Linear Fresnel Collector Receiver: Heat Loss and Temperatures

For design and component specification of a Linear Fresnel Collector (LFC) cavity receiver, the prediction of temperature distribution and heat loss is of great importance. In this paper we present a sensitivity analysis for a range of geometry and material parameters. For the LFC receiver analysis we use two models developed at Fraunhofer ISE. One is a detailed model, combining the spatial distribution of reflected radiation via ray tracing with detailed convective simulations through computational fluid dynamics. The second one is a fast algorithm based on a thermal resistance model. It is applying a similar methodology as the well-known model for vacuum absorber, enhancing an absorber tube model by parameters describing the influence of the secondary mirror and cover glass. The thermal resistance model is described in detail. Obtained results indicate a significant effect of the secondary mirror temperature on heat loss for specific geometries

Extended Heat Loss and Temperature Analysis of Three Linear Fresnel Receiver Designs

Heat loss prediction models for parabolic trough receivers do not consider the thermal effect of a secondary mirror. As an extension a Thermal Resistance Model (TRM) has been developed at Fraunhofer ISE for the prediction of the heat loss of three different Linear Fresnel Collector (LFC) receiver configurations. In previous investigations we have found the energy balance of a LFC receiver to be strongly influenced by the amount of solar radiation absorbed by the secondary mirror. This absorption provokes an increase of temperature of the secondary mirror and hence a decrease in the total amount of heat loss of a LFC. The size of this effect depends on the receiver geometry and diverse ambient parameters. Investigated parameters are wind velocity, ambient temperature and Direct Normal Irradiance (DNI). This dependency and its effect on heat loss and secondary mirror temperatures are analyzed for three different LFC receiver configurations. As the radiation absorbed by the secondary mirror is affected by the aperture area of the LFC, studies are performed for small-scale and for large-scale collectors

Cell-type-specific signaling networks in heterocellular organoids

Despite the widespread adoption of organoids as biomimetic tissue models, methods to comprehensively analyze cell-type-specific post-translational modification (PTM) signaling networks in organoids are absent. Here, we report multivariate single-cell analysis of such networks in organoids and organoid cocultures. Simultaneous analysis by mass cytometry of 28 PTMs in >1 million single cells derived from small intestinal organoids reveals cell-type- and cell-state-specific signaling networks in stem, Paneth, enteroendocrine, tuft and goblet cells, as well as enterocytes. Integrating single-cell PTM analysis with thiol-reactive organoid barcoding in situ (TOBis) enables high-throughput comparison of signaling networks between organoid cultures. Cell-type-specific PTM analysis of colorectal cancer organoid cocultures reveals that shApc, KrasG12D and Trp53R172H cell-autonomously mimic signaling states normally induced by stromal fibroblasts and macrophages. These results demonstrate how standard mass cytometry workflows can be modified to perform high-throughput multivariate cell-type-specific signaling analysis of healthy and cancerous organoids

A protocol for an individualised, facilitated and sustainable approach to implementing current evidence in preventing falls in residential aged care facilities

Background. Falls are common adverse events in residential care facilities. Commonly reported figures indicate that at least 50% of residents fall in a 12 month period, and that this figure is substantially higher for residents with dementia. This paper reports the protocol of a project which aims to implement evidence based falls prevention strategies in nine residential aged care facilities (RACFs) in Australia. The facilities in the study include high and low care, small and large facilities, metropolitan and regional, facilities with a specific cultural focus, and target groups recognised as being more challenging to successful implementation of falls prevention practice (e.g. residents with dementia). Methods. The project will be conducted from November 2007-November 2009. The project will involve baseline scoping of existing falls rates and falls prevention activities in each facility, an action research process, interactive falls prevention training, individual falls risk assessments, provision of equipment and modifications, organisation based steering committees, and an economic evaluation. In each RACF, staff will be invited to join an action research group that will lead the process of developing and implementing interventions designed to facilitate an evidence based approach to falls management in their facility. In all RACFs a pre/post design will be adopted with a range of standardised measures utilised to determine the impact of the interventions. Discussion. The care gap in residential aged care that will be addressed through this project relates to the challenges in implementing best practice falls prevention actions despite the availability of best practice guidelines. There are numerous factors that may limit the uptake of best practice falls prevention guidelines in residential aged care facilities. A multi-factorial individualised (to the specific requirements of each facility) approach will be used to develop and implement an action plan in each participating facility based on the best available evidence

Multiplexed single-cell analysis of organoid signaling networks

Organoids are biomimetic tissue models comprising multiple cell types and cell states. Post-translational modification (PTM) signaling networks control cellular phenotypes and are frequently dysregulated in diseases such as cancer. Although signaling networks vary across cell types, there are limited techniques to study cell type–specific PTMs in heterocellular organoids. Here, we present a multiplexed mass cytometry (MC) protocol for single-cell analysis of PTM signaling and cell states in organoids and organoids co-cultured with fibroblasts and leukocytes. We describe how thiol-reactive organoid barcoding in situ (TOBis) enables 35-plex and 126-plex single-cell comparison of organoid cultures and provide a cytometry by time of flight (CyTOF) signaling analysis pipeline (CyGNAL) for computing cell type–specific PTM signaling networks. The TOBis MC protocol takes ~3 d from organoid fixation to data acquisition and can generate single-cell data for >40 antibodies from millions of cells across 126 organoid cultures in a single MC run

A search for anomalously heavy isotopes of low Z nuclei

We present preliminary results of a search for anomalously heavy isotopes of certain light elements using an electrostatic charged particle spectrometer in conjunction with the MP tandem accelerator facility at the Nuclear Structure Research Laboratory of the University of Rochester. New limits for the existence of anomalous, heavy isotopes (100–10,000 amu) in ordinary, terrestrial Li, Be, B and F samples and enriched H2, C13, and O18 samples are reported.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/87394/2/1143_1.pd

Spectral line shape of resonant four-wave mixing induced by broad-bandwidth lasers

We present a theoretical and experimental study of the line shape of resonant four-wave mixing induced by broad-bandwidth laser radiation that revises the theory of Meacher, Smith, Ewart, and Cooper (MSEC) [Phys. Rev. A 46, 2718 (1992)]. We adopt the same method as MSEC but correct for an invalid integral used to average over the distribution of atomic velocities. The revised theory predicts a Voigt line shape composed of a homogeneous, Lorentzian component, defined by the collisional rate Γ, and an inhomogeneous, Doppler component, which is a squared Gaussian. The width of the inhomogeneous component is reduced by a factor of √2 compared to the simple Doppler width predicted by MSEC. In the limit of dominant Doppler broadening, the width of the homogeneous component is predicted to be 4Γ, whereas in the limit of dominant homogeneous broadening, the predicted width is 2Γ. An experimental measurement is reported of the line shape of the four-wave-mixing signal using a broad-bandwidth, "modeless", laser resonant with the Q1 (6) line of the A2 Σ - X2 Π(0,0) system of the hydroxyl radical. The measured widths of the Voigt components were found to be consistent with the predictions of the revised theory