A Review of Functional Safety Models for Public Safety Management Systems

This paper reviews various models used for enterprise process management systems and public safety systems. These models include probabilistic functional safety models, accident models such as causal-sequential event-based models, systemic models such as failure mode and effects analysis (FMEA), reliability models, systemic models such as systems-theoretic accident model and processes (STAMP) model and cognitive models, among others. These models, along with their advantages and disadvantages, are discussed in detail. Existing public safety management systems and enterprise process management systems are also compared. Functionally safe communication systems for public safety, including those using wireless telecommunications such as LTE for Public Safety, are also discussed. In addition, this paper also explains some of the evolving legislation regarding managed energy and managed safety for both process and public management systems

Knowledge, attitude and practice of Tanta University medical students towards hepatitis B and C

Background: Egypt lies among the world’s highest prevalence rates of HCV and intermediate levels of HBV infection. The objectives of the study were detection of the knowledge, attitude and practice of Medical Students of Tanta University towards hepatitis B and C.Methods: This was a cross-sectional study, conducted in The Faculty of Medicine, Tanta University, Egypt; from 15th October 2013 to 15th of January 2014.Results: The study included 185 Students; their ages ranged between 17 to 28 years with a mean 20±1.731years. Sixty percent of students were males and 65% were urban residents. 50.8% of the participants were in the basic level of the academic study. More than half (57.85%) of the participants had sufficient knowledge, 77.3% of them had a positive attitude towards hepatitis C and B and more than two-thirds (68.1%) showed good practice. A significant association occurred between a positive attitude and good practice. Sufficient knowledge was significantly recorded among older students, females, urban residents and the clinical stage students. The most frequent sources of student information were family or friends, internet followed by TV or radio, healthcare workers, and newspapers.Conclusions: The students had reasonable knowledge, positive attitude and good practices towards B and C viral hepatitis. Areas of insufficient knowledge needed to be reinforced included some modes of transmission, complications, and treatment for B and C viral hepatitis

Enhancing Breast Cancer Prediction through Deep Learning and Comparative Analysis of Gene Expression and DNA Methylation Data using Convolutional Neural Networks

Recent advances in the production of statistics have resulted in an exponential increase in the number of facts, ushering in a whole new era dominated by very large facts. Conventional machine-learning algorithms are unable to handle the most recent aspects of huge data. This is a fact.  In order to make an accurate prognosis of breast cancer, researchers employ and evaluate three distinct computer programmes called Support Vector Machine (SVM), Random Forest (RF), and Decision Tree (DT). Within the context of huge statistics, we explore the question of how breast cancer may be predicted in this particular research. Gene expression and DNA methylation are both taken into consideration as part of the analysis (GE and DM, respectively). The purpose of the work that we are doing is to increase the capacity of the Deep Learning algorithms that are now being used for typing by applying each dataset individually and together. As a result of this decision, the platform of choice is MATLAB. In the process of breast cancer prediction, the Convolutional Neural Network (CNN) algorithm is used. Comparisons of GE, DM, and GE and DM are carried out with the help of this method. The results of the CNN algorithm are compared to those of the RF algorithm. According to findings of the experiments, the scaled system that was presented works better than the other classifiers. This is due to the fact that using the GE dataset; it acquired the best accuracy at the lowest cost

Pharmacogenetics and the Future of Perzonalized Medications

Clinical genetic testing has grown across the globe over the past 30 decades as the causative mutations for Mendelian diseases have been pointed out, especially helped in part by the recent advances in molecular technologies. Substantially, the use of up to date tests and other strategies such as diagnostic confirmation, testing prenatally, and population-based carrier screening is offered with caution and careful consideration before implementing clinically. This may facilitate the appropriate use of brand new genetic tests available. It helps clinicians to judge and prescribe drugs more wisely. Nowadays, most of the health organizations and drug safety commissions provide revisions that include pharmacogenetic information leaflets for selected drugs. However, regardless of some pharmacogenetic associations with adverse results, rest of the proposals has been proven successfully. When compared with testing for the Mendelian diseases, pharmacogenetic testing for other manifestations may have only a negligible positive predictive value, which is one rationale for underutilization. A number of other barriers remain with implementing clinical pharmacogenetics, including lack of clinical utility, professional education, and regulatory and reimbursement issues, among others. Through this review we put forward some of the challenges and barriers faced in executing a clinical pharmacogenetic test

Planetary migration in evolving planetesimals discs

In the current paper, we further improved the model for the migration of planets introduced in Del Popolo et al. (2001) and extended to time-dependent planetesimal accretion disks in Del Popolo and Eksi (2002). In the current study, the assumption of Del Popolo and Eksi (2002), that the surface density in planetesimals is proportional to that of gas, is released. In order to obtain the evolution of planetesimal density, we use a method developed in Stepinski and Valageas (1997) which is able to simultaneously follow the evolution of gas and solid particles for up to 10^7 yrs. Then, the disk model is coupled to migration model introduced in Del Popolo et al. (2001) in order to obtain the migration rate of the planet in the planetesimal. We find that the properties of solids known to exist in protoplanetary systems, together with reasonable density profiles for the disk, lead to a characteristic radius in the range 0.03-0.2 AU for the final semi-major axis of the giant planet.Comment: IJMP A in prin

Comparative analysis of maternal and neonatal outcomes between elective and emergency caesarean section at a single tertiary hospital: a retrospective COHORT study

