Fabrication, characterization and degradation of electrospun poly(?-caprolactone) infused with selenium nanoparticles

Polycaprolactone (pcl) is widely used in the fabrication of nanofibers through electrospinning technique. Pcl is a biodegradable material that is economical, simple and can be scaled up for industrial production. In this study, pcl was infused with selenium nanoparticles (senps) via electrospinning to fabricate pcl-senps nanofiber. Field emission scanning electron microscopy (fesem) images of the samples revealed ‘aligned fibers’ was successfully fabricated with a diameter size of less than 350 nm and an average diameter of 185 nm. The presence of se in the nanofiber was confirmed by energy dispersive x-ray analysis (edx) and raman spectra. Based on the x-ray diffraction (xrd) pattern, the structure of pcl did not change and remains in the pcl-senps nanofibers. The functional groups of pcl, as indicated by infrared (ir) spectra remained the same after senps infusion. These results demonstrated that the physical and chemical properties of pcl nanofibers were not affected by the infusion of senps. In addition, the hydrophobicity of the pcl decreased slightly in the presence of senps. The first month after degradation, disorganized and fibrous fibers of pcl-senps nanofiber were observed followed by the formation of large fiber clumps as degradation time increased. An agglomerated senps made pcl-senps nanofiber pores looser and easier to be hydrolyzed after 4 months of degradation. The sticky surface of pcl-senps nanofiber shows acceleration in the hydrolysis process after 24th weeks of degradation. The presence of senps enhanced the degradation behavior as well as reducing the degradation time to break into pieces, starting after 6 months of degradation. The ‘aligned’ pcl-senps nanofiber, which can mimic the natural tissue extracellular matrix (ecm) morphology, can potentially be used in biomedical applications such as tissue engineering, wound dressing, biomedicine, sensor and filtration application

Aerodynamic prediction of helicopter rotor in forward flight using blade element theory

In this study, the helicopter blade in forward-flight condition was investigated. The blade element theory (BET) was used throughout this analysis to investigate the angle of attack variations at the blade cross sections, lift distribution along the blade and effects of increasing helicopter speed. Prouty's helicopter data was used to validate the analysis results. In this analysis, the helicopter blade was divided into 50 equally spaced elements and the azimuth ψ was set at 7.2° for each movement of the blade. The helicopter speed of 80 m/s was considered. The analysis revealed that the computation results were in good agreement with Prouty's diagram. Furthermore, it was also evident that in the case of a helicopter in forward-flight condition, the blade at retreating side was generally at low angle of attack and experienced low lift, in contrast to the blade at advancing side. The increment of the helicopter speed affected the lift distribution along the blade. The reverse flow area was widened two times from that given by the original Prouty's diagram. In addition, it was proven that each helicopter has its own speed limit called velocity never exceed (VNE). It was also shown that BET is important in conducting the analysis to modify the helicopter blade design for the aerodynamic characteristics' improvement as well as stability and general performance enhancement for the helicopter

Implantable slot antenna with substrate integrated waveguide for biomedical applications

This work presents a new design of capsule slot antenna with substrate integrated waveguide (SIW) for wireless body area networks (WBANs) operating at the range of (2.5-4 GHz) which is located in the body area networks (BAN) standard in IEEE802.15.6. The proposed antenna was designed for WBANs. The substrate is assumed to be from Rogers 5880 with relative permittivity of 2.2, and thickness of 0.787 mm. The ground and the patch are created from annealed copper while the capsule is assumed to be a plastic material of medical grade polycarbonate. The antenna designed and summited using computer simulation technology (CST) software. A CST voxel model was used to study the performance of SIW capsule antenna and the ability of the band (2.5-4 GHz). Results indicated a wide bandwidth of 1.5 GHz between the range of (2.5-4) GHz at 3.3 GHz as center frequency, with return loss with more than -24.52 dB, a gain of -18.2 dB, voltage standing wave ratio (VSWR) of 1.17, and front-to-back ratio (FBR) of 10.07 dB. Through simulation, all considerable parameters associated with the proposed antenna including return loss, bandwidth, operating frequency, VSWR less than 2, radiation pattern were examined. Regarding size, gain, and frequency band, the proposed antenna is located with the standards of implantable medical devices

How frequent is bystander cardiopulmonary resuscitation performed in the community of Kota Bharu, Malaysia?

