Some recent results in aerospace vehicle trajectory optimization techniques

Algorithms and computation techniques for solving trajectory optimization problem

When to consult a geneticist specialising in gestational trophoblastic disease

Background: Gestational trophoblastic disease comprises hydatidiform moles and a rare group of malignancies that derive from trophoblasts. Although there are typical morphological features that may distinguish hydatidiform moles from non-molar products of conception, such features are not always present, especially at early stages of pregnancy. Furthermore, mosaic/chimeric pregnancies and twin pregnancies make pathological diagnosis challenging while trophoblastic tumours can also pose diagnostic problems in terms of their gestational or non-gestational origin. Objectives: To show that ancillary genetic testing can be used to aid diagnosis and clinical management of GTD. Methods: Each author identified cases where genetic testing, including short tandem repeat (STR) genotyping, ploidy analysis, next generation sequencing and immunostaining for p57, the product of the imprinted gene CDKN1C, facilitated accurate diagnosis and improved patient management. Representative cases were chosen to illustrate the value of ancillary genetic testing in different scenarios. Outcome: Genetic analysis of placental tissue can aid in determining the risk of developing gestational trophoblastic neoplasia, facilitating discrimination between low risk triploid (partial) and high risk androgenetic (complete) moles, discriminating between a hydatidiform mole twinned with a normal conceptus and a triploid conception and identification of androgenetic/biparental diploid mosaicism. STR genotyping of placental tissue and targeted gene sequencing of patients can identify women with an inherited predisposition to recurrent molar pregnancies. Genotyping can distinguish gestational from non-gestational trophoblastic tumours using tissue or circulating tumour DNA, and can also identify the causative pregnancy which is the key prognostic factor for placental site and epithelioid trophoblastic tumours. Conclusions and Outlook: STR genotyping and P57 immunostaining have been invaluable to the management of gestational trophoblastic disease in many situations. The use of next generation sequencing and of liquid biopsies are opening up new pathways for GTD diagnostics. Development of these techniques has the potential to identify novel biomarkers of GTD and further refine diagnosis

Planar Laser Induced Fluorescence Mapping of a Carbon Laser Produced Plasma

We present measurements of ion velocity distribution profiles obtained by laser induced fluorescence (LIF) on an explosive laser produced plasma (LPP). The spatio-temporal evolution of the resulting carbon ion velocity distribution was mapped by scanning through the Doppler-shifted absorption wavelengths using a tunable, diode-pumped laser. The acquisition of this data was facilitated by the high repetition rate capability of the ablation laser (1 Hz) which allowed the accumulation of thousand of laser shots in short experimental times. By varying the intensity of the LIF beam, we were able to explore the effects of fluorescence power against laser irradiance in the context of evaluating the saturation versus the non-saturation regime. The small beam size of the LIF beam led to high spatial resolution of the measurement compared to other ion velocity distribution measurement techniques, while the fast-gated operation mode of the camera detector enabled the measurement of the relevant electron transitions

Effective thermal conductivity of a thin composite material

The thermal conductivity of a randomly oriented composite material is modeled using a probabilistic approach in order to determine if a size effect exists for the thermal conductivity at small composite thickness. The numerical scheme employs a random number generator to position the filler elements, which have a relatively high thermal conductivity, within a matrix having a relatively low thermal conductivity. Results indicate that, below some threshold thickness, the composite thermal conductivity increases with decreasing thickness, while above the threshold the thermal conductivity is independent of thickness. The threshold thickness increases for increasing filler fraction and increasing k{sub f}/k{sub m}, the ratio between filler and matrix thermal conductivities

Diel and seasonal methane dynamics in the shallow and turbulent Wadden Sea

The Wadden Sea is a coastal system along the fringe of the land–sea borders of Denmark, Germany and the Netherlands. The Wadden Sea is extremely productive and influenced by strong variations in physical and biological forcing factors that act on timescales of hours to seasons. Productive coastal seas are known to dominate the ocean's methane emission to the atmosphere, but knowledge of controls and temporal variations in methane dynamics in these vastly dynamic systems is scarce. Here we address this knowledge gap by measuring methane inventories and methanotrophic activity at a temporal resolution of 1 h over a period of 2 d, repeatedly during four successive seasons in the central Dutch Wadden Sea. We found that methane dynamics varied between colder and warmer seasons, with generally higher water column methane concentrations and methanotrophic activity in the warmer seasons. The efflux of methane to the atmosphere was, on the other hand, lower in the warmer seasons because of lower wind speeds. On a diel scale, tides controlled methanotrophic activity, which increased ∼40 % at low tide compared to high tide. We estimate that methane oxidizing bacteria reduce the methane budget of the Dutch Wadden Sea by only 2 %, while ∼1/3 escapes to the atmosphere and ∼2/3 are flushed out into the open North Sea at ebb tide. Our findings indicate that tides play a key role in controlling methane dynamics and methanotrophic activity and highlight the importance of high-resolution and repeated sampling strategies to resolve methane dynamics in fast-changing coastal systems.</p

