Circulating Antibody-Secreting Cells and Salivary Antibodies Induced by the Capsular Polysaccharide of Streptococcus Pneumoniae : after Parenteral Immunisation and in Acute Otitis Media

Väitöskirj

Vielä B-hepatiitin kantajan raskaudesta

Kommentti Martti Färkkilän ja Aila Tiitisen artikkeliin Duodecim 132(18):1726-1731, 2016Non peer reviewe

Maahanmuuttajien tärkeimmät trooppiset taudit

•Troop­pis­ten tau­tien epäi­ly vaa­tii usein oi­val­lus­ta, diag­nos­tiik­ka ja hoi­to eri­tyi­so­saa­mis­ta. •Ma­la­ria voi oi­reil­la vuo­sien ku­lut­tua maa­han­muu­tos­ta. Ras­kau­de­nai­kai­nen ane­mia voi joh­tua oi­reet­to­mas­ta, subk­lii­ni­ses­tä ma­la­rias­ta. •Kroo­ni­nen iho­haa­vau­ma voi ol­la iho­leish­ma­niaa­si, mut­ta tau­ti voi il­me­tä myös va­ka­va­na vis­ke­raa­li­se­na ­leish­ma­niaa­si­na. •Eo­si­no­fii­li­ta­so voi ol­la ko­hon­nut ku­dos­ma­to­tau­dis­sa, he­ma­tu­ria voi joh­tua skis­to­so­miaa­sis­ta ja kys­ta mak­sas­sa voi ol­la eki­no­kok­koo­si. •In­fek­tio­ris­ki riip­puu maa­han­muut­ta­jan läh­tö­maas­ta, kaut­ta­kul­ku­rei­teis­tä ja olo­suh­teis­ta en­nen Suo­meen saa­pu­mis­ta.Peer reviewe

Childhood nontuberculous mycobacterial lymphadenitis –observation alone is a good alternative to surgery

Objective Cervicofacial lymphadenitis caused by nontuberculous mycobacteria (NTM) is commonly treated with surgery or antimicrobial therapy. The aim of this study was to analyze the utility of our new blood-based diagnostic method and the treatment protocol, surgery or observation alone, in NTM lymphadenitis in children. Methods All patients under 16 years of age with cervicofacial NTM lymphadenitis diagnosed and treated at Children’s Hospital or at the Department of Otorhinolaryngology, Helsinki University Hospital (Helsinki, Finland) in 2007-2017 were retrospectively reviewed. Results Fifty-two patients, 33 (63%) of whom were girls, were included in the study. The median age at initial presentation of the NTM lymphadenitis was 2.9 years. The novel blood-test had been performed on 49 (94%) of the patients and in all of them it was indicative of NTM infection. A sample for mycobacterial culture was available from 34 patients, and Mycobacterium avium was the most common species detected. Most patients (n=33, 63%) were treated conservatively with observation alone. Of these, nine patients (27%) did not develop a skin fistula, and the lymphadenitis resolved without drainage. Conclusions The novel blood test is clinically feasible method for diagnosing childhood cervicofacial NTM lymphadenitis noninvasively. Observation alone is a good alternative to surgery, without the risk of complications.Peer reviewe

A case of congenital tuberculosis with a favorable outcome in a full term neonate

This case of congenital tuberculosis (TB) emphasizes that TB should be suspected in newborns whose parents are from areas with high incidence of TB or who present with symptoms of an infection unresponsive to wide-spectrum antibiotics.Peer reviewe