Bir Olgu Dolayısıyla İnfantisit ve Filisit’in Psikiyatrik Yönü

Kişinin kendi çocuğunu öldürme davranışı, motivasyonları açısından heterojen bir fenomendir. Özellikle annelerin çocuklarını öldürmeleri önceleri tümüyle psikotik bir davranış olarak yorumlanmış olsa bile, günümüzde böyle bir eylemi psikotik olmayan başka motivasyonlarla da yapabilecekleri belirtilmektedir. Psikotik annelerin çocuklarını öldürmeleri çoğu zaman acımak dolayısıyla öldürmek (“mercy killing”) tarzında olmaktadır. Oysa impulsif psikotik bir davranışla ve acıma içermeyen çocuk öldürmelerine de rastlanmaktadır. Bu yazıda son kez beş günlük çocuğunu ve 8 yıl öncesinde de 9 yaşındaki bir başka çocuğunu öldürmüş olan psikotik özellikli depresyon olgusu bir anne incelenmiştir. Bu olgu infantisit ve filisitin motivasyonu bakımından çok seyrek görülen impulsif psikotik bir davranış olarak ortaya çıkmış olması ve tekrarlayıcı niteliği nedeniyle literatürdeki fi- lisitler ve infantisitler bağlamında tartışılmıştır. Anahtar Kelimeler: Filisit, infantisit, motivasyon

A study on the prevalence of metabolic syndrome and the relation with polymorphism of a leptin receptor gene GIn223Arg in schizophrenia inpatients with and without treatment resistance

Objective: This study aimed to determine the prevalence of metabolic syndrome(MetS) and the relation with polymorphism of a leptin receptor gene(LEPR) GIn223Arg in schizophrenia inpatients with and without treatment resistance

Metabolic syndrome and related factors treated with antipsychotics monotherapy and polypharmacy in patients with schizophrenia

Objective: The aim of our study was-to determine the prevalence of MetS and to investigate related factors-in the group of inpatients with schizophrenia treated with antipsychotics monotherapy (AM) and polypharmacy (AP)

Clinical and molecular evaluation of MEFV gene variants in the Turkish population: a study by the National Genetics Consortium

Familial Mediterranean fever (FMF) is a monogenic autoinflammatory disorder with recurrent fever, abdominal pain, serositis, articular manifestations, erysipelas-like erythema, and renal complications as its main features. Caused by the mutations in the MEditerranean FeVer (MEFV) gene, it mainly affects people of Mediterranean descent with a higher incidence in the Turkish, Jewish, Arabic, and Armenian populations. As our understanding of FMF improves, it becomes clearer that we are facing with a more complex picture of FMF with respect to its pathogenesis, penetrance, variant type (gain-of-function vs. loss-of-function), and inheritance. In this study, MEFV gene analysis results and clinical findings of 27,504 patients from 35 universities and institutions in Turkey and Northern Cyprus are combined in an effort to provide a better insight into the genotype-phenotype correlation and how a specific variant contributes to certain clinical findings in FMF patients. Our results may help better understand this complex disease and how the genotype may sometimes contribute to phenotype. Unlike many studies in the literature, our study investigated a broader symptomatic spectrum and the relationship between the genotype and phenotype data. In this sense, we aimed to guide all clinicians and academicians who work in this field to better establish a comprehensive data set for the patients. One of the biggest messages of our study is that lack of uniformity in some clinical and demographic data of participants may become an obstacle in approaching FMF patients and understanding this complex disease