Methodological approaches to the diagnosis and forecast of the long-wave fluctuations in the economy

© 2016,Econjournals. All rights reserved.Evolutionary development of economic systems demonstrates the cyclical nature in time. In such a case these cyclical fluctuations comprise all facets of economic relations,starting from the production sector and ending the sphere of services,focused on ensuring the interaction effectiveness of economic relations. As the modern world experience shows the cyclical dynamics has a number of its individual features depending on a wide range of factors,such as the type of economic system (planned or market),market type,forms and methods of state or other effects on the regulation of cycles within smoothing process,etc. The knowledge of these factors,the nature of their origin and the impact on the long-term cyclical fluctuations is not a trivial matter and requires a comprehensive system analysis,based on a synthesis and a dialectic of the established approaches

Formación de la interacción social competencia de futuros especialistas del ámbito gerencial

Trends in the economic situation development in the Russian Federation determine the basic requirements for graduates of Russian universities in the direction of “management” training, whose professional competence depends directly on the level of mastering communication skills and social interaction skills. The social interaction competence for managers is the key one in the formation of professional competencies and affects the decision-making of many professional tasks. The social interaction competence plays an important role in the management personnel training because they have a need for constant interaction with people, staff and clients. Lack of social interaction competence can lead to failures in professional activities. Thus, the bachelor of management should have not only knowledge in the professional sphere, but also be able to interact with various specialists, clients, and partners, carrying out high-level social communication that can affect effectively the result of professional activity.Las tendencias en el desarrollo de la situación económica en la Federación de Rusia determinan los requisitos básicos para los graduados de las universidades rusas en la dirección de la formación de “gestión”, cuya competencia profesional depende directamente del nivel de dominio de las habilidades de comunicación y de interacción social. La competencia de interacción social para los gerentes es la clave en la formación de competencias profesionales y afecta la toma de decisiones de muchas tareas profesionales. La competencia de interacción social juega un papel importante en la capacitación del personal de gestión, ya que tienen una necesidad de interacción constante con las personas, el personal y los clientes. La falta de competencia de interacción social puede conducir a fallas en las actividades profesionales. Por lo tanto, el licenciado en administración debe tener no solo conocimiento en el ámbito profesional, sino también poder interactuar con varios especialistas, clientes y socios, llevando a cabo una comunicación social de alto nivel que pueda afectar de manera efectiva el resultado de la actividad profesional

Management of environmental load factors on the territory of the socio-economic well-Being of the population

The article provides insights into the methodological approaches to the complex evaluation of the people quality of life associated with the analysis of the interaction between social and economic well-being and environmental quality. The study offers the results of the mathematical calculations which demonstrate the relation between the level of well-being of the population and the level of the ecological environment's development based on the cases of the municipal areas of the Republic Tatarstan, Russia. The key policy recommendations aiming at the improvement of the people quality of life vis-à-vis the features of the municipal development are postulated

The experimental cascade curves of EAS at E sub 0 10(17) eV obtained by the method of detection of Cherenkov pulse shape

The individual cascade curves of EAS with E sub 0 10 to the 17th power eV/I to 3/ were studied by detection of EAS Cherenkov light pulses. The scintillators located at the center of the Yakutsk EAS array within a 500-m radius circle were used to select the showers and to determine the main EAS parameters. The individual cascade curves N(t) were obtained using the EAS Cherenkov light pulses satisfying the following requirements: (1) the signal-to-noise ratio fm/delta sub n 15, (2) the EAS axis-detector distance tau sub 350 m, (3) the zenith angle theta 30 deg, (4) the probability for EAS to be detected by scintillators W 0.8. Condition (1) arises from the desire to reduce the amplitude distortion of Cherenkov pulses due to noise and determines the range of EAS sizes, N(t). The resolution times of the Cherenkov pulse shape detectors are tau sub 0 approx. 23 ns which results in distortion of a pulse during the process of the detection. The distortion of pulses due to the finiteness of tau sub 0 value was estimated. It is shown that the rise time of pulse becomes greater as tau sub 0.5/tau sub 0 ratio decreases

