Increasing frequencies and changing characteristics of heavy precipitation events threatening infrastructure in Europe under climate change

The effect of climate change on potentially infrastructure-damaging heavy precipitation events in Europe is investigated in an ensemble of regional climate simulations conducted at a horizontal resolution of 12 km. Based on legislation and stakeholder interviews the 10-year return period is used as a threshold for the detection of relevant events. A novel technique for the identification of heavy precipitation events is introduced. It records not only event frequency but also event size, duration and severity (a measure taking duration, size and rain amount into account) as these parameters determine the potential consequences of the event. Over most of Europe the frequency of relevant heavy precipitation events is predicted to increase with increasing greenhouse gas concentrations. The number of daily and multi-day events increases at a lower rate than the number of sub-daily events. The event size is predicted to increase in the future over many European regions, especially for sub-daily events. Moreover, the most severe events were detected in the projection period. The predicted changes in frequency, size and intensity of events may increase the risk for infrastructure damages. The climate change simulations do not show changes in event duration

Best practices for addressing missing data through multiple imputation

A common challenge in developmental research is the amount of incomplete and missing data that occurs from respondents failing to complete tasks or questionnaires, as well as from disengaging from the study (i.e., attrition). This missingness can lead to biases in parameter estimates and, hence, in the interpretation of findings. These biases can be addressed through statistical techniques that adjust for missing data, such as multiple imputation. Although multiple imputation is highly effective, it has not been widely adopted by developmental scientists given barriers such as lack of training or misconceptions about imputation methods. Utilizing default methods within statistical software programs like listwise deletion is common but may introduce additional bias. This manuscript is intended to provide practical guidelines for developmental researchers to follow when examining their data for missingness, making decisions about how to handle that missingness and reporting the extent of missing data biases and specific multiple imputation procedures in publications

A draft human pangenome reference

Here the Human Pangenome Reference Consortium presents a first draft of the human pangenome reference. The pangenome contains 47 phased, diploid assemblies from a cohort of genetically diverse individuals. These assemblies cover more than 99% of the expected sequence in each genome and are more than 99% accurate at the structural and base pair levels. Based on alignments of the assemblies, we generate a draft pangenome that captures known variants and haplotypes and reveals new alleles at structurally complex loci. We also add 119 million base pairs of euchromatic polymorphic sequences and 1,115 gene duplications relative to the existing reference GRCh38. Roughly 90 million of the additional base pairs are derived from structural variation. Using our draft pangenome to analyse short-read data reduced small variant discovery errors by 34% and increased the number of structural variants detected per haplotype by 104% compared with GRCh38-based workflows, which enabled the typing of the vast majority of structural variant alleles per sample

Uitspraak Uitgelicht - Het belang van het kind voorop bij Dublinprocedures?

Item does not contain fulltex

Noot bij: ABRvS 27 mei 2020, 2020, (Het belang van het kind voorop bij Dublinprocedures?)

Item does not contain fulltext27 mei 202

Severe marine storms in the Northern Adriatic: Characteristics and trends

This paper discusses present characteristics and trends of marine storminess in the Northern Adriatic. It merges oceanographic and meteorological aspects, by considering storm surges, wind waves and the atmospheric cyclones that cause them. The paper describes the dynamics of these three processes, the different role of south-easterly (Sirocco) and easterly (Bora) wind regimes. The specific characteristics of cyclones producing severe marine storms in terms of location where cyclogenesis occurs, trajectories and intensity, are compared with those of generic cyclones crossing northern Italy. It is shown that cyclones producing high waves and surges have different characteristics and their lists overlap only partially. However, both high wave and surge events have a similar annual cycle, with maximum activity in November and hardly any event in summer (June-July-August). The trends of severe high wave and surge events are discussed (various thresholds are considered) and they are shown to be consistent. Timeseries, which show large interannual variability and very little overall tendencies on multi-decadal time scale, are suggestive of progressively milder storms during the second half of the 20th century