The RANLUX generator: resonances in a random walk test

Using a recently proposed directed random walk test, we systematically investigate the popular random number generator RANLUX developed by Luescher and implemented by James. We confirm the good quality of this generator with the recommended luxury level. At a smaller luxury level (for instance equal to 1) resonances are observed in the random walk test. We also find that the lagged Fibonacci and Subtract-with-Carry recipes exhibit similar failures in the random walk test. A revised analysis of the corresponding dynamical systems leads to the observation of resonances in the eigenvalues of Jacobi matrix.Comment: 18 pages with 14 figures, Essential addings in the Abstract onl

Preclinical study of the efficacy and safety of wound healing gel containing chitosan, taurine and allantoin

Objectives: To develop gel containing chitosan, taurine, allantoin, and to experimentally investigate its wound healing properties in preclinical studies on laboratory animal

Detection of rifampicin and izoniazid resistance in Mycobacterium tuberculosis strains from Samara Region (Central Russia)

Recently high rates of tuberculosis incidence and prevalence are observed in civilian and prisons sectors in Russia. One of the main reasons for high morbidity levels and ineffectiveness of treatment is wide spreading of drug resistant Mycobacterium tuberculosis strains, but accurate and comprehensive information on levels of drug resistance among strains circulating in Central Russia is unavailable. Rifampicin and izoniazid resistance detection in TB isolates from Samara (Central Russia) civilian and prison TB hospitals and dispensaries in 2000–2002 by revealing mutations in rpoB, katG and inhA genes using Macroarray technique. Methods: A total of 342 M. tuberculosis isolates were tested using Macroarray method. It is based on multiplex amplification of rpoB, katG and inhA genes fragments (with three pairs of biotin labeled primers) following by dothybridization with normal and mutant oligonucleotide probes (fragments of rpoB, katG and inhA genes in which mutations occur) immobilized on nylon membrane strips. Mycobacterial DNA was extracted by heating of cell suspensions following by chloroform extraction. Streptavidin-alkaline phosphatase color development system was used for visualization of results

Outer Labour Migration (as exemplified by the Ukraine)

The author focuses his attention on the peculiar features of migration processes in the modern Ukranian society. The article analyzes trends as well as economic, socio-cultural and social-psychological risks of outer labour migration. The author emphasizes both quantitative and qualitative consequences of labour migration including intellectual migration

New approaches to prevention of NSAID-gastropathy

At present, the issue of gastric mucosal damage, induced by the use of nonsteroidal anti-inflammatory drugs, remains unresolved. The development of new methods of prevention of NSAID-gastropathies with oral coursework use of taurine and procaine, as well as the study of cellular mechanisms of the damaging effect of diclofenac sodium and Ketorolac tromethamine. The methodological approach was based on a range of theoretical, pharmacological, histological, statistical, biophysical method

New approaches to prevention of NSAID-gastropathy

At present, the issue of gastric mucosal damage, induced by the use of nonsteroidal anti-inflammatory drugs, remains unresolved. The development of new methods of prevention of NSAID-gastropathies with oral coursework use of taurine and procaine, as well as the study of cellular mechanisms of the damaging effect of diclofenac sodium and Ketorolac tromethamine. The methodological approach was based on a range of theoretical, pharmacological, histological, statistical, biophysical method