Hookah Health Hazards

Ramen noodles, cramming for tests, hooking up and boozing. Ahhh, the life of a college student. None of these activities scream “healthy.” We often don’t think about what we’re putting into our bodies. Young adults have a reputation of being a very unhealthy demographic, and some students add to that by smoking tobacco in different forms. Hookah has become a popular tobacco choice throughout the United States in recent years, and particularly in Ames with the opening of the Chicha Shack in 2004

By myself but not alone:Agency, creativity, and extended musical historicity

In this paper we offer a preliminary framework that highlights the relational nature of solo music-making, and its associated capacity to influence the constellation of habits and experiences one develops through acts of musicking. To do so, we introduce the notion of extended musical historicity and suggest that when novice and expert performers engage in individual musical practices, they often rely on an extended sense of agency which permeates their musical experience and shapes their creative outcomes. To support this view, we report on an exploratory, qualitative study conducted with novice and expert music performers. This was designed to elicit a range of responses, beliefs, experiences and meanings concerning the main categories of agency and creativity. Our data provide rich descriptions of solitary musical practices by both novice and expert performers, and reveal ways in which these experiences involve social contingencies that appear to generate or transform creative musical activity. We argue that recognition of the interactive components of individual musicking may shed new light on the cognition of solo and joint music performance, and should inspire the development of novel conceptual and empirical tools for future research and theory

Investigating Dandy-Walker Syndrome: Integrating Conversation Analysis and Reading Eye-Movements

This paper presents an investigation into the reading eye movements of a 12-year-old child with Dandy-Walker syndrome and late onset stuttering. Conversation Analysis, video analysis, and Eye Movement Miscue Analysi

Environmental health conditions in protracted displacement: a systematic scoping review

Adequate environmental health services are critical for human rights, health, and development, especially in the context of forced displacement. There are more than 70 million forcibly displaced persons worldwide, most in protracted situations, having been displaced for more than two years. Some live in camps or informal settlements, but most live in urban areas. Environmental health services are important in the transition from emergency re- sponse to sustainable development in these settings, but evidence on environmental health in displaced popula- tions is disparate and of variable quality. We conducted a systematic scoping review of environmental conditions, exposures, and outcomes in protracted displacement settings; obstacles to improvement in environmental health services; and recommendations made for improvement. We included 213 publications from peer- reviewed and grey literature databases. Data were extracted on environmental health topics including water, sanitation, hygiene, overcrowding, waste management, energy supply, vector control, menstrual hygiene, air quality, and food safety. Most studies present data from low- and lower-middle income countries. Northern Africa and Western Asia and Sub-Saharan Africa are the most-represented regions. There is substantial evidence on water, sanitation, and crowding, but few studies report findings on other environmental health topics. Water-related disease, parasites, and respiratory infections are frequently cited and studies report that services often fail to meet international standards for humanitarian response. The most frequent obstacles and recommendations are institutional, political, or implementation-related, but few studies provide concrete recommendations for im- provement. Our review compiles and characterizes the research on environmental health in protracted displace- ment. We recommend including displaced populations in international environmental health policy and monitoring initiatives, and bridging from humanitarian response to sustainable development by preparing for long-term displacement from the early stages of a crisis

Seasonality, water use and community management of water systems in rural settings: Qualitative evidence from Ghana, Kenya, and Zambia

The sustainability of rural, community-managed water systems in sub-Saharan Africa depends in part on the ability of local water committees to repair breakdowns and carry out the operation and maintenance (O&M) of the system. Much of sub-Saharan Africa has two distinct seasons that affect the availability of water sources and how people use water. Little is known about how seasonality affects water system management. This qualitative study is based on 320 interviews and focus group discussions and examines the effects of season on community water use and management in Ghana, Kenya and Zambia. Participants revealed that seasonality affects water availability, water system breakdowns, resource mobilization, committee activity, and external support availability. In the rainy season, participants typically reported spending less time and money on water collection because rainwater harvesting and seasonal streams, ponds, wells and reservoirs are available. In the dry season, people used improved groundwater sources more often and spent more money and time collecting water. Although seasonal changes in household water demand and use have been examined previously, our data suggest that seasonality also influences community management through differential water system use, system breakdowns and management characteristics. We found that water committees generally have less money, time and access to external support during the rainy season, making them less able to carry out O&M. Our results suggest that community engagement should take place over a long period of time so that seasonal patterns in management can be understood and incorporated into water committee training. External support actors should make a more targeted effort to understand the cultural and economic patterns in a community in order to train committees with appropriate management strategies

Androgen receptor agonists increase lean mass, improve cardiopulmonary functions and extend survival in preclinical models of Duchenne muscular dystrophy

