4 research outputs found
Silicon Nanowire Sensors Enable Diagnosis of Patients via Exhaled Breath
Two of the biggest challenges in medicine today are the need to detect diseases in a noninvasive manner and to differentiate between patients using a single diagnostic tool. The current study targets these two challenges by developing a molecularly modified silicon nanowire field effect transistor (SiNW FET) and showing its use in the detection and classification of many disease breathprints (lung cancer, gastric cancer, asthma, and chronic obstructive pulmonary disease). The fabricated SiNW FETs are characterized and optimized based on a training set that correlate their sensitivity and selectivity toward volatile organic compounds (VOCs) linked with the various disease breathprints. The best sensors obtained in the training set are then examined under real-world clinical conditions, using breath samples from 374 subjects. Analysis of the clinical samples show that the optimized SiNW FETs can detect and discriminate between almost all binary comparisons of the diseases under examination with >80% accuracy. Overall, this approach has the potential to support detection of many diseases in a direct harmless way, which can reassure patients and prevent numerous unpleasant investigations
Ultrasensitive Silicon Nanowire for Real-World Gas Sensing: Noninvasive Diagnosis of Cancer from Breath Volatolome
We
report on an ultrasensitive, molecularly modified silicon nanowire
field effect transistor that brings together the lock-and-key and
cross-reactive sensing worlds for the diagnosis of (gastric) cancer
from exhaled volatolome. The sensor is able to selectively detect
volatile organic compounds (VOCs) that are linked with gastric cancer
conditions in exhaled breath and to discriminate them from environmental
VOCs that exist in exhaled breath samples but do not relate to the
gastric cancer per se. Using breath samples collected from actual
patients with gastric cancer and from volunteers who do not have cancer,
blind analysis validated the ability of the reported sensor to discriminate
between gastric cancer and control conditions with >85% accuracy,
irrespective of important confounding factors such as tobacco consumption
and gender. The reported sensing approach paves the way to use the
power of silicon nanowires for simple, inexpensive, portable, and
noninvasive diagnosis of cancer and other disease conditions
Silicon Nanowire Sensors Enable Diagnosis of Patients <i>via</i> Exhaled Breath
Two
of the biggest challenges in medicine today are the need to detect
diseases in a noninvasive manner and to differentiate between patients
using a single diagnostic tool. The current study targets these two
challenges by developing a molecularly modified silicon nanowire field
effect transistor (SiNW FET) and showing its use in the detection
and classification of many disease breathprints (lung cancer, gastric
cancer, asthma, and chronic obstructive pulmonary disease). The fabricated
SiNW FETs are characterized and optimized based on a training set
that correlate their sensitivity and selectivity toward volatile
organic compounds (VOCs) linked with the various disease breathprints. The best sensors
obtained in the training set are then examined under real-world clinical
conditions, using breath samples from 374 subjects. Analysis of the
clinical samples show that the optimized SiNW FETs can detect and
discriminate between almost all binary comparisons of the diseases
under examination with >80% accuracy. Overall, this approach has
the potential to support detection of many diseases in a direct harmless
way, which can reassure patients and prevent numerous unpleasant investigations