A study of morbidity pattern in Misgav Ladach technique of caesearean section

Background: There has been progressive increase in C-section (CS) rate globally since last 10 years. Issues related to maternal choice, Mode of delivery for non-cephalic presentation at term, vaginal delivery after previous scar have been the focus of attention. The objective of the study was to determine whether Misgav Ladach caesarean section technique offers benefits over Traditional Method of caesarean section with regards to Duration of surgery, Time taken for abdominal entry, Total operation time, Amount of blood loss and Postoperative morbidity.Methods: A randomized control study was carried out on 460 patients who underwent Caesarean section at Krishna hospital, Karad, Maharashtra, India between November 2013 to June 2015.Results: 460 cases of caesarean section admitted to Krishna institute of medical sciences, karad during the period of November 2013 to June 2015 were studied with respect of clinical pattern, majority of the cases who underwent, caesarean section by both the methods were in the age group of 21-25 years. The main indication for caesarean section was fetal distress. Fetal distress accounts for 29% in Misgav Ladach method and 31% in traditional method, failed induction accounts for 6% in Misgav Ladach and 8% in traditional method. The total operation time was 31 min average in Misgav Ladach and 37 min in traditional group. The mean blood loss for the Misgav Ladach group was 486 ml and 521 ml for the traditional group, which was significantly different (p<0.001). The postoperative morbidity due to fever was 4% in the both groups.Conclusions: Substantial reductions in operating time and blood loss were noted in the study, which may benefit the women in reducing the exposure time to anesthesia

Comparative study of sonosalpingography versus hysterosalpingography for tubal patency test

Background: Various tubal pathologies accounts for 10% aetiological factors in infertility couples. Easy availability and accessibility of ultrasonography definitely can prove superior to conventional method of diagnosis of tubal patency in such patient. Aims and objectives of the study were to test the sensitivity and specificity of sonosalpingography (SSG) for tubal patency test in cases of infertility patients attending to our OPD and to compare the result of sonosalpingography v/s HSG.Methods: In a non randomised prospective control trial of 50 women complaining of infertility, suspected tubal pathologies underwent various radiological modalities. Sonosalpingography and hysterosalpingography was performed in all cases.Results: By using binomial proportion test there is no significant difference between results of SSG compare to HSG. Acceptability was 100% in SSG compared to 96% in HSG.Conclusions: Various modalities are suggested to evaluate tubal patency test in infertile women. Among those laparoscopic chromopertubation is gold standard method, but for initial workup as cost effectiveness acceptability, accessibility is concerned SSG is always superior to HSG

PROTECTIVE EFFECT OF NEBIVOLOL ON ALUMINIUM-INDUCED NEUROBEHAVIORAL AND BIOCHEMICAL ALTERATIONS IN RATS

Objective: The present study was designed to investigate the neuroprotective potential of nebivolol, a β1 adrenergic blocker on aluminium-induced neurobehavioral and biochemical alterations in rats. Methods: The neurotoxicity was induced by administration of aluminium (50 mg/kg/day, p.o.) for 5 weeks. Nebivolol was administered at a dose of 10 mg/kg, p.o. for 5 weeks. Behavioral assessments were done by using open field test and modified elevated plus maze (mEPM) test. At the end of the study, oxidative stress parameters were determined and histopathological studies of cerebral cortex of rat brains were performed. Results: Aluminium chloride treated rats showed significant reduction in motor activity in open field test and memory impairment in mEPM test as compared to control group. Nebivolol significantly reversed these parameters and restored brain antioxidant defensive enzymes with reduction in lipid peroxidation. The neurotoxicity was confirmed by the histopathological analysis of cerebral cortex of rat brains. Aluminium treated animals showed presence of ghost cells, vacuolated cytoplasm and haemorrhage in rat cerebral cortex, indicating neurotoxicity. Nebivolol attenuated all these changes. Thus, the potential of nebivolol to prevent aluminium-induced neurotoxicity was also reflected at microscopic level, indicative of its neuroprotective effects. Conclusion: Nebivolol showed significant antioxidant and neuroprotective activities against aluminium-induced neuronal degeneration. The results of the present study strengthen oxidative stress hypothesis of aluminium-induced neurotoxicity and suggest beneficial role of nebivolol in the treatment of neurodegenerative disorders

