The Dual Origin of Stellar Halos II: Chemical Abundances as Tracers of Formation History

Fully cosmological, high resolution N-Body + SPH simulations are used to investigate the chemical abundance trends of stars in simulated stellar halos as a function of their origin. These simulations employ a physically motivated supernova feedback recipe, as well as metal enrichment, metal cooling and metal diffusion. As presented in an earlier paper, the simulated galaxies in this study are surrounded by stellar halos whose inner regions contain both stars accreted from satellite galaxies and stars formed in situ in the central regions of the main galaxies and later displaced by mergers into their inner halos. The abundance patterns ([Fe/H] and [O/Fe]) of halo stars located within 10 kpc of a solar-like observer are analyzed. We find that for galaxies which have not experienced a recent major merger, in situ stars at the high [Fe/H] end of the metallicity distribution function are more [alpha/Fe]-rich than accreted stars at similar [Fe/H]. This dichotomy in the [O/Fe] of halo stars at a given [Fe/H] results from the different potential wells within which in situ and accreted halo stars form. These results qualitatively match recent observations of local Milky Way halo stars. It may thus be possible for observers to uncover the relative contribution of different physical processes to the formation of stellar halos by observing such trends in the halo populations of the Milky Way, and other local L* galaxies.Comment: Version accepted for publication in ApJ Part 1. This version of the paper has been extended to include a detailed discussion of numerical issue

Classifying elephant behaviour through seismic vibrations

Seismic waves — vibrations within and along the Earth’s surface — are ubiquitous sources of information. During propagation, physical factors can obscure information transfer via vibrations and influence propagation range [1]. Here, we explore how terrain type and background seismic noise influence the propagation of seismic vibrations generated by African elephants. In Kenya, we recorded the ground-based vibrations of different wild elephant behaviours, such as locomotion and infrasonic vocalisations [2], as well as natural and anthropogenic seismic noise. We employed techniques from seismology to transform the geophone recordings into source functions — the time-varying seismic signature generated at the source. We used computer modelling to constrain the propagation ranges of elephant seismic vibrations for different terrains and noise levels. Behaviours that generate a high force on a sandy terrain with low noise propagate the furthest, over the kilometre scale. Our modelling also predicts that specific elephant behaviours can be distinguished and monitored over a range of propagation distances and noise levels. We conclude that seismic cues have considerable potential for both behavioural classification and remote monitoring of wildlife. In particular, classifying the seismic signatures of specific behaviours of large mammals remotely in real time, such as elephant running, could inform on poaching threats

High-Resolution Spectroscopy of Extremely Metal-Poor Stars in the Least Evolved Galaxies: Ursa Major II and Coma Berenices

We present Keck/HIRES observations of six metal-poor stars in two of the ultra-faint dwarf galaxies orbiting the Milky Way, Ursa Major II and Coma Berenices. These observations include the first high-resolution spectroscopic observations of extremely metal-poor stars ([Fe/H]<-3.0) stars not belonging to the Milky Way (MW) halo field star population. We obtain abundance measurements and upper limits for 26 elements between carbon and europium. The entire sample of stars spans a range of -3.2<[Fe/H]<-2.3, and we confirm that each galaxy contains a large intrinsic spread of Fe abundances. A comparison with MW halo stars of similar metallicities reveals substantial agreement between the abundance patterns of the ultra-faint dwarf galaxies and the MW halo for the light, alpha and iron-peak elements (C to Zn). This agreement contrasts with the results of earlier studies of more metal-rich stars (-2.5<[Fe/H]<-1.0) in more luminous dwarf spheroidal galaxies (dSphs), which found significant abundance discrepancies with respect to the MW halo data. The abundances of neutron-capture elements (Sr to Eu) in the ultra-faint dwarf galaxies are extremely low, consistent with the most metal-poor halo stars, but not with the typical halo abundance pattern at [Fe/H]>-3.0. Our results are broadly consistent with a galaxy formation model that predicts that massive dwarf galaxies are the source of the metal-rich component ([Fe/H]>-2.5) of the MW halo, but we also suggest that the faintest known dwarfs may be the primary contributors to the metal-poor end of the MW halo metallicity distribution.Comment: Accepted for publication in ApJ, emulateapj-style, 29 pages incl. figures and table