© The Author 2017. Duchenne muscular dystrophy (DMD) is a neuromuscular disease that predominantly affects boys as a result of mutation(s) in the dystrophin gene. DMD is characterized by musculoskeletal and cardiopulmonary complications, resulting in shorter life-span. Boys afflicted by DMD typically exhibit symptoms within 3-5 years of age and declining physical functions before attaining puberty. We hypothesized that rapidly deteriorating health of pre-pubertal boys with DMD could be due to diminished anabolic actions of androgens in muscle, and that intervention with an androgen receptor (AR) agonist will reverse musculoskeletal complications and extend survival. While castration of dystrophin and utrophin double mutant (mdx-dm) mice to mimic pre-pubertal nadir androgen condition resulted in premature death, maintenance of androgen levels extended the survival. Non-steroidal selective-AR modulator, GTx-026, which selectively builds muscle and bone was tested in X-linked muscular dystrophy mice (mdx). GTx-026 significantly increased body weight, lean mass and grip strength by 60-80% over vehicle-treated mdx mice. While vehicle-treated castrated mdx mice exhibited cardiopulmonary impairment and fibrosis of heart and lungs, GTx-026 returned cardiopulmonary function and intensity of fibrosis to healthy control levels. GTx-026 elicits its musculoskeletal effects through pathways that are distinct from dystrophin-regulated pathways, making AR agonists ideal candidates for combination approaches. While castration of mdx-dm mice resulted in weaker muscle and shorter survival, GTx-026 treatment increased the muscle mass, function and survival, indicating that androgens are important for extended survival. These preclinical results support the importance of androgens and the need for intervention with AR agonists to treat DMD-affected boys

Eleven Show Card

Show card for Eleven. May 6 - August 20, 2006.https://digitalcommons.udallas.edu/eleven_05-06/1000/thumbnail.jp

VERTICO VI: Cold-gas asymmetries in Virgo cluster galaxies

We analyze cold-gas distributions in Virgo cluster galaxies using resolved CO(2-1) (tracing molecular hydrogen, H2) and HI observations from the Virgo Environment Traced In CO (VERTICO) and the VLA Imaging of Virgo in Atomic Gas (VIVA) surveys. From a theoretical perspective, it is expected that environmental processes in clusters will have a stronger influence on diffuse atomic gas compared to the relatively dense molecular gas component, and that these environmental perturbations can compress the cold interstellar medium in cluster galaxies leading to elevated star formation. In this work we observationally test these predictions for star-forming satellite galaxies within the Virgo cluster. We divide our Virgo galaxy sample into HI-normal, HI-tailed, and HI-truncated classes and show, unsurprisingly, that the HI-tailed galaxies have the largest quantitative HI asymmetries. We also compare to a control sample of non-cluster galaxies and find that Virgo galaxies, on average, have HI asymmetries that are 40 +/- 10 per cent larger than the control. There is less separation between control, HI-normal, HI-tailed, and HI-truncated galaxies in terms of H2 asymmetries, and on average, Virgo galaxies have H2 asymmetries that are only marginally (20 +/- 10 per cent) larger than the control sample. We find a weak correlation between HI and H2 asymmetries over our entire sample, but a stronger correlation for those specific galaxies being strongly impacted by environmental perturbations. Finally, we divide the discs of the HI-tailed Virgo galaxies into a leading half and trailing half according to the observed tail direction. We find evidence for excess molecular gas mass on the leading halves of the disc. This excess molecular gas on the leading half is accompanied by an excess in star formation rate such that the depletion time is, on average, unchanged.Comment: 15 pages, 8 figures, 1 table, accepted for publication in A&

Acetate Promotes T Cell Effector Function during Glucose Restriction.

Competition for nutrients like glucose can metabolically restrict T cells and contribute to their hyporesponsiveness during cancer. Metabolic adaptation to the surrounding microenvironment is therefore key for maintaining appropriate cell function. For instance, cancer cells use acetate as a substrate alternative to glucose to fuel metabolism and growth. Here, we show that acetate rescues effector function in glucose-restricted CD8+ T cells. Mechanistically, acetate promotes histone acetylation and chromatin accessibility and enhances IFN-γ gene transcription and cytokine production in an acetyl-CoA synthetase (ACSS)-dependent manner. Ex vivo acetate treatment increases IFN-γ production by exhausted T cells, whereas reducing ACSS expression in T cells impairs IFN-γ production by tumor-infiltrating lymphocytes and tumor clearance. Thus, hyporesponsive T cells can be epigenetically remodeled and reactivated by acetate, suggesting that pathways regulating the use of substrates alternative to glucose could be therapeutically targeted to promote T cell function during cancer