STUDY OF ADHESION ACTIVITY GEL COMPOSITIONS TRIMECAINE

Local anesthesia is an integral component of medical procedures in today's children's dental practice. Enumeration of intraoral drugs containing anesthetics, for pediatric dentistry is extremely insufficient. Urgent is the development of children and of the dental gel containing trimekain, for application anesthesia. The purpose of this study was to study the adhesive properties of comparative gel compositions containing various combinations and trimekain potential of shaping. The studies revealed gel compositions with excellent adhesion characteristics, which can be recommended for further screening on the creation of children's dental gel trimecaine

Regulation of p27Kip1 Protein Levels Contributes to Mitogenic Effects of the RET/PTC Kinase in Thyroid Carcinoma Cells

Abstract We show that treatment of a panel of thyroid carcinoma cell lines naturally harboring the RET/PTC1 oncogene, with the RET kinase inhibitors PP1 and ZD6474, results in reversible G1 arrest. This is accompanied by interruption of Shc and mitogen-activated protein kinase (MAPK) phosphorylation, reduced levels of G1 cyclins, and increased levels of the cyclin-dependent kinase inhibitor p27Kip1 because of a reduced protein turnover. MAP/extracellular signal-regulated kinase 1/2 inhibition by U0126 caused G1 cyclins down-regulation and p27Kip1 up-regulation as well. Forced expression of RET/PTC in normal thyroid follicular cells caused a MAPK- and proteasome-dependent down-regulation of p27Kip1. Reduction of p27Kip1 protein levels by antisense oligonucleotides abrogated the G1 arrest induced by RET/PTC blockade. Therefore, in thyroid cancer, RET/PTC-mediated MAPK activation contributes to p27Kip1 deregulation. This pathway is implicated in cell cycle progression and in response to small molecule kinase inhibitors

Экономическое развитие стран латиноамериканской ассоциации интеграции: тенденции и перспективы

