Packing defects and the width of biopolymer bundles

The formation of bundles composed of actin filaments and cross-linking proteins is an essential process in the maintenance of the cells' cytoskeleton. It has also been recreated by in-vitro experiments, where actin networks are routinely produced to mimic and study the cellular structures. It has long been observed that these bundles seem to have a well defined width distribution, which has not been adequately described theoretically. We propose here that packing defects of the filaments, quenched and random, contribute an effective repulsion that counters the cross-linking adhesion energy and leads to a well defined bundle width. This is a two-dimensional strain-field version of the classic Rayleigh instability of charged droplets

Probing Supersymmetric Flavor Models with ϵ′/ϵ\epsilon'/\epsilon

We discuss the supersymmetric contribution to $\epsilon'/\epsilon$ in various supersymmetric flavor models. We find that in alignment models the supersymmetric contribution could be significant while in heavy squark models it is expected to be small. The situation is particularly interesting in models that solve the flavor problems by either of the above mechanisms and the remaining CP problems by means of approximate CP, that is, all CP violating phases are small. In such models, the standard model contributions cannot account for $\epsilon'/\epsilon$ and a failure of the supersymmetric contributions to do so would exclude the model. In models of alignment and approximate CP, the supersymmetric contributions can account for $\epsilon'/\epsilon$ only if both the supersymmetric model parameters and the hadronic parameters assume rather extreme values. Such models are then strongly disfavored by the $\epsilon'/\epsilon$ measurements. Models of heavy squarks and approximate CP are excluded.Comment: 16 pages, harvmac. v2: We added a discussion of the intriguing implications that would follow if a recent lattice result is confirme

Superheavy Supersymmetry from Scalar Mass--A Parameter Fixed Points

In supersymmetric models, the well-known tension between naturalness and experimental constraints is relieved if the squarks and sleptons of the first two generations are superheavy, with masses of order 10 TeV, and all other superpartners are light, with masses of order 1 TeV. We show that even if all scalar masses and trilinear A parameters are of order 10 TeV at some high scale, a mass-squared hierarchy of order 400 may be generated dynamically through renormalization group evolution. The required high energy relations are consistent with grand unification, or, alternatively, may be realized in moduli-dominated supersymmetry-breaking scenarios.Comment: 12 pages, 3 figure

Self-Improving Algorithms

We investigate ways in which an algorithm can improve its expected performance by fine-tuning itself automatically with respect to an unknown input distribution D. We assume here that D is of product type. More precisely, suppose that we need to process a sequence I_1, I_2, ... of inputs I = (x_1, x_2, ..., x_n) of some fixed length n, where each x_i is drawn independently from some arbitrary, unknown distribution D_i. The goal is to design an algorithm for these inputs so that eventually the expected running time will be optimal for the input distribution D = D_1 * D_2 * ... * D_n. We give such self-improving algorithms for two problems: (i) sorting a sequence of numbers and (ii) computing the Delaunay triangulation of a planar point set. Both algorithms achieve optimal expected limiting complexity. The algorithms begin with a training phase during which they collect information about the input distribution, followed by a stationary regime in which the algorithms settle to their optimized incarnations.Comment: 26 pages, 8 figures, preliminary versions appeared at SODA 2006 and SoCG 2008. Thorough revision to improve the presentation of the pape

Sequestering CP Violation and GIM-Violation with Warped Extra Dimensions

We propose a model of spontaneous CP violation to address the strong CP problem in warped extra dimensions that relies on sequestering flavor and CP violation. We assume that brane-localized Higgs Yukawa interactions respect a U(3) flavor symmetry that is broken only by bulk fermion mass and Yukawa terms. All CP violation arises from the vev of a CP-odd scalar field localized in the bulk. To suppress radiative corrections to theta-bar, the doublet quarks in this model are localized on the IR brane. We calculate constraints from flavor-changing neutral currents (FCNCs), precision electroweak measurements, CKM unitarity, and the electric dipole moments in this model and predict theta-bar to be at least about 10^-12.Comment: 38 page

A possible supersymmetric solution to the discrepancy between B -> \phi K_S and B -> \eta' K_S CP asymmetries

