Managing Mentoring Concepts of Educational Sciences at the University of Duisburg-Essen

The university-wide mentoring system of the University of Duisburg-Essen pursues systematic, continuous and individual counseling for all students. The Faculty of Educational Science therefore offers different mentoring concepts according to its study programs considering not only the students' demand but also their course content and job prospects in order to enhance their autonomy. Existing counseling services of the university are involved and different mentoring programs are linked so that synergies regarding content and organization are leveraged and a matching appearance is maintained. 14.02.2014 | Julia Niemann (Essen

Umlenkung antiviraler Antikörper gegen solide Tumore durch den Einsatz bispezifischer Adapterproteine

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Process optimization and intensification of AAV2 vector production: Scale down and rapid scale up upstream processes

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Outlining the way ahead in computational communication science: an introduction to the IJoC special section on „Computational Methods for Communication Science: Toward a Strategic Roadmap“

Over the past two decades, processes of digitalization and mediatization have shaped the communication landscape and have had a strong impact on various facets of communication. The digitalization of communication results in completely new forms of digital traces that make communication processes observable in new and unprecedented ways. Although many scholars in the social sciences acknowledge the chances and requirements of the digital revolution in communication, they are also facing fundamental challenges in implementing successful research programs, strategies, and designs that are based on computational methods and “big data.” This Special Section aims at bringing together seminal perspectives on challenges and chances of computational communication science (CCS). In this introduction, we highlight the impulses provided by the research presented in the Special Section, discuss the most pressing challenges in the context of CCS, and sketch a potential roadmap for future research in this field

Use of a parallel bioreactor scaledown system for optimisation of a perfusion-based upstream process for adenovirus production

The recent pandemic emphasises the need for vaccine producers to be able to respond rapidly to the need for large quantities for global distribution. Here, we report work to optimise a perfusion-based upstream approach. Perfusion can enhance volumetric productivity of adenoviral vectors, but the complexity of perfusion culture and the lack of suitable scale-down models has hindered work to establish the complex relationships between variables affecting the process. Please click Download on the upper right corner to see the full abstract

Rapid intensification of an established CHO cell fed-batch process

Currently, the mammalian biomanufacturing industry explores process intensification (PI) to meet upcoming demands of biotherapeutics while keeping production flexible but, more importantly, as economic as possible. However, intensified processes often require more development time compared with conventional fed-batches (FBs) preventing their implementation. Hence, rapid and efficient, yet straightforward strategies for PI are needed. In this study we demonstrate such a strategy for the intensification of an N-stage FB by implementing N-1 perfusion cell culture and high inoculum cell densities resulting in a robust intensified FB (iFB). Furthermore, we show successful combination of such an iFB with the addition of productivity enhancers, which has not been reported so far. The conventional CHO cell FB process was step-wise improved and intensified rapidly in multi-parallel small-scale bioreactors using N-1 perfusion. The iFBs were performed in 15 and 250 ml bioreactors and allowed to evaluate the impact on key process indicators (KPI): the space–time yield (STY) was successfully doubled from 0.28 to 0.55 g/L d, while product quality was maintained. This gain was generated by initially increasing the inoculation density, thus shrinking process time, and second supplementation with butyric acid (BA), which reduced cell growth and enhanced cell-specific productivity from ~25 to 37 pg/(cell d). Potential impacts of PI on cell metabolism were evaluated using flux balance analysis. Initial metabolic differences between the standard and intensified process were observed but disappeared quickly. This shows that PI can be achieved rapidly for new as well as existing processes without introducing sustained changes in cellular and metabolic behavior.publishedVersio