High-temperature superconductor coil system for a particle detector analyzing magnet

The high energy physics experiment known as the Main Injector Neutrino Oscillation Search (MINOS), which is intended for the study of neutrinos, will incorporate a large particle detector system. The detector employs an analyzing magnetic field generated by magnetizing an array of steel plates, called absorbers, with a current-carrying coil. We have evaluated the feasibility of a high-temperature superconductor coil system that provides a 25,000 A-turn magnetizing force. An equivalent conventional coil system (i.e., water-cooled copper) was also designed for comparison

Income-Related Minimum Taxation Concepts and Their Impact on Corporate Investment Decisions

In this paper we analyze the impact of various minimum taxation concepts on corporate investment decisions. These investments can be realized in the form of either a real or a financial investment. In a quantitative analysis we refer to the future values of the investments as an indicator of tax-favored and tax-discriminated projects. Varying the concept-specific loss-offset parameters and cash flow time structure and performing a Monte Carlo simulation reveals the impact of the particular minimum taxation concept. For the first time a comprehensive set of equations has been deduced to integrate different minimum tax concepts in a unique model. The resulting equations can be used as a basis for further analyses of group taxation, wealth taxation and asymmetric taxation and allows us to gain first insights into the direction and magnitude of tax distortions of possible competing concepts. Depending on the set of parameters, complex and ambiguous tax effects can be identified. The effect of minimum taxation depends on the existence and magnitude of a depreciation effect. Both effects run contrary to each other, and the depreciation effect is always greater. We find that all concepts distort in the same direction and that real investments with increasing cash flows are more likely to be discriminated by minimum taxation than financial investments or real investments with constant cash flows. However, in comparison to real investments with decreasing cash flows financial investments suffer more from income-related minimum taxation concepts. These results provide interesting information for corporate investors having to decide on the location of an investment, and for tax reform discussions

Multilayer insulation (MLI) in the Superconducting Super Collider: A practical engineering approach to physical parameters governing MLI thermal performance

Multilayer insulation (MLI) is employed in cryogenic devices to control the heat load of those devices. The physics defining the thermal performance of an MLI system is extremely complex due to the thermal dynamics of numerous interdependent parameters which in themselves contribute differently depending on whether boundary conditions are transient or steady-state. The Multilayer Insulation system for the Superconducting Super Collider (SSC) consists of full cryostat length assemblies of aluminized polyester film, fabricated in the form of blankets, and installed as blankets to the 4.5K cold mass, and the 20K and 80K thermal radiation shields. Approximately 40,000 blankets will be required in the 10,000 cryogenic devices comprising the SSC accelerator. Each blanket will be nearly 56 feet long by 6 feet wide and will consist of as many as 32 reflective and 31 spacer layers of material. Discussed are MLI material choices, and the physical parameters which contribute to the operational performance of MLI systems. Disclosed is a method for fabricating MLI blankets by employing a large diameter winding mandrel having a circumference sufficient for the required blanket length. The blanket fabrication method assures consistency in mass produced MLI blankets by providing positive control of the dimensional parameters which contribute to the MLI blanket thermal performance. The fabrication method can be used to mass produce prefabricated MLI blankets that by virtue of the product have inherent features of dimensional stability, three-dimensional uniformity, controlled layer density, layer-to-layer registration, interlayer cleanliness, and interlayer material to accommodate thermal contraction differences. 9 refs., 4 figs., 2 tabs

How much laser power can propagate through fusion plasma?

Propagation of intense laser beams is crucial for inertial confinement fusion, which requires precise beam control to achieve the compression and heating necessary to ignite the fusion reaction. The National Ignition Facility (NIF), where fusion will be attempted, is now under construction. Control of intense beam propagation may be ruined by laser beam self-focusing. We have identified the maximum laser beam power that can propagate through fusion plasma without significant self-focusing and have found excellent agreement with recent experimental data, and suggest a way to increase that maximum by appropriate choice of plasma composition with implication for NIF designs. Our theory also leads to the prediction of anti-correlation between beam spray and backscatter and suggests the indirect control of backscatter through manipulation of plasma ionization state or acoustic damping.Comment: 15 pages, 4 figures, submitted to Plasma Physics and Controlled Fusio