Refinement Type Inference via Horn Constraint Optimization

We propose a novel method for inferring refinement types of higher-order functional programs. The main advantage of the proposed method is that it can infer maximally preferred (i.e., Pareto optimal) refinement types with respect to a user-specified preference order. The flexible optimization of refinement types enabled by the proposed method paves the way for interesting applications, such as inferring most-general characterization of inputs for which a given program satisfies (or violates) a given safety (or termination) property. Our method reduces such a type optimization problem to a Horn constraint optimization problem by using a new refinement type system that can flexibly reason about non-determinism in programs. Our method then solves the constraint optimization problem by repeatedly improving a current solution until convergence via template-based invariant generation. We have implemented a prototype inference system based on our method, and obtained promising results in preliminary experiments.Comment: 19 page

Confinement and the analytic structure of the one body propagator in Scalar QED

We investigate the behavior of the one body propagator in SQED. The self energy is calculated using three different methods: i) the simple bubble summation, ii) the Dyson-Schwinger equation, and iii) the Feynman-Schwinger represantation. The Feynman-Schwinger representation allows an {\em exact} analytical result. It is shown that, while the exact result produces a real mass pole for all couplings, the bubble sum and the Dyson-Schwinger approach in rainbow approximation leads to complex mass poles beyond a certain critical coupling. The model exhibits confinement, yet the exact solution still has one body propagators with {\it real} mass poles.Comment: 5 pages 2 figures, accepted for publication in Phys. Rev.

Study of relativistic bound states for scalar theories in Bethe-Salpeter and Dyson-Schwinger formalism

The Bethe-Salpeter equation for Wick-Cutkosky like models is solved in dressed ladder approximation. The bare vertex truncation of the Dyson-Schwinger equations for propagators is combined with the dressed ladder Bethe-Salpeter equation for the scalar S-wave bound state amplitudes. With the help of spectral representation the results are obtained directly in Minkowski space. We give a new analytic formula for the resulting equation simplifying the numerical treatment. The bare ladder approximation of Bethe-Salpeter equation is compared with the one with dressed ladder. The elastic electromagnetic form factors is calculated within the relativistic impulse approximation.Comment: 30 pages, 10 figures, accepted for publication in Phys. Rev.

Unfolding-Based Process Discovery

This paper presents a novel technique for process discovery. In contrast to the current trend, which only considers an event log for discovering a process model, we assume two additional inputs: an independence relation on the set of logged activities, and a collection of negative traces. After deriving an intermediate net unfolding from them, we perform a controlled folding giving rise to a Petri net which contains both the input log and all independence-equivalent traces arising from it. Remarkably, the derived Petri net cannot execute any trace from the negative collection. The entire chain of transformations is fully automated. A tool has been developed and experimental results are provided that witness the significance of the contribution of this paper.Comment: This is the unabridged version of a paper with the same title appearead at the proceedings of ATVA 201

Relativistic bound-state equations in three dimensions

Firstly, a systematic procedure is derived for obtaining three-dimensional bound-state equations from four-dimensional ones. Unlike ``quasi-potential approaches'' this procedure does not involve the use of delta-function constraints on the relative four-momentum. In the absence of negative-energy states, the kernels of the three-dimensional equations derived by this technique may be represented as sums of time-ordered perturbation theory diagrams. Consequently, such equations have two major advantages over quasi-potential equations: they may easily be written down in any Lorentz frame, and they include the meson-retardation effects present in the original four-dimensional equation. Secondly, a simple four-dimensional equation with the correct one-body limit is obtained by a reorganization of the generalized ladder Bethe-Salpeter kernel. Thirdly, our approach to deriving three-dimensional equations is applied to this four-dimensional equation, thus yielding a retarded interaction for use in the three-dimensional bound-state equation of Wallace and Mandelzweig. The resulting three-dimensional equation has the correct one-body limit and may be systematically improved upon. The quality of the three-dimensional equation, and our general technique for deriving such equations, is then tested by calculating bound-state properties in a scalar field theory using six different bound-state equations. It is found that equations obtained using the method espoused here approximate the wave functions obtained from their parent four-dimensional equations significantly better than the corresponding quasi-potential equations do.Comment: 28 pages, RevTeX, 6 figures attached as postscript files. Accepted for publication in Phys. Rev. C. Minor changes from original version do not affect argument or conclusion

