74 research outputs found
Monte Carlo Calculations for Liquid He at Negative Pressure
A Quadratic Diffusion Monte Carlo method has been used to obtain the equation
of state of liquid He including the negative pressure region down to the
spinodal point. The atomic interaction used is a renewed version (HFD-B(HE)) of
the Aziz potential, which reproduces quite accurately the features of the
experimental equation of state. The spinodal pressure has been calculated and
the behavior of the sound velociy around the spinodal density has been
analyzed.Comment: 10 pages, RevTex 3.0, with 4 PostScript figures include
A draft human pangenome reference
Here the Human Pangenome Reference Consortium presents a first draft of the human pangenome reference. The pangenome contains 47 phased, diploid assemblies from a cohort of genetically diverse individuals. These assemblies cover more than 99% of the expected sequence in each genome and are more than 99% accurate at the structural and base pair levels. Based on alignments of the assemblies, we generate a draft pangenome that captures known variants and haplotypes and reveals new alleles at structurally complex loci. We also add 119 million base pairs of euchromatic polymorphic sequences and 1,115 gene duplications relative to the existing reference GRCh38. Roughly 90 million of the additional base pairs are derived from structural variation. Using our draft pangenome to analyse short-read data reduced small variant discovery errors by 34% and increased the number of structural variants detected per haplotype by 104% compared with GRCh38-based workflows, which enabled the typing of the vast majority of structural variant alleles per sample
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