Association of blood pressure and renal outcome in patients with chronic kidney disease; a post hoc analysis of FROM-J study

It is well-known that hypertension exacerbates chronic kidney disease (CKD) progression, however, the optimal target blood pressure (BP) level in patients with CKD remains unclear. This study aimed to assess the optimal BP level for preventing CKD progression. The risk of renal outcome among different BP categories at baseline as well as 1 year after, were evaluated using individual CKD patient data aged between 40 and 74 years from FROM-J [Frontier of Renal Outcome Modifications in Japan] study. The renal outcome was defined as >= 40% reduction in estimated glomerular filtration rate to130 mmHg group. A significant increase in the renal outcome was found only in the group of diastolic BP >= 90 mmHg. The group of BP= 130 mmHg at baseline. Targeting SBP level<130 mmHg would be associated with the preferable renal outcome.Clinical Trial Registration-URL: https://www.umin.ac.jp/ctr/. Unique identifier: UMIN000001159 (16/05/2008)

Stereoisomer Discrimination of Some Amino Sugars: Chiral Recognition FAB Mass Spectrometry Coupled with the Enantiomer-Labeled Host Method

FAB mass spectrometry coupled with the host-guest complexation method was used to distinguish some amino sugars (1-8) including glucosamine, galactosamine, and mannosamine, etc. The method characteristically used a 1:1 mixture of the chiral crown ether host whose enantiomer was isotopically labeled. Diastereomer differentiation of a given amino sugar salt (G+) was simply measured with a given host pair (A or B) (HRRRR:HSSSS-d6=1:1) from the peak intensity ratio of the two diastereomeric host-guest complex ions as I[(HRRRR+G)+]/I[(HSSSS-d6+G)+]≡IRIS (abbreviation). The stereoisomer differentiation was performed by the IRIS values in the range from 0.4 to 2.0 (for the use of the host pair A) and from 0.4 to 3.4 (for the use of the host pair B). The five underivatized amino sugar hydrochloride salts (1-5) were successfully differentiated using the present chiral recognition FAB mass spectrometry. The stereoisomer-(13C)-labeled guest method was also presensed to evaluate their relative complexation abilities

Precise Measurement of Clearance between Two Substrates Using Evanescent Waves

In the material designing process of footwear outer-soles, the rubber grip property under lubricated conditions is important. Generally, friction behaviors of rubber under such conditions are influenced by contact states, which can be changed by various factors, i.e. viscosity, sliding velocity, normal force, surface roughness and wettability between two substrates. To discuss the influences of each parameter, the contact conditions are investigated. The purpose of this study is to establish a new method to measure the distributions of real contact area and film thickness between two substrates based on the decay behavior of an evanescent field in a total reflection method. In conclusion, film thickness was measured with an accuracy of 1 nm in a range of clearance of less than 800 nm

Influence of Dewettability on Rubber Friction Properties with Different Surface Roughness under Water/Ethanol/Glycerol Lubricated Conditions

In the material designing process of footwear outer-soles, a grip property of rubber is of crucial importance under water or oil lubricated condition. In general, contact states between rubber and floors under lubricated conditions are influenced by various factors, i. e. viscosity of a lubricant, sliding velocity, normal force, surface roughness and wettability between the two substrates. It has been said that lubrication conditions can be distinguished based on Stribeck curves, which are described by the relationship between Sommerfeld numbers and dynamic friction coefficients. Wettability under the static condition is estimated by the spreading coefficient, which is used to evaluate the energy balance of interface free energies at a triple line. The purpose of this study is to investigate influences of surface free energies, viscosities, sliding velocities and surface roughnesses on dynamic friction coefficients of rubber under lubricated conditions. The influences of spreading coefficients on the behaviors of Stribeck curves and the relationship between dewetting velocities and dynamic friction coefficients are also discussed