Bis(3,4-dimethoxy­benzoato-κ2 O,O′)(1,10-phenanthroline-κ2 N,N′)copper(II)

The asymmetric unit of the title compound, [Cu(C9H9O4)2(C12H8N2)], contains one half-mol­ecule, the complete mol­ecule being generated by a twofold rotation axis. The CuII atom exhibits a six-coordinated distorted octa­hedral geometry with two N atoms from the phenanthroline ligand [Cu—N 2.007 (2) Å] and four O atoms from two 3,4-dimethoxy­benzoate ligands [Cu—O 1.950 (1) and 2.524 (1) Å]. The difference in Cu—O bond distances indicates a strong Jahn–Teller effect. In the crystal, C—H⋯π inter­actions result in chains of mol­ecules along the c axis

Ruscogenin alleviates palmitic acid-induced endothelial cell inflammation by suppressing TXNIP/NLRP3 pathway

Purpose: To investigate the involvement of ruscogenin in palmitic acid (PA)-induced endothelial cell inflammation. Method: Cultured human umbilical vein endothelial cells (HUVECs) were divided into five groups: control (normal untreated cells), PA (cell treated with palmitic acid), and PA + ruscogenin (1, 10, or 30 μM). Cell viability and apoptosis rate were determined using MTT (3-(4,5)-dimethylthiahiazo(-z-y1)-3,5- di-phenytetrazolium bromide) and flow cytometry assays, respectively. The levels of cytokines, including interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α), intercellular adhesion molecule-1 (ICAM-1), and monocyte chemo-attractant protein-1 (MCP-1) were determined by an enzyme-linked immunosorbent assay. Western blotting and real-time polymerase chain reaction (RT-PCR) were used to evaluate the underlying mechanisms of action. Results: PA treatment decreased the viability of HUVECs and induced apoptosis (p < 0.05). Ruscogenin attenuated PA-induced cell death in a dose-dependent manner (p < 0.05). On the other hand, PA induced an increase in IL-1β, TNF-α, ICAM-1, MCP-1, TXNIP (thioredoxin-interacting protein),as well as NLRP3 (nucleotide oligomerization domain-, leucine-rich repeat- and pyrin domain-containing protein 3), all of which were attenuated by ruscogenin (p < 0.05). Conclusion: Ruscogenin alleviates PA-induced endothelial cell inflammation via TXNIP/NLRP3 pathway, thereby providing an insight into new therapeutic strategies to treat cardiovascular diseases. Keywords: Ruscogenin, Palmitic acid, Endothelial cells, Inflammation, TXNIP, NLRP3, Cardiovascular disease

A novel TODIM based on prospect theory to select green supplier with q-rung orthopair fuzzy set

The authors would like to acknowledge the financial support by the Fundamental Research Funds for the Central Universities (#JBK2001043, and #JBK190969), the FEDER funds provided in the National Spanish project PID2019-103880RB-I00 and also it has been partially supported by grant from the National Natural Science Foundation of China (#71910107002).Green supply chain has developed rapidly due to the advocacy of ecological civilization, and choosing a proper green supplier is a crucial issue. Considering the fuzziness of evaluation information and the psychological states of decision makers (DMs) in selecting process, a novel TODIM based on prospect theory with q-rung orthopair fuzzy set (q-ROFS) is proposed. The novel TODIM concerns both the perceived transformed probability weighting function and the differences in risk attitudes. A new distance, which concerns the herd mentality, is carried out to measure the perceived difference of the q-ROFS. Besides, a new systematic evaluation index system, named as PCEM (Product, Cooperation ability, Environment, Market), has been established. A case related to pork supplier companies is presented and fully demonstrates the effectiveness of the novel TODIM when compared with the extended one, the intuitionistic fuzzy TODIM, the Pythagorean fuzzy TODIM as well as the TOPSIS with q-ROFS. Finally, a series of comparative analyses illustrate the advantages of the proposed TODIM.Fundamental Research Funds for the Central Universities JBK2001043 JBK190969FEDER funds provided in the National Spanish project PID2019-103880RB-I00National Natural Science Foundation of China (NSFC) 7191010700

Interactive Effects of Water and Fertilizer on Yield, Soil Water and Nitrate Dynamics of Young Apple Tree in Semiarid Region of Northwest China

Exploring the interactive effect of water and fertilizer on yield, soil water and nitrate dynamics of young apple tree is of great importance to improve the management of irrigation and fertilization in the apple-growing region of semiarid northwest China. A two-year pot experiment was conducted in a mobile rainproof shelter of the water-saving irrigation experimental station in Northwest A&F University, and the investigation evaluated the response of soil water and fertilizer migration, crop water productivity (CWP), irrigation water use efficiency (IWUE), partial factor productivity (PFP) of young apple tree to different water and fertilizer regimes (four levels of soil water: 75%–85%, 65%–75%, 55%–65% and 45%–55% of field capacity, designated W1, W2, W3 and W4, respectively; three levels of N-P2O5-K2O fertilizer, 30-30-10, 20-20-10 and 10-10-10 g plant−1, designated F1, F2 and F3, respectively). Results showed that F1W1, F2W1 and F3W1 had the highest average soil water content at 0~90 cm compared with the other treatments. When fertilizer level was fixed, the average soil water content was gradually increased with increasing irrigation amount. For W1, W2, W3 and W4, high levels of water content were mainly distributed at 50~80 cm, 40~70 cm, 30~50 cm and 10~30 cm, respectively. There was no significant difference in soil water content at all fertilizer treatments. However, F1 and F2 significantly increased soil nitrate-N content by 146.3%~246.4% and 75.3%~151.5% compared with F3. The highest yield appeared at F1W1 treatment, but there was little difference between F1W1 and F2W2 treatment. F2W2treatment decreased yield by 7.5%, but increased IWUE by 11.2% compared with F1W1 treatment. Meanwhile, the highest CWP appeared at F2W2 treatment in the two years. Thus, F2W2 treatment (soil moisture was controlled in 65–75% of field capacity, N-P2O5-K2O were controlled at 20-20-10 g·tree−1) reached the best water and fertilizer coupling mode and it was the optimum combinations of water and fertilizer saving

