Agha Shahid Ali And His Penetrating Voice Echoing Unheard Kashmir

Agha Shahid Ali was born in New Delhi on Feb 4, 1949.He grew up in Kashmir, returned to New Delhi to complete his MA in DU.He authored several collections of poetry:Bone Seculpture, In Memory of Begum Akhtar and Other Poems, The Half- Inch Himalayas ,A Walk Through the Yellow Pages, A Nostalgist's  Map of America, The Beloved Witness : Selected Poems ,The Country Without a  Post office etc. Like many of the greatest contemporary writers, it is not easy to define Shahid's nationality. He has a transgeographical background as a Kashmiri, Indian and American. The young Shahid went through phases of demonstrating belief in both Christianity and Hinduism and his liberal family was liberal about this. The Country Without a Post Office portrays many of the atrocities like rapes ,curfews , tortures ,imprisonments, murders ,custodial deaths by the Indian forces as a mark of retaliation to the beginning of new phase of insurgency in Kashmir in early 90's

A Feminist Approach to Kamala Das’ Poems: “An Introduction” and “The Old Playhouse.”

The Paper attempts a close reading of selected Kamala Das poems to trace their feminist contours more specifically in relation to Helene Cixous' ericture feminine

Social Entrepreneurship in Pakistan: Challenges and Prospects

Social Entrepreneurship (SE) benefits the society by helping to achieve social and economic goals. SE is receiving scholarly attention around the globe but its development is still moderate in Pakistan. Despite the growing trend, the dominant focus of scholars remains the ideological debate about the meaning and definition of SE. Such an approach inhibits the exploration of its other facets. Casting the gap in literature, this paper aims to find out the challenges and prospects that social entrepreneurs face in their journey, specifically in Pakistan. Keeping in view the emerging importance of this sector, this study discusses the findings of 14 in-depth semi-structured interviews conducted with leading social entrepreneurs, practitioners and academicians related to the field to understand the phenomenon at hand. Drawing upon the findings of the study, useful insights have been put forth as its theoretical contribution. Moreover, local and national government can benefit from the findings to enhance consciousness regarding the fourth sector of the economy, eventually augmenting the available social capital

Entrepreneurial Finance: Exploring the Drivers and Challenges Faced by Young Pakistani Entrepreneurs

Within the last decade, the popularity of entrepreneurship rose exponentially all over the world; however, research in this field within the context of developing countries is still lacking. Generally speaking, accessibility and availability of financial support is one of the most significant factors affecting an entrepreneur’s venture when it is in its initial stages. This is especially true in the case of developing countries such as Pakistan. For this reason, this study explored the drivers and challenges faced by Pakistani entrepreneurs regarding the access to and availability of financial support. Data was collected through 65 semi-structured interviews of budding Pakistani entrepreneurs until the saturation point was reached. Afterwards, the interviews were transcribed and imported to NVivo 12 plus, which was used to conduct a thematic analysis of the interviews. The major findings of the research revealed that entrepreneurs face many challenges with regards to the access and availability of financial support in Pakistan. Additionally, according to the respondents, the entrepreneurial journey in Pakistan is laden with challenges and has minimum drivers (opportunities available to the entrepreneurs). The respondents also expressed a lack of awareness and downright distrust of the government-sponsored financial support schemes.&nbsp

Computational drug designing of fungal pigments as potential aromatase inhibitors

The existing aromatase inhibitors produced unwelcome effects impose the discovery of novel drugs with privileged selectivity, a reduced amount of toxicity and humanizing potency. In this study, we illuminate the binding mode of polyketide azaphilanoid pigments monascin, ankaflavin, monascorubrin and monascorubramine isolated from Monascus fungus to the aromatase by molecular docking. The 3-dimensional structure of aromatase enzyme (PDB: 4KQ8) was obtained from the Protein Data Bank. PatchDock docking software was used to analyze structural complexes of the aromatase with monascus pigments. Comparatively, the AutoGrid model presented the most briskly constructive binding mode of monascin to aromatase. Docked energies in kcal/mol are: monascin;-13.2; monascorubramine:-12.8, monascorubrin:-12.3; ankaflavin: -10.5. These outcomes exposed these ligands could be potential drugs to treat hormone dependent breast cancer

MicroRNA Expression Profiling of Human Respiratory Epithelium Affected by Invasive Candida Infection