INTRODUCTION Bystander cardiopulmonary resuscitation (CPR) serves as a vital link to improve the chance of survival among the out-of-hospital cardiac arrest (OHA) patients. The frequency of bystander CPR in Malaysia is largely unknown. The aim of this study was to find out how frequently bystander CPR was performed among OHA patients with CPR performed at the Emergency Department (ED), Hospital Universiti Sains Malaysia (HUSM), prior to their arrival to the department. METHODS In this one-year observational study, data was collected from cases of CPR performed in ED, HUSM. In the OHA category, a subanalysis was further performed to look into the frequency and effects of bystander CPR on achieving return of spontaneous circulation and survival to hospital admission. The categorical data collected was analysed using chi-square test or Fisher-exact test. RESULTS Out of a total of 23 OHA patients that had CPR performed on arrival at the ED, HUSM, from March 2005 to March 2006, only two cases (8.7 percent) had bystander CPR performed. None of these two cases achieved return of spontaneous circulation. CONCLUSION Although this study has many limitations, it does indicate that the frequency of bystander CPR is dismally low in our community and the mere fact that bystander CPR was reported to be done does not seem to translate into a higher chance of survival to admission. The quality and effectiveness of the technique is equally important

Knowledge of Good Blood Culture Sampling Practice among Healthcare Staffs in An Emergency Department - Are We Getting It Right?

BACKGROUND Although a vital test, blood culture is often plagued with the problem of contamination and false results, especially in a chaotic emergency department setting. The objectives of this pilot study is to find out the level of understanding among healthcare staffs in emergency department, Hospital Universiti Sains Malaysia (HUSM) regarding good blood culture sampling practice. METHODS All healthcare staffs in emergency department, HUSM who consented to this study were given a set of selfadministered anonymous questionnaire to fill. RESULTS More than half (53.1%) of the 64 participants are emergency medicine residents. Majority of them (75%) have been working in the emergency medicine, HUSM for more than 2 years. More than half of them were able to answer correctly the amount of blood volume needed for culture in adult and pediatric patients. When asked what are the factors required to improve the true yield as well as to reduce the risk of culture contamination, the four commonest answers given were observing proper aseptic technique during blood sampling, donning sterile glove, proper hand scrubbing as well as ensuring the sterility of the equipments. DISCUSSION AND CONCLUSION This study suggests that there is a lack of proper knowledge of good blood culture sampling practice among our healthcare staffs in emergency department

Wind lens performance investigation at low wind speed

In this research work, we investigated a diffuser augmented wind turbine's performance or better known as a wind lens. The wind lens consists of a circular flanged diffuser and a horizontal axis wind turbine with a diameter of 0.6 m. The diffuser length to the diameter ratio is 0.226, and the flange height to diameter ratio is 0.1. The performance of the wind Lens is investigated numerically by solving the flow field using Reynolds Averaged Navier-Stokes for incompressible flow. The finding of this work shows that the flange's role is significant to the performance; also, it shows that the opening angle of the diffuser is essential if the rotation speed of the turbine is set wisely. The wind lens's output torque at an inlet speed of 5 m/s is superior to the bare turbine by 30-60%, which shows the wind lens's usefulness at low wind speed