ConKI: Contrastive Knowledge Injection for Multimodal Sentiment Analysis

Multimodal Sentiment Analysis leverages multimodal signals to detect the sentiment of a speaker. Previous approaches concentrate on performing multimodal fusion and representation learning based on general knowledge obtained from pretrained models, which neglects the effect of domain-specific knowledge. In this paper, we propose Contrastive Knowledge Injection (ConKI) for multimodal sentiment analysis, where specific-knowledge representations for each modality can be learned together with general knowledge representations via knowledge injection based on an adapter architecture. In addition, ConKI uses a hierarchical contrastive learning procedure performed between knowledge types within every single modality, across modalities within each sample, and across samples to facilitate the effective learning of the proposed representations, hence improving multimodal sentiment predictions. The experiments on three popular multimodal sentiment analysis benchmarks show that ConKI outperforms all prior methods on a variety of performance metrics.Comment: Accepted by ACL Findings 202

IL-10 plays a central regulatory role in the cytokines induced by hepatitis C virus core protein and polyinosinic acid:polycytodylic acid

Hepatitis C virus (HCV) can cause persistent infection and chronic liver disease, and viral factors are involved in HCV persistence. HCV core protein, a highly conserved viral protein, not only elicits an immunoresponse, but it also regulates it. In addition, HCV core protein interacts with toll-like receptors (TLRs) on monocytes, inducing them to produce cytokines. Polyinosinic acid:polycytodylic acid (polyI:C) is a synthetic analogue of double-stranded RNA that binds to TLR3 and can induce secretion of type I IFN from monocytes. Cytokine response against HCV is likely to affect the natural course of infection as well as HCV persistence. However, possible effects of cytokines induced by HCV core protein and polyI:C remain to be investigated. In this study, we isolated CD14+ monocytes from healthy donors, cultured them in the presence of HCV core protein and/or polyI:C, and characterized the induced cytokines, phenotypes and mechanisms. We demonstrated that HCV core protein- and polyI:C-stimulated CD14+ monocytes secreted tumor necrosis factor-α (TNF-α), interleukin (IL)-1β, IL-10, and type I interferon (IFN). Importantly, TNF-α and IL-1β regulated the secretion of IL-10, which then influenced the expression of signal transducer and activator of transcription 1 (STAT1) and interferon regulatory factor 1 (IRF1) and subsequently the production of type I IFN. Interestingly, type I IFN also regulated the production of IL-10, which in turn inhibited the nuclear factor (NF)-κB subunit, reducing TNF-α and IL-1β levels. Therefore, IL-10 appears to play a central role in regulating the production of cytokines induced by HCV core protein and polyI:C

ArsR Family Regulator MSMEG_6762 Mediates the Programmed Cell Death by Regulating the Expression of HNH Nuclease in Mycobacteria

Programmed cell death (PCD) is the result of an intracellular program and is accomplished by a regulated process in both prokaryotic and eukaryotic organisms. Here, we report a programed cell death process in Mycobacterium smegmatis, an Actinobacteria species which involves a transcription factor and a DNase of the HNH family. We found that over-expression of an ArsR family member of the transcription factor, MSMEG_6762, leads to cell death. Transcriptome analysis revealed an increase in the genes’ transcripts involved in DNA repair and homologous recombination, and in three members of HNH family DNases. Knockout of one of the DNase genes, MSMEG_1275, alleviated cell death and its over-expression of programmed cell death. Purified MSMEG_1275 cleaved the M. smegmatis DNA at multiple sites. Overall, our results indicate that the MSMEG_6762 affects cell death and is mediated, at least partially, by activation of the HNH nuclease expression under a stress condition

Transcranial Direct Current Stimulation of the Right Lateral Prefrontal Cortex Changes a priori Normative Beliefs in Voluntary Cooperation

A priori normative beliefs, the precondition of social norm compliance that reflects culture and values, are considered unique to human social behavior. Previous studies related to the ultimatum game revealed that right lateral prefrontal cortex (rLPFC) has no stimulation effects on normative beliefs. However, no research has focused on the effects of a priori belief on the rLPFC in voluntary cooperation attached to the public good (PG) game. In this study, we used a linear asymmetric PG to confirm the influence of the rLPFC on a priori normative beliefs without threats of external punishment through transcranial direct current stimulation (tDCS). Participants engaged via computer terminals in groups of four (i.e., two high-endowment players with 35G$and two low-endowment players with 23G$). They were anonymous and had no communication during the entire process. They were randomly assigned to receive 15 min of either anodal, cathodal, or sham stimulation and then asked to answer questions concerning a priori normative beliefs (norm.belief and pg.belief). Results suggested that anodal/cathodal tDCS significantly (P < 0.001) shifted the participants’ a priori normative beliefs in opposite directions compared to the shift in the sham group. In addition, different identities exhibited varying degrees of change (28.80–54.43%). These outcomes provide neural evidence of the rLPFC mechanism’s effect on the normative beliefs in voluntary cooperation based on the PG framework