Reconstruction Methods for Providing Privacy in Data Mining

Data mining is the process of finding correlations or patterns among the dozens of fields in large database. A fruitful direction for data mining research will be the development of techniques that incorporate privacy concerns. Since primary task in our paper is that accurate data which we retrieve should be somewhat changed while providing to users. For this reason, recently much research effort has been devoted for addressing the problem of providing security in data mining. We consider the concrete case of building a decision tree classifier from data in which the values of individual records have been reconstructed. The resulting data records look very different from the original records and the distribution of data values is also very different from the original distribution. By using these reconstructed distribution we are able to build classifiers whose accuracy is comparable to the accuracy of classifiers built with the original data

Comparison of cardiovascular safety of escitalopram and sertraline based on electrocardiographic alterations: a pharmacovigilance study

Background: Escitalopram and sertraline are the most commonly prescribed antidepressant drugs, belongs to SSRI class. Both the drugs are long been considered as free from cardiovascular adverse effects. Recently number of studies reported potential association between these drugs and pronounced cardiovascular adverse effects. ECG changes like prolongation of QT interval are frequently used as markers for the increased risk of a fatal cardiac arrhythmia. The potential cardiovascular adverse reaction profile of both these drugs is little studied in Indian rural population.Methods: This was a 6 weeks prospective open label observational study carried out in a drug naive 209 patients receiving either escitalopram (n=106) or sertraline (n=103). ECG parameters like heart rate, RR interval, PQ/PR interval, QRS duration and QTc interval, were obtained directly from the digital machine recordings, additionally the QT interval was measured manually with the help of caliper. Statistical analysis was done by using Statistical software SPSS 17.0.Results: Out of 209 drugs naive patients, 12 from escitalopram group and 10 patients from Sertraline were lost to follow-up. Hence ECG recordings of the remaining 94 patients under escitalopram group, 93 patients under sertraline group were used for study analysis. The ECG alterations caused by the escitalopram were compared with that caused by sertraline. It was observed that the differences between the ECG alterations caused by either of escitalopram or sertraline were statistically non-significant.Conclusions: It was concluded, at therapeutic doses neither of the drugs have the potential risk of drug induced arrhythmias, throughout the study. 

Phytochemical investigation and anti-Inflammatory activity of Coccinia indica wight and arn. (Cucurbitaceae) fruits

The present work was to study the anti-inflammatory activity of Coccinia indica Wight and Arn fruits belonging to family Cucurbitaceae. The fruit powder of C. indica was subjected to successive extraction with petroleum ether, chloroform, ethanol and water in a Soxhlet extractor. The ethanol extract after preliminary phytochemical investigation shown the presence of glycosides, triterpenoids, flavonoids, tannins and phenolic compounds. The anti-inflammatory activity was studied using carrageenan-induced rat paw oedema and cotton pellet granuloma at three different doses (100, 200 and 400 mg/kg b.w. p.o.) of each extract. The ethanol extract of C. indica fruits exhibited significant anti-inflammatory activity at the dose of 200 mg/kg and 400 mg/kg in both models when compared with control group. Indomethacin (10 mg/kg b.w. p.o) also showed significant anti-inflammatory activity in both models.Colegio de Farmacéuticos de la Provincia de Buenos Aire

Association of Genetic Variants in XPC and XPG Genes with Cervical Cancer Risk in a Rural Population: A Hospital Based Case Control Study

Background: Cervical cancer is a major concern of health risk in urban and rural parts of India.. Aim and Objectives: This study was aimed to find out frequency of polymorphisms in DNA repair genes including Xeroderma pigmentosum complementation group C (XPC) and Xenoderma pigmentosum complementation group G (XPG) in patients of cervical cancer from Maharashtra and to evaluate their association with risk of cervical cancer. Materials and Methods: We used polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) to examine gene polymorphisms in 350 patients with cancer of cervix and 400 age and sex matched normal controls. Results: The results obtained indicated that there was no significant difference in the genotype distribution between cervical cancer patients and controls for XPC Lys939Gln, -371promoter and XPG His 1104 Asp. The result showed that genotype frequencies of XPC Val 499 Arg of codon 499 in exon 15 (OR=4.26; 95% CI=(3.007-6.03); p= <0.0001) were increased significantly. Conclusion: This study indicates that polymorphisms in Val499Arg haplotype of XPC gene appear to influence genetic susceptibility of individual to cervical cancer in Maharashtrian patients