388 research outputs found
Synthesis, Structure of Nitrogen-Containing Phosphinogold(I) Ferrocenes. In vitro Activity against Bladder and Colon Carcinoma Cell Lines
The gold salt [(tht)AuCl] was reacted with [1-N,N-dimethylaminométhyl-2-diphenylphosphino]ferrocene (1) forming the bimetallic derivative 4. The reaction of methyl iodide
and tetramethylammonium bromide on the chloride 4 produced the ammonium salt 5 and the
bromide 6 respectively. New aminophosphines 2 and 3, which represent two of the rare
phosphorylated metallocenes containing P(III)-N bond have also been coordinated to gold(I) to
form 7 and 8. The presence of the ethoxy group in 7 provides evidence for the lability of one
nitrogen-phosphorus bond. The X-ray structure of compounds 4 and 7 have been established.
Both crystallize in space group P21/c, monoclinic, with a = 11.095(2) Å, b = 12.030(3) Å, c =
17.763(4) Å, β= 94.02(2)∘, Z = 4 for 4 and a = 14.863(3) Å, b = 8.036(5)Å, c = 18.062(5)Å, β =101.64(1)°, Z = 4 for 7. 197Au Mössbauer data are in good agreement with those for other linear P-Au-Cl containing complexes. The compounds were evaluated for in vitro anti-tumour activity
against two human tumours. Differential cytotoxicity was observed with activity comparable to
cisplatin, with the exception of one compound which was significantly more cytotoxic
Trichlorido(tetrahydrofuran){(1,2,3,3a,7a-η)-1-[2-(1-trimethylsilyl-1H-imidazol-2-yl-κN 3)-1-methylpropyl]indenyl}zirconium(IV)
The title compound, [ZrCl3(C19H25N2Si)(C4H8O)], was prepared from bis(N,N-dimethylamido-κN)(2-{2-[(1,2,3,3a,7a-η)-indenyl]-2-methylpropyl}-1H-imidazolido-κN
1)zirconium(IV) [(C16H16N2)Zr(NMe2)] by reaction with excess Me3SiCl in tetrahydrofuran (THF) at elevated temperature. The crystal studied contained a minor non-merohedral twin contaminant [6.3 (4)%] which was taken into account during the refinement. The coordination polyhedron of the ZrIV atom is a distorted octahedron [assuming that the five-membered ring of the indenyl group (Cp) occupies one coordination site], with the Cp group and a THF O atom at the apical positions and the three Cl and ligating N atoms at the equatorial positions. The Zr, Si and the methylene C atoms deviate noticeably from the imidazole ring plane [by −0.197 (5), −0.207 (5) and 0.119 (6) Å, respectively]. The THF ligand adopts an envelope conformation
3,5-Bis(trifluoromethyl)iodobenzene
InChI = 1S/C8H3F6I/c9-7(10,11)4-1-5(8(12,13)14)3-6(15)2-4/h1-3H
InChIKey = VDPIZIZDKPFXLI-UHFFFAOYSA-N
(reagent used as a versatile allylation or arylation component)
Physical Data: bp 59–61 °C (10 mmHg); fp 74 °C; d 1.919 g cm^(−3).
Solubility: sol DMF, acetonitrile, toluene, and most organic solvents.
Form Supplied in: pale pink liquid; commercially available.
Purification: dried over MgSO_4 and fractionally distilled under vacuum.
Handling, Storage, and Precautions: air, light, and moisture sensitive; to be handled in an inert atmosphere; stored in cool, dark, and dry conditions and away from oxidizing agents
Esterification of polyallyl alcohol and its low molecular weight analogues with hypophosphorous acid
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