Generation and detection of guided waves using PZT wafer Transducers

Abstract We report here the use of finite element simulation and experiments to further explore the operation of the wafer transducer. We have separately modeled the emission and detection processes. In particular, we have calculated the wave velocities and the received voltage signals due to A0 and S0 modes at an output transducer as a function of pulse center frequency. These calculations include the effects of finite pulse width, pulse dispersion, and the detailed interaction between the piezoelectric element and the transmitting medium. We show that the received signals for A0 and S0 modes have maxima near the frequencies predicted from the previously published point-force model

Role of retardation in 3-D relativistic equations

Equal-time Green's function is used to derive a three-dimensional integral equation from the Bethe-Salpeter equation. The resultant equation, in the absence of anti-particles, is identical to the use of time-ordered diagrams, and has been used within the framework of $\phi^2\sigma$ coupling to study the role of energy dependence and non-locality when the two-body potential is the sum of $\sigma$-exchange and crossed $\sigma$ exchange. The results show that non-locality and energy dependence make a substantial contribution to both the on-shell and off-shell amplitudes.Comment: 17 pages, RevTeX; 8 figures. Accepted for publication in Phys. Rev. C56 (Nov. 97

Variational Worldline Approximation for the Relativistic Two-Body Bound State in a Scalar Model

We use the worldline representation of field theory together with a variational approximation to determine the lowest bound state in the scalar Wick-Cutkosky model where two equal-mass constituents interact via the exchange of mesons. Self-energy and vertex corrections are included approximately in a consistent way as well as crossed diagrams. Only vacuum-polarization effects of the heavy particles are neglected. In a path integral description of an appropriate current-current correlator an effective, retarded action is obtained by integrating out the meson field. As in the polaron problem we employ a quadratic trial action with variational functions to describe retardation and binding effects through multiple meson exchange.The variational equations for these functions are derived, discussed qualitatively and solved numerically. We compare our results with the ones from traditional approaches based on the Bethe-Salpeter equation and find an enhanced binding contrary to some claims in the literature. For weak coupling this is worked out analytically and compared with results from effective field theories. However, the well-known instability of the model, which usually is ignored, now appears at smaller coupling constants than in the one-body case and even when self-energy and vertex corrections are turned off. This induced instability is investigated analytically and the width of the bound state above the critical coupling is estimated.Comment: 62 pages, 7 figures, FBS style, published versio

Mutation-specific reporter for optimization and enrichment of prime editing

Prime editing is a versatile genome-editing technique that shows great promise for the generation and repair of patient mutations. However, some genomic sites are difficult to edit and optimal design of prime-editing tools remains elusive. Here we present a fluorescent prime editing and enrichment reporter (fluoPEER), which can be tailored to any genomic target site. This system rapidly and faithfully ranks the efficiency of prime edit guide RNAs (pegRNAs) combined with any prime editor variant. We apply fluoPEER to instruct correction of pathogenic variants in patient cells and find that plasmid editing enriches for genomic editing up to 3-fold compared to conventional enrichment strategies. DNA repair and cell cycle-related genes are enriched in the transcriptome of edited cells. Stalling cells in the G1/S boundary increases prime editing efficiency up to 30%. Together, our results show that fluoPEER can be employed for rapid and efficient correction of patient cells, selection of gene-edited cells, and elucidation of cellular mechanisms needed for successful prime editing

The Nuclear Yukawa Model on a Lattice

We present the results of the quantum field theory approach to nuclear Yukawa model obtained by standard lattice techniques. We have considered the simplest case of two identical fermions interacting via a scalar meson exchange. Calculations have been performed using Wilson fermions in the quenched approximation. We found the existence of a critical coupling constant above which the model cannot be numerically solved. The range of the accessible coupling constants is below the threshold value for producing two-body bound states. Two-body scattering lengths have been obtained and compared to the non relativistic results.Comment: 15 page