e present study examines the therapeutic efficacy of the administration of low-dose cisplatin (cis) followed by exposure to extremely low-frequency magnetic �eld (ELF-MF), with an average intensity of 10 mT, on Ehrlich carcinoma in vivo. e cytotoxic and genotoxic actions of this combination were studied using comet assay, mitotic index (MI), and the induction of micronucleus (MN). Moreover, the inhibition of tumor growth was also measured. Treatment with cisplatin and ELF-MF (group A) increased the number of damaged cells by 54% compared with 41% for mice treated with cisplatin alone (group B), 20% for mice treated by exposure to ELF-MF (group C), and 9% for the control group (group D). Also the mitotic index decreased signi�cantly for all treated groups ( ). e decrement percent for the treated groups (A, B, and C) were 70%,65%, and 22%, respectively, compared with the control group (D). Additionally, the rate of tumor growth at day 12 was suppressed signi�cantly ( ) for groups A, B, and C with respect to group (D). ese results suggest that ELF-MF enhanced the cytotoxic activity of cisplatin and potentiate the bene�t of using a combination of low-dose cisplatin and ELF-MF in the treatment of Ehrlich carcinoma
