The Science Performance of JWST as Characterized in Commissioning

This paper characterizes the actual science performance of the James Webb Space Telescope (JWST), as determined from the six month commissioning period. We summarize the performance of the spacecraft, telescope, science instruments, and ground system, with an emphasis on differences from pre-launch expectations. Commissioning has made clear that JWST is fully capable of achieving the discoveries for which it was built. Moreover, almost across the board, the science performance of JWST is better than expected; in most cases, JWST will go deeper faster than expected. The telescope and instrument suite have demonstrated the sensitivity, stability, image quality, and spectral range that are necessary to transform our understanding of the cosmos through observations spanning from near-earth asteroids to the most distant galaxies.Comment: 5th version as accepted to PASP; 31 pages, 18 figures; https://iopscience.iop.org/article/10.1088/1538-3873/acb29

Arts in Health in the Netherlands:A national agenda

Arts in health is the field that advances the use of artistic practices for health and well-being, to stimulate a positive approach to health. While arts in health fields have been successfully established in other countries, the Dutch field is still fragmented, and its potential has not been fully developed.This white paper is an intersectoral effort exploring the current state of arts in health in the Netherlands. The authors strongly believe that arts in health can help navigate challenges faced by our healthcare system in the coming decades, and we have formulated an agenda to establish a sustainable Dutch arts in health field.Arts in health is the field that advances the use of artistic practices for health and well-being, to stimulate a positive approach to health. While arts in health fields have been successfully established in other countries, the Dutch field is still fragmented, and its potential has not been fully developed.This white paper is an intersectoral effort exploring the current state of arts in health in the Netherlands. The authors strongly believe that arts in health can help navigate challenges faced by our healthcare system in the coming decades, and we have formulated an agenda to establish a sustainable Dutch arts in health field

Arts in Health in the Netherlands:A national agenda

Arts in health verwijst naar het veld dat artistieke en creatieve praktijken toepast om gezondheid en welzijn te bevorderen en een positieve benadering van gezondheid te stimuleren. Terwijl arts in health internationaal al decennialang een gevestigd veld is in andere landen, is het Nederlandse veld nog steeds gefragmenteerd en blijft het groeiende potentieel ervan onderbenut. Deze whitepaper is een intersectorale verkenning van de huidige stand van zaken op het gebied van arts in health in Nederland. De auteurs zijn ervan overtuigd dat arts in health kan helpen om de grote uitdagingen waar onze gezondheidszorg de komende decennia voor staat, het hoofd te bieden en hebben een agenda geformuleerd voor het verduurzamen van het veld voor arts in health in Nederland.Arts in health is the field that advances the use of artistic practices for health and well-being, to stimulate a positive approach to health. While arts in health fields have been successfully established in other countries, the Dutch field is still fragmented, and its potential has not been fully developed.This white paper is an intersectoral effort exploring the current state of arts in health in the Netherlands. The authors strongly believe that arts in health can help navigate challenges faced by our healthcare system in the coming decades, and we have formulated an agenda to establish a sustainable Dutch arts in health field

Arts in Health in the Netherlands:A national agenda

Arts in health verwijst naar het veld dat artistieke en creatieve praktijken toepast om gezondheid en welzijn te bevorderen en een positieve benadering van gezondheid te stimuleren. Terwijl arts in health internationaal al decennialang een gevestigd veld is in andere landen, is het Nederlandse veld nog steeds gefragmenteerd en blijft het groeiende potentieel ervan onderbenut. Deze whitepaper is een intersectorale verkenning van de huidige stand van zaken op het gebied van arts in health in Nederland. De auteurs zijn ervan overtuigd dat arts in health kan helpen om de grote uitdagingen waar onze gezondheidszorg de komende decennia voor staat, het hoofd te bieden en hebben een agenda geformuleerd voor het verduurzamen van het veld voor arts in health in Nederland.Arts in health is the field that advances the use of artistic practices for health and well-being, to stimulate a positive approach to health. While arts in health fields have been successfully established in other countries, the Dutch field is still fragmented, and its potential has not been fully developed.This white paper is an intersectoral effort exploring the current state of arts in health in the Netherlands. The authors strongly believe that arts in health can help navigate challenges faced by our healthcare system in the coming decades, and we have formulated an agenda to establish a sustainable Dutch arts in health field

Antigen presentation by B cells enables epitope spreading across an MHC barrier

Abstract Circumstantial evidence suggests that B cells may instruct T cells to break tolerance. Here, to test this hypothesis, we used a murine model in which a single B cell clone precipitates an autoreactive response resembling systemic lupus erythematosus (SLE). The initiating clone did not need to enter germinal centers to precipitate epitope spreading. Rather, it localized to extrafollicular splenic bridging channels early in the response. Autoantibody produced by the initiating clone was not sufficient to drive the autoreactive response. Subsequent epitope spreading depended on antigen presentation and was compartmentalized by major histocompatibility complex (MHC). B cells carrying two MHC haplotypes could bridge the MHC barrier between B cells that did not share MHC. Thus, B cells directly relay autoreactivity between two separate compartments of MHC-restricted T cells, leading to inclusion of distinct B cell populations in germinal centers. Our findings demonstrate that B cells initiate and propagate the autoimmune response

The Science Performance of JWST as Characterized in Commissioning

This paper characterizes the actual science performance of the James Webb Space Telescope (JWST), as determined from the six month commissioning period. We summarize the performance of the spacecraft, telescope, science instruments, and ground system, with an emphasis on differences from pre-launch expectations. Commissioning has made clear that JWST is fully capable of achieving the discoveries for which it was built. Moreover, almost across the board, the science performance of JWST is better than expected; in most cases, JWST will go deeper faster than expected. The telescope and instrument suite have demonstrated the sensitivity, stability, image quality, and spectral range that are necessary to transform our understanding of the cosmos through observations spanning from near-earth asteroids to the most distant galaxies