Models of classroom assessment for course-based research experiences

Course-based research pedagogy involves positioning students as contributors to authentic research projects as part of an engaging educational experience that promotes their learning and persistence in science. To develop a model for assessing and grading students engaged in this type of learning experience, the assessment aims and practices of a community of experienced course-based research instructors were collected and analyzed. This approach defines four aims of course-based research assessment—(1) Assessing Laboratory Work and Scientific Thinking; (2) Evaluating Mastery of Concepts, Quantitative Thinking and Skills; (3) Appraising Forms of Scientific Communication; and (4) Metacognition of Learning—along with a set of practices for each aim. These aims and practices of assessment were then integrated with previously developed models of course-based research instruction to reveal an assessment program in which instructors provide extensive feedback to support productive student engagement in research while grading those aspects of research that are necessary for the student to succeed. Assessment conducted in this way delicately balances the need to facilitate students’ ongoing research with the requirement of a final grade without undercutting the important aims of a CRE education

Effect of Physical Activity Level on Biomarkers of Inflammation and Insulin Resistance Over 5 Years in Outpatients With Coronary Heart Disease (from the Heart and Soul Study)

Higher levels of physical activity are associated with lower rates of coronary heart disease (CHD). Prior studies suggest this is partly due to lower levels of inflammation and insulin resistance. We sought to determine whether physical activity level was associated with inflammation or insulin resistance during a 5-year period in outpatients with known CHD. We evaluated 656 participants from the Heart and Soul Study, a prospective cohort study of outpatients with documented CHD. Self-reported physical activity frequency was assessed at baseline and after 5 years of follow-up. Participants were classified as low versus high activity at each visit, yielding 4 physical activity groups: stable low activity, decreasing activity (high at baseline to low at Year 5), increasing activity (low at baseline to high at Year 5), and stable high activity. We compared Year 5 markers of inflammation (C-reactive protein [CRP], interleukin-6, and fibrinogen) and insulin resistance (insulin, glucose, and A1c) across the 4 activity groups. After 5-years of follow-up, higher activity was associated with lower mean levels of all biomarkers. In the fully adjusted regression models CRP, interleukin-6, and glucose remained independently associated with physical activity frequency (log CRP p-trend across activity groups = 0.03; log interleukin-6 p-trend = 0.01; log glucose p-trend = 0.003). Individuals with Stable High Activity typically had the lowest levels of biomarkers. In conclusion, in this novel population of outpatients with known CHD followed for 5 years, higher physical activity frequency was independently associated with lower levels of CRP, interleukin-6, and glucose

An open-label, single-arm pilot study of EUS-guided brachytherapy with phosphorus-32 microparticles in combination with gemcitabine +/- nab-paclitaxel in unresectable locally advanced pancreatic cancer (OncoPaC-1): Technical details and study protocol.

Current treatment options for patients with unresectable locally advanced pancreatic cancer (LAPC) include chemotherapy alone or followed by chemoradiation or stereotactic body radiotherapy. However, the prognosis for these patients remains poor, with a median overall survival &lt;12 months. Therefore, novel treatment options are needed. Currently, there is no brachytherapy device approved for pancreatic cancer treatment. Hereby, we present the protocol of a prospective, multicenter, interventional, open-label, single-arm pilot study (OncoPac-1, Clinicaltrial.gov-NCT03076216) aiming to determine the safety and efficacy of Phosphorus-32 when implanted directly into pancreatic tumors using EUS guidance, for patients with unresectable LAPC undergoing chemotherapy (gemcitabine ± nab-paclitaxel)