A whole genome analyses of genetic variants in two Kelantan Malay individuals

The sequencing of two members of the Royal Kelantan Malay family genomes will provide insights on the Kelantan Malay whole genome sequences. The two Kelantan Malay genomes were analyzed for the SNP markers associated with thalassemia and Helicobacter pylori infection. Helicobacter pylori infection was reported to be low prevalence in the north-east as compared to the west coast of the Peninsular Malaysia and beta-thalassemia was known to be one of the most common inherited and genetic disorder in Malaysia.By combining SNP information from literatures, GWAS study and NCBI ClinVar, 18 unique SNPs were selected for further analysis. From these 18 SNPs, 10 SNPs came from previous study of Helicobacter pylori infection among Malay patients, 6 SNPs were from NCBI ClinVar and 2 SNPs from GWAS studies. The analysis reveals that both Royal Kelantan Malay genomes shared all the 10 SNPs identified by Maran (Single Nucleotide Polymorphims (SNPs) genotypic profiling of Malay patients with and without Helicobacter pylori infection in Kelantan, 2011) and one SNP from GWAS study. In addition, the analysis also reveals that both Royal Kelantan Malay genomes shared 3 SNP markers; HBG1 (rs1061234), HBB (rs1609812) and BCL11A (rs766432) where all three markers were associated with beta-thalassemia.Our findings suggest that the Royal Kelantan Malays carry the SNPs which are associated with protection to Helicobacter pylori infection. In addition they also carry SNPs which are associated with beta-thalassemia. These findings are in line with the findings by other researchers who conducted studies on thalassemia and Helicobacter pylori infection in the non-royal Malay population.Wan Khairunnisa Wan Juhari, Nur Aida Md Tamrin, Mohd Hanif Ridzuan Mat Daud, Hatin Wan Isa, Nurfazreen Mohd Nasir, Sathiya Maran, Nur Shafawati Abdul Rajab, Khairul Bariah Ahmad Amin Noordin, Nik Norliza Nik Hassan, Rick Tearle, Rozaimi Razali, Amir Feisal Merican and Bin Alwi Zilfali

ToyBox Malaysia Panduan Umum Guru

Konsep ToyBox Study diadaptasi daripada program ENERGY, program intervensi Cretan Health and Nutrition, manakala teks dan bahan diadaptasi daripada TigerKids. Bahan berkaitan Pinggan Sihat Malaysia digunapakai dengan izin daripada Bahagian Pemakanan, Kementerian Kesihatan Malaysia

The impact of surgical delay on resectability of colorectal cancer: An international prospective cohort study

AIM: The SARS-CoV-2 pandemic has provided a unique opportunity to explore the impact of surgical delays on cancer resectability. This study aimed to compare resectability for colorectal cancer patients undergoing delayed versus non-delayed surgery. METHODS: This was an international prospective cohort study of consecutive colorectal cancer patients with a decision for curative surgery (January-April 2020). Surgical delay was defined as an operation taking place more than 4 weeks after treatment decision, in a patient who did not receive neoadjuvant therapy. A subgroup analysis explored the effects of delay in elective patients only. The impact of longer delays was explored in a sensitivity analysis. The primary outcome was complete resection, defined as curative resection with an R0 margin. RESULTS: Overall, 5453 patients from 304 hospitals in 47 countries were included, of whom 6.6% (358/5453) did not receive their planned operation. Of the 4304 operated patients without neoadjuvant therapy, 40.5% (1744/4304) were delayed beyond 4 weeks. Delayed patients were more likely to be older, men, more comorbid, have higher body mass index and have rectal cancer and early stage disease. Delayed patients had higher unadjusted rates of complete resection (93.7% vs. 91.9%, P = 0.032) and lower rates of emergency surgery (4.5% vs. 22.5%, P < 0.001). After adjustment, delay was not associated with a lower rate of complete resection (OR 1.18, 95% CI 0.90-1.55, P = 0.224), which was consistent in elective patients only (OR 0.94, 95% CI 0.69-1.27, P = 0.672). Longer delays were not associated with poorer outcomes. CONCLUSION: One in 15 colorectal cancer patients did not receive their planned operation during the first wave of COVID-19. Surgical delay did not appear to compromise resectability, raising the hypothesis that any reduction in long-term survival attributable to delays is likely to be due to micro-metastatic disease