Relevance. Catch-up countries are at a disadvantage in the world economy and are forced to fight for world market share. For this purpose, they form political and economic alliances and associations designed to counter the aggressive policies of the developed countries. All this applies fully to countries that are members of the Latin American Integration Association (LAIA). In our opinion, the assessment of the position of the participating countries on the geopolitical map of the world deserves special attention.Purpose of the study consists in the formation of an author’s methodology for studying the economic development of countries that are members of the Latin American Integration Association and building a forecast in the medium term on the basis of statistical tools. Materials and methods. The study used general research methods, such as analysis, comparisons, historical, as well as mathematical and statistical, in particular tabular and graphical, descriptive statistics and elements of correlation-regression analysis. A set of these methods and algorithms made it possible to identify the patterns that have developed at the moment in the economies of the Latin American Integration Association countries, assess their positions regarding world leaders, and also build short-term development forecasts.Results. With considerable resources, the countries of the Latin American Integration Association have not been able to significantly increase the share of world GDP during the existence of the association, which throughout the period does not exceed 5%. Within the association, there is a considerable differentiation. So the dominant positions are occupied by Brazil, Mexico, Argentina, while the positions of outsiders, by a significant margin, are occupied by Uruguay, Ecuador and Cuba. The structure of the economies of the association countries is largely different from the developed countries: the former are dominated by manufacturing, while the latter are dominated by services. A causal analysis of the impact of industries on GDP per capita, conducted in two time slices in 1990 and 2019, showed that during this time the countries that are members of the association have not been able to reformat the structure of their economies, which does not allow successful competition with developed countries. An element of the scientific novelty of the study is the formation of a theoretical and methodological approach to the study of the economic development of the geopolitical structure, which is the Latin American Integration Association, as well as the testing of this approach based on the actual data of international organizations.Conclusion. The testing of the author’s methodology aimed at studying the economic development of LAIA member countries allows us to argue about the operability of the algorithm, which made it possible to establish the low efficiency of the integration policy of Latin American countries, which, despite the significant level of national wealth, does not allow us to form a trend towards economic growth, a decrease in dependence on the export of natural capital, and an increase in the standard of living of the population. Some research findings from the study can be used in training activities for the disciplines of “Macroeconomics”, “International Statistics”, “Geoeconomics”, “Econometrics”, as well as in the analysis of the joint dynamics of political and economic communities, associations and groups. In subsequent publications, an in-depth analysis of the causes of the economic decline in each member country of the association will be carried out, dominant factors affecting growth and GDP decline will be identified.Актуальность. Страны догоняющего развития занимают невыгодные позиции в мировой экономике и вынуждены бороться за долю мирового рынка. Для этого они образуют политико-экономические союзы и ассоциации, призванные противостоять агрессивной политике развитых стран. Все это в полной мере относится к странам, входящим в Латиноамериканскую ассоциацию интеграции. По нашему мнению, оценка позиции стран-участниц на геополитической карте мира заслуживает отдельного внимания.Цель исследования заключается в формировании авторской методики изучения экономического развития стран, входящих в Латиноамериканскую ассоциацию интеграции и построение прогноза в среднесрочной перспективе на основе статистического инструментария.Материалы и методы. В рамках проведенного исследования были использованы общенаучные методы исследования, такие как анализ, сравнения, исторический, а также математико-статистические, в частности табличный и графический, дескриптивные статистики и элементы корреляционно-регрессионного анализа. Набор указанных методов и алгоритмов позволил выявить закономерности, сложившиеся на текущий момент в экономике стран Латиноамериканской ассоциации интеграции, оценить их позиции относительно мировых лидеров, а также построить прогнозы развития на краткосрочную перспективу.Результаты. Обладая значительными ресурсами, страны Латиноамериканской ассоциации интеграции за период существования ассоциации не смогли значительно увеличить долю в мировом ВВП, которая на протяжении всего периода не превышает 5%. Внутри совокупности стран ассоциации наблюдается значительная дифференциация. Так доминирующие позиции занимают Бразилия, Мексика, Аргентина, тогда как позиции аутсайдеров, со значительным отрывом, занимают Уругвай, Эквадор и Куба. Структура экономики стран ассоциации в значительной степени отличается от развитых стран: у первых доминирует обрабатывающая промышленность, тогда как у вторых, виды деятельности сферы услуг. Причинно-следственный анализ влияния отраслей на ВВП на душу населения, проведенный в двух временных срезах 1990 г. и 2019 г., показал, что за данное время страны, входящие в ассоциацию, не смогли переформатировать структуру своей экономии, что не позволяет успешно конкурировать с развитыми странами. Элементом научной новизны проведенного исследования является формирование теоретико-методологического подхода к изучению экономического развития геополитической структуры, которой является Латиноамериканской ассоциации интеграции, а также апробация данного подхода на основе фактических данных международных организаций.Заключение. Апробация авторской методики, направленной на изучение экономического развития стран-членов ЛАИ, позволяет утверждать о работоспособности алгоритма, который позволил установить низкую эффективность интеграционной политики латиноамериканских стран, что несмотря на значительный уровень национального богатства не позволяет сформировать тренд на рост экономики, снижение зависимость от экспорта природного капитала, и повышения уровня жизни населения. Некоторые научные наработки, полученные в ходе выполнения исследования, могут быть использованы в учебной деятельности для проведения занятий по дисциплинам «макроэкономика», «международная статистика», «геоэкономика», «эконометрика», а также при проведении анализа совместной динамики политико-экономических содружеств, ассоциаций и групп. В последующих публикациях будет проведен углубленный анализ причин экономического спада в каждой стране-участнице ассоциации, выделены доминанты, влияющие на рост и снижение ВВП

The Cancer Genomics Resource List 2014

Context.— Genomic sequencing for cancer is offered by commercial for-profit laboratories, independent laboratory networks, and laboratories in academic medical centers and integrated health networks. The variability among the tests has created a complex, confusing environment. Objective.— To address the complexity, the Personalized Health Care (PHC) Committee of the College of American Pathologists proposed the development of a cancer genomics resource list (CGRL). The goal of this resource was to assist the laboratory pathology and clinical oncology communities. Design.— The PHC Committee established a working group in 2012 to address this goal. The group consisted of site-specific experts in cancer genetic sequencing. The group identified current next-generation sequencing (NGS)–based cancer tests and compiled them into a usable resource. The genes were annotated by the working group. The annotation process drew on published knowledge, including public databases and the medical literature. Results.— The compiled list includes NGS panels offered by 19 laboratories or vendors, accompanied by annotations. The list has 611 different genes for which NGS-based mutation testing is offered. Surprisingly, of these 611 genes, 0 genes were listed in every panel, 43 genes were listed in 4 panels, and 54 genes were listed in 3 panels. In addition, tests for 393 genes were offered by only 1 or 2 institutions. Table 1 provides an example of gene mutations offered for breast cancer genomic testing with the annotation as it appears in the CGRL 2014. Conclusions.— The final product, referred to as the Cancer Genomics Resource List 2014, is available as supplemental digital content