1,285 research outputs found
Single-crown restorations supported by short implants (6 mm) compared with standard-length implants (13 mm) in conjunction with maxillary sinus floor augmentation:a randomized, controlled clinical trial
BACKGROUND: The purpose of the present study was to test the H0-hypothesis of no difference in the clinical and radiographical treatment outcome of single-crown restorations supported by short implants compared with standard length implants in conjunction with maxillary sinus floor augmentation (MSFA) after 1 year of functional implant loading. Forty patients with partial edentulism in the posterior part of the maxilla were randomly allocated to treatment involving single-crown restorations supported by short implants or standard length implants in conjunction with MSFA. Clinical and radiographical evaluation were used to assess survival of suprastructures and implants, peri-implant marginal bone loss (PIMBL), biological, and mechanical complications. RESULTS: Both treatment modalities were characterized by 100% survival of suprastructures and implants after 1 year. Mean PIMBL was 0.60 mm with short implants compared with 0.51 mm with standard length implants after 1 year of functional loading. There were no statistically significant differences in survival of suprastructure and implants, PIMBL, and mechanical complications between the two treatment modalities. However, a higher incidence of biological complications was associated with standard length implants in conjunction with MSFA. CONCLUSION: Within the limitations of the present study, it can be concluded that single-crown restorations supported by short implants seems to be comparable with standard length implants in conjunction with MSFA. However, long-term studies are needed before final conclusions can be provided about the two treatment modalities. TRIAL REGISTRATION: Clinicaltrials.Gov ID: NCT04518020. Date of registration: August 14, 2020, retrospectively registered
Cryogen-Free dissolution Dynamic Nuclear Polarization polarizer operating at 3.35 T, 6.70 T and 10.1 T
Purpose: A novel dissolution dynamic nuclear polarization (dDNP) polarizer
platform is presented. The polarizer meets a number of key requirements for in
vitro, pre-clinical and clinical applications. Method: It uses no liquid
cryogens, operates in continuous mode, accommodates a wide range of sample
sizes up to and including those required for human studies, and is fully
automated. Results: It offers a wide operational window both in terms of
magnetic field, up to 10.1 T, and temperature, from room temperature down to
1.3 K. The polarizer delivers a 13C liquid state polarization for
[1-13C]pyruvate of 70%. The build-up time constant in the solid state is
approx. 1200 s (20 min), allowing a sample throughput of at least one sample
per hour including sample loading and dissolution. Conclusion: We confirm the
previously reported strong field dependence in the range 3.35 to 6.7 T, but see
no further increase in polarization when increasing the magnetic field strength
to 10.1 T for [1-13C]pyruvate and trityl. Using a custom dry magnet, cold head
and recondensing, closed-cycle cooling system, combined with a modular DNP
probe, automation and fluid handling systems; we have designed a unique dDNP
system with unrivalled flexibility and performance.Comment: 16 pages, 8 figure
Gene variation in IL-7 receptor (IL-7R)Îą affects IL-7R response in CD4+ T cells in HIV-infected individuals
Optimal CD4+ T cell recovery after initiating combination antiretroviral treatment (cART) in HIV infection reduces risk of morbidity and mortality. T-allele homozygosity (âTTâ) in the single nucleotide polymorphism, rs6897932(C/T), in the IL-7 receptor Îą (IL-7RA) is associated with faster CD4+ T cell recovery after cART initiation compared to C-allele homozygosity in rs6897932 (âCCâ). However, underlying mechanisms are unknown. We aimed to examine potential mechanisms explaining the association between rs6897932 and CD4+ T cell recovery. Ten âTTâ and 10 âCCâ HIV-infected individuals matched on gender, age, and nadir and current CD4+ T cell counts were included in a cross-sectional study. âTTâ individuals had higher proportion of CD4+ T cells expressing pSTAT5 compared to âