based control approach is more practical and feasible than its counterpart of a model-based approach. In this work, we apply a model-free deep recurrent Q-network (DRQN) reinforcement learning method for qubit-based quantum circuit architecture design problems. This paper is the first attempt to solve the quantum circuit design problem from the recurrent reinforcement learning algorithm, while using discrete policy. Simulation results suggest that our long short-term memory (LSTM)-based DRQN method is able to learn quantum circuits for entangled Bell–Greenberger–Horne–Zeilinger (Bell–GHZ) states. However, since we also observe unstable learning curves in experiments, suggesting that the DRQN could be a promising method for AI-based quantum circuit design application, more investigation on the stability issue would be required