We present a possible supersymmetric solution to the discrepancy between the observed mixing CP asymmetries in B -> \phi K_S and B -> \eta' K_S. We show that due to the different parity in the final states of these processes, their supersymmetric contributions from the R-sector have an opposite sign, which naturally explain the large deviation between S_{\phi K_S} and S_{\eta' K_S}. We also consider the proposed mechanisms to solve the puzzle of the observed large branching ratio of B -> \eta' K and study their impact on S_{eta' K_S}.Comment: 4 pages, 2 figure

Solid-state electronic spin coherence time approaching one second

Solid-state electronic spin systems such as nitrogen-vacancy (NV) color centers in diamond are promising for applications of quantum information, sensing, and metrology. However, a key challenge for such solid-state systems is to realize a spin coherence time that is much longer than the time for quantum spin manipulation protocols. Here we demonstrate an improvement of more than two orders of magnitude in the spin coherence time ($T_2$) of NV centers compared to previous measurements: $T_2 \approx 0.5$ s at 77 K, which enables $\sim 10^7$ coherent NV spin manipulations before decoherence. We employed dynamical decoupling pulse sequences to suppress NV spin decoherence due to magnetic noise, and found that $T_2$ is limited to approximately half of the longitudinal spin relaxation time ($T_1$) over a wide range of temperatures, which we attribute to phonon-induced decoherence. Our results apply to ensembles of NV spins and do not depend on the optimal choice of a specific NV, which could advance quantum sensing, enable squeezing and many-body entanglement in solid-state spin ensembles, and open a path to simulating a wide range of driven, interaction-dominated quantum many-body Hamiltonians

Environmental market factors associated with electronic health record adoption among cancer hospitals

Background: Although recent literature has explored the relationship between various environmental market characteristics and the adoption of electronic health records (EHRs) among general, acute care hospitals, no such research currently exists for specialty hospitals, including those providing cancer care. Purpose: The aim of the study was to examine the relationship between market characteristics and the adoption of EHRs among Commission on Cancer (CoC)-accredited hospitals. Methods/Approach: Secondary data on EHR adoption combined with hospital and environmental market characteristics were analyzed using logistic regression. Using the resource dependence theory, we examined how measures of munificence, complexity, and dynamism are related to the adoption of EHRs among CoC-accredited hospitals and, separately, hospitals not CoC-accredited. Findings: In a sample of 2,670 hospitals, 141 (0.05%) were academic-based CoC-accredited hospitals and 562 (21%) were community-based CoC-accredited hospitals. Measures of munificence such as cancer incidence rates (OR = 0.99, CI [0.99, 1.00], p = .020) and percentage population aged 65+ (OR = 0.99, CI [0.99, 1.00], p = .001) were negatively associated with basic EHR adoption, whereas urban location was positively associated with comprehensive EHR adoption (OR = 3.07, CI [0.89, 10.61], p = .076) for community-based CoC-accredited hospitals. Measures of complexity such as hospitals in areas with less competition were less likely to adopt a basic EHR (OR = 0.33, CI [0.19, 0.96], p = .005), whereas Medicare Managed Care penetration was positively associated with comprehensive EHR adoption (OR = 1.02, CI [1.00, 1.05], p = .070) among community-based CoC-accredited hospitals. Lastly, dynamism, measured as population change, was negatively associated with the adoption of comprehensive EHRs (OR = 0.99, CI [0.99, 1.00], p = .070) among academic-based CoC-accredited hospitals. Practice implications: A greater understanding of the environment’s relationship to health information technology adoption in cancer hospitals will help stakeholders in these institutions make informed strategic decisions about information technology investments guided by their facilities’ respective environmental factors. The results of this study may also be useful to hospital chief information officers and chief executive officers seeking to either improve their quality of care or achieve and maintain accreditation in providing cancer care

CP Violation in D0−D0‾D^0-\overline{D^0}Mixing

The existence of $D^0-\overline{D^0}$ mixing at a detectable level requires new physics, which effectively yields a $\Delta c = 2$ superweak interaction. In general this interaction may involve significant CP violation. For small values of the mixing it may be much easier to detect the CP-violating part of the mixing than the CP-conserving part.Comment: 3 pages, latex, no figure