Background: Caesarean section rates have been increasing worldwide despite it’s known complications. The aim of this study was to determine maternal and neonatal complications related to caesarean section at Sultan Qaboos University Hospital (SQUH) and to compare the outcomes between emergency and elective caesarean sections. Methods: This retrospective cohort study was conducted in the department of obstetrics and gynecology at SQUH from 1st January 2016 to 31st December 2016. This comparative study involved 300 women who underwent caesarean section, 150 in elective caesarean section group and 150 in emergency caesarean section group. Results: The mean maternal age was 29.66 (±4.96) and 33.22 (±4.63) years in the elective and emergency caesarean section groups respectively (p=001). The main risk factor for both the groups was maternal diabetes and the most common indication was previous caesarean section. Hypotension related anesthetic complication was noted more in elective caesarean section (15.3%) than in emergency caesarean section group (4.0%) with p value=0.002. Post-partum fever was seen in 12.0% of women in emergency group as compared to 4% in elective group (p=0.019). Anemia was observed in 79.2% and 65.3% in emergency and elective groups respectively (p=0.011). Respiratory distress syndrome and transient tachypnea of the newborn were the main neonatal complications in both groups. Conclusions: There was no significant difference between emergency and elective caesarean section related maternal and neonatal complications except for transient intraoperative hypotension, maternal postoperative febrile morbidity and anemia. Future prospective studies including larger sample size and multiple centers is recommended.

Possible evolution of dim radio quiet neutron star 1E 1207.4-5209 based on a B-decay model

Dim radio-quiet neutron star (DRQNS) 1E 1207.4-5209 is one of the most heavily examined isolated neutron stars. Wide absorption lines were observed in its spectrum obtained by both XMM-Newton and Chandra X-ray satellites. These absorption lines can be interpreted as a principal frequency centered at 0.7 keV and its harmonics at 1.4, 2.1 and possibly 2.8 keV. The principal line can be formed by resonant proton cyclotron scattering leading to a magnetic field which is two orders of magnitude larger than the perpendicular component of the surface dipole magnetic field (B) found from the rotation period (P) and the time rate of change in the rotation period (\.{P}) of 1E 1207.4-5209. Besides, age of the supernova remnant (SNR) G296.5+10.0 which is physically connected to 1E 1207.4-5209 is two orders of magnitude smaller than the characteristic age ($\tau$=P/2\.{P}) of the neutron star. These huge differences between the magnetic field values and the ages can be explained based on a B-decay model. If the decay is assumed to be exponential, the characteristic decay time turns out to be several thousand years which is three orders of magnitude smaller than the characteristic decay time of radio pulsars represented in an earlier work. The lack of detection of radio emission from DRQNSs and the lack of point sources and pulsar wind nebulae in most of the observed SNRs can also be partly explained by such a very rapid exponential decay. The large difference between the characteristic decay times of DRQNSs and radio pulsars must be related to the differences in the magnetic fields, equation of states and masses of these isolated neutron stars.Comment: 13 pages, 1 figur

Cyclometalated Iridium(III) Complexes with Deoxyribose Substituents

Fundamental study of enzymatic nucleoside transport suffers for lack of optical probes that can be tracked noninvasively. Nucleoside transporters are integral membrane glycoproteins that mediate the salvage of nucleosides and their passage across cell membranes. The substrate recognition site is the deoxyribose sugar, often with little distinction among nucleobases. Reported here are nucleoside analogues in which emissive, cyclometalated iridium(III) complexes are “clicked” to C-1 of deoxyribose in place of canonical nucleobases. The resulting complexes show visible luminescence at room temperature and 77 K with microsecond-length triplet lifetimes. A representative complex is crystallographically characterized. Transport and luminescence are demonstrated in cultured human carcinoma (KB3-1) cells

Cyclometalated Iridium(III) Complexes with Deoxyribose Substituents

Fundamental study of enzymatic nucleoside transport suffers for lack of optical probes that can be tracked noninvasively. Nucleoside transporters are integral membrane glycoproteins that mediate the salvage of nucleosides and their passage across cell membranes. The substrate recognition site is the deoxyribose sugar, often with little distinction among nucleobases. Reported here are nucleoside analogues in which emissive, cyclometalated iridium(III) complexes are “clicked” to C-1 of deoxyribose in place of canonical nucleobases. The resulting complexes show visible luminescence at room temperature and 77 K with microsecond-length triplet lifetimes. A representative complex is crystallographically characterized. Transport and luminescence are demonstrated in cultured human carcinoma (KB3-1) cells

Extremely Low-Frequency Magnetic Field Enhances the Therapeutic Efficacy of Low-Dose Cisplatin in the Treatment of Ehrlich Carcinoma

e present study examines the therapeutic efficacy of the administration of low-dose cisplatin (cis) followed by exposure to extremely low-frequency magnetic �eld (ELF-MF), with an average intensity of 10 mT, on Ehrlich carcinoma in vivo. e cytotoxic and genotoxic actions of this combination were studied using comet assay, mitotic index (MI), and the induction of micronucleus (MN). Moreover, the inhibition of tumor growth was also measured. Treatment with cisplatin and ELF-MF (group A) increased the number of damaged cells by 54% compared with 41% for mice treated with cisplatin alone (group B), 20% for mice treated by exposure to ELF-MF (group C), and 9% for the control group (group D). Also the mitotic index decreased signi�cantly for all treated groups ( ). e decrement percent for the treated groups (A, B, and C) were 70%,65%, and 22%, respectively, compared with the control group (D). Additionally, the rate of tumor growth at day 12 was suppressed signi�cantly ( ) for groups A, B, and C with respect to group (D). ese results suggest that ELF-MF enhanced the cytotoxic activity of cisplatin and potentiate the bene�t of using a combination of low-dose cisplatin and ELF-MF in the treatment of Ehrlich carcinoma