Prolonged rectal shedding of SARS-CoV-2 in a 22-day-old-neonate:a case report

Abstract Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes the novel coronavirus disease 2019 (COVID-19), which is characterized by a diverse clinical picture. Children are often asymptomatic or experience mild symptoms and have a milder disease course compared to adults. Rectal shedding of SARS-CoV-2 has been observed in both adults and children, suggesting the fecal-oral route as a potential route of transmission. However, only a few studies have investigated this in neonates. We present a neonate with a mild disease course and prolonged rectal SARS-CoV-2 shedding. Case presentation A 22-day old neonate was admitted to the hospital with tachycardia and a family history of COVID-19. The boy later tested positive for COVID-19. His heart rate normalized overnight without intervention , but a grade 1/6 heart murmur on the left side of the sternum was found. After excluding signs of heart failure, the boy was discharged in a habitual state after three days of admission. During his admission, he was enrolled in a clinical study examining the rectal shedding of SARS-CoV-2. He was positive for SARS-CoV-2 in his pharyngeal swabs for 11 days after initial diagnosis and remained positive in his rectal swabs for 45 days. Thereby, the boy remained positive in his rectal swabs for 29 days after his first negative pharyngeal swab. Conclusions The presented case shows that neonates with a mild disease course can shed SARS-CoV-2 in the intestines for 45 days. In the current case, it was not possible to determine if fecal-oral transfer to the family occurred, and more research is needed to establish the potential risk of the fecal-oral transmission route

Fast adiabatic transport of single laser-cooled 9Be+ ions in a cryogenic Penning trap stack

High precision mass and g-factor measurements in Penning traps have enabled groundbreaking tests of fundamental physics. The most advanced setups use multi-trap methods, which employ transport of particles between specialized trap zones. Present developments focused on the implementation of sympathetic laser cooling will enable significantly shorter duty cycles and better accuracies in many of these scenarios. To take full advantage of these increased capabilities, we implement fast adiabatic transport concepts developed in the context of trapped-ion quantum information processing in a cryogenic Penning trap system. We show adiabatic transport of a single 9Be+ ion initially cooled to 2 mK over a 2.2-cm distance within 15 ms and with less than 10 mK energy gain at a peak velocity of 3 m/s. These results represent an important step towards the implementation of quantum logic spectroscopy in the (anti-)proton system. Applying these developments to other multi-trap systems has the potential to considerably increase the data-sampling rate in these experiments

The national research data infrastructure—a solution for infrastructural needs of content analysis?

Obwohl die Inhaltsanalyse eine zentrale Stellung in der Kommunikations- und Medienforschung besitzt, existieren kaum Forschungsinfrastrukturen für diese Methode. Gleichzeitig werden in Deutschland seit 2018 große Dateninfrastrukturen in den 27 Konsortien der Nationalen Forschungsdateninfrastruktur (NFDI) aufgebaut. In diesem Beitrag gehen wir aus Perspektive der Forschenden der Frage nach, inwiefern die NFDI-Konsortien Lösungen für die infrastrukturellen Anforderungen in Bezug auf Inhaltsanalysen bieten. Zunächst beleuchten wir diese Anforderungen entlang des Forschungsdaten-Lebenszyklus und identifizieren Leerstellen. Dann explorieren wir, welche Bedarfe die NFDI-Konsortien decken können. Der Schwerpunkt liegt auf Konsortien, die sich auf die Sammlung und Aufbereitung von Text oder multimodalen Daten konzentrieren: KonsortSWD, BERD@NFDI, Text+, NFDI4Memory, NFDI4Culture und NFDI4DataScience. Unsere Untersuchung zeigt, dass die Konsortien bereits viele der Bedarfe abdecken. Allerdings gibt es weder ein Konsortium, in dem Kommunikationswissenschaftler:innen treibende Kräfte sind, noch wird die Inhaltsanalyse explizit berücksichtigt. Wir diskutieren, wie sich Forschungsinfrastrukturen für die Inhaltsanalyse durch die NFDI-Strukturen weiterentwickeln ließen.Content analysis has a central position in media and communication research, yet research infrastructures for the method are still scarce. At the same time, the 27 consortia of the National Research Data Infrastructure (NFDI) have started to establish large data infrastructures in Germany since 2018. In this paper, we explore from the perspective of researchers whether the NFDI consortia provide solutions to the infrastructural needs of content analysis. First, we illustrate these needs throughout the research data lifecycle and identify shortcomings. We then explore whether the NFDI consortia can meet these needs. The focus lies on consortia that concentrate on the collection and processing of text or multimodal data: KonsortSWD, BERD@NFDI, Text+, NFDI4Memory, NFDI4Culture, and NFDI4DataScience. Our exploration shows that many of the needs are already being addressed by the consortia. However, there is no consortium in which communication scholars are the driving force and content analysis does not receive explicit consideration. We discuss how research infrastructures for content analysis can be further developed through the NFDI structures