Invasive candidiasis is potentially life-threatening systemic fungal infection caused by Candida albicans (C. albicans). Candida enters the blood stream and disseminate throughout the body and it is often observed in hospitalized patients, immunocompromised individuals or those with chronic diseases. This infection is opportunistic and risk starts with the colonization of C. albicans on mucocutaneous surfaces and respiratory epithelium. MicroRNAs (miRNAs) are small non-coding RNAs which are involved in the regulation of virtually every cellular process. They regulate and control the levels of mRNA stability and post-transcriptional gene expression. Aberrant expression of miRNAs has been associated in many disease states, and miRNA-based therapies are in progress. In this study, we investigated possible variations of miRNA expression profiles of respiratory epithelial cells infected by invasive Candida species. For this purpose, respiratory epithelial tissues of infected individuals from hospital laboratory were accessed before their treatment. Invasive Candida infection was confirmed by isolation of Candia albicans from the blood cultures of the same infected individuals. The purity of epithelial tissues was assessed by flow cytometry (FACSCalibur cytometer; BD Biosciences, Heidelberg, Germany) using statin antibody (S-44). TaqMan quantitative real-time PCR (in a TaqMan Low Density Array format) was used for miRNA expression profiling. MiRNAs investigated, the levels of expression of 55 miRNA were significantly altered in infected tissues. Some miRNAs showed dramatic increase (miR-16-1) or decrease of expression (miR-17-3p) as compared to control. Gene ontology enrichment analysis of these miRNA-targeted genes suggests that Candidal infection affect many important biological pathways. In summary, disturbance in miRNA expression levels indicated the change in cascade of pathological processes and the regulation of respiratory epithelial functions following invasive Candidal infection. These findings contribute to our understanding of host cell response to Candidal systemic infections

Imidazole and its derivatives as potential candidates for drug development

Imidazole and its derivatives are the pharmacological significant scaffolds with the broad spectrum of activities can be synthesized in the laboratory in the single step by the action of the catalyst. The current review summarizes the role of the imidazole and its derivatives during the last decade (2005-2014) for the treatment of many diseases. Review highlights their significant contribution towards the drug development for the treatment of some fatal diseases like HIV, cancer, tuberculosis and hepatitis C. As imidazole and its derivatives continue to play an important role for the treatment of many diseases so there is a need to trigger research in this field

Bioactivity-guided isolation of rosmarinic acid as the principle bioactive compound from the butanol extract of Isodon rugosus against pea aphid, Acyrthosiphon pisum

Aphids are agricultural pest insects that transmit viruses and cause feeding damage on a global scale. Current pest control involving the excessive use of synthetic insecticides over decades has led to multiple forms of aphid resistance to most classes of insecticides. In nature, plants produce secondary metabolites during their interaction with insects and these metabolites can act as toxicants, antifeedants, anti-oviposition agents and deterrents towards the insects. In a previous study, we demonstrated that the butanol fraction from a crude methanolic extract of an important plant species, Isodon rugosus showed strong insecticidal activity against the pea aphid, Acyrthosiphon pisum. It was however not known as which compound was responsible for such activity. To further explore this finding, current study aimed to exploit a bioactivity-guided strategy to isolate and identify the active compound in the butanol fraction of I. rugosus. As such, reversed-phase flash chromatography, acidic extraction and different spectroscopic techniques were used to isolate and identify the new compound, rosmarinic acid as the bioactive compound in I. rugosus. Insecticidal activity of rosmarinic acid was carried out using standard protocols on A. pisum. The data was analyzed using qualitative and quantitative statistical approaches. Considering that a very low concentration of this compound (LC90 = 5.4 ppm) causes significant mortality in A. pisum within 24 h, rosmarinic acid could be exploited as a potent insecticide against this important pest insect. Furthermore, I. rugosus is already used for medicinal purposes and rosmarinic acid is known to reduce genotoxic effects induced by chemicals, hence it is expected to be safer compared to the current conventional pesticides. While this study highlights the potential of I. rugosus as a possible biopesticide source against A. pisum, it also provides the basis for further exploration and development of formulations for effective field application

Bioactivity-guided isolation of rosmarinic acid as the principal bioactive compound from the butanol extract of Isodon rugosus against the pea aphid, Acyrthosiphon pisum

Aphids are agricultural pest insects that transmit viruses and cause feeding damage on a global scale. Current pest control practices involving the excessive use of synthetic insecticides over many years have resulted in aphid resistance to a number of pesticides. In nature, plants produce secondary metabolites during their interaction with insects and these metabolites can act as toxicants, antifeedants, anti-oviposition agents and deterrents towards the insects. In a previous study, we demonstrated that the butanol fraction from a crude methanolic extract of an important plant species, Isodon rugosus showed strong insecticidal activity against the pea aphid, Acyrthosiphon pisum. To further explore this finding, the current study aimed to exploit a bioactivity-guided strategy to isolate and identify the active compound in the butanol fraction of I. rugosus. As such, reversed-phase flash chromatography, acidic extraction and different spectroscopic techniques were used to isolate and identify the new compound, rosmarinic acid, as the bioactive compound in I. rugosus. Insecticidal potential of rosmarinic acid against A. pisum was evaluated using standard protocols and the data obtained was analyzed using qualitative and quantitative statistical approaches. Considering that a very low concentration of this compound (LC90 = 5.4 ppm) causes significant mortality in A. pisum within 24 h, rosmarinic acid could be exploited as a potent insecticide against this important pest insect. Furthermore, I. rugosus is already used for medicinal purposes and rosmarinic acid is known to reduce genotoxic effects induced by chemicals, hence it is expected to be safer compared to the current conventional pesticides. While this study highlights the potential of I. rugosus as a possible biopesticide source against A. pisum, it also provides the basis for further exploration and development of formulations for effective field application