Synthesis, characterization and investigation of photochemical and in vitro antiproliferative properties of novel Zn(II) phthalocyanine

In this study, a novel peripheral zinc(II) phthalocyanine (ZnPc) containing cyclic two triazole moieties which include 24 or 26-membered macrocyclic zinc(II) phthalocyanine was synthesized via multistep reactions. The precursor macrocyclic phthalonitrile was converted into the related phthalocyanine by cyclotetramerization reaction. The photochemical, in-silico selective targeting of cancer related genes and in vitro antiproliferative effect of this zinc(II) phthalocyanine was investigated. Singlet oxygen production properties of the synthesized phthalocyanine compound (ZnPc) indicated as singlet oxygen quantum yield (Phi(delta) = 0.47). In-silico studies proved the efficient and specific binding capability of G-quadruplex nucleic acids. ZnPc compound demonstrated antiproliferative effect in vitro on human non-small cell lung carcinoma cell lines. (C) 2022 Elsevier B.V. All rights reserved.Scientific and Technological Coun- cil of Turkey (Ankara -Turkey) [114Z441]Authors are thankful to The Scientific and Technological Coun- cil of Turkey (Ankara -Turkey) for financial support (Project No: 114Z441)

Synthesis, characterization and structural computational investigation of novel Zn(II)phthalocyanines containing peripheral anthracene moieties

WOS: 000484115800021New zinc(II)phthalocyanines (ZnPc-I and ZnPc-II) containing four peripheral anthracene pendant groups were synthesized by cyclotetramerization of (E)-4-(3-(4-((anthracen-9-yl-methylene) amino)phenoxy)propoxy)phthalonitrile and 4-(3-(4-((anthracen-9-ylmethyl)amino)phenoxy)propoxy) phthalonitrile. All compounds were characterized using a combination of analytical and spectroscopic techniques such H-1, C-13 NMR, FT-IR, UV-vis and MS spectral data. The molecular geometry and gauge including atomic orbital (GIAO) H-1 and C-13 chemical shift values of the compounds in the ground state have also been calculated using B3LYP with the 6-31G(d) basis set. The chemical shift of the optimized molecular structure is compared with the experimental chemical shift values.Pamukkale UniversityPamukkale University [2018FEBE002]The numerical calculations reported in this paper were partially performed at TUBITAK ULAKBIM, High Performance and Grid Computing Center (TRUBA resources). The study was also supported by Pamukkale University (Grant no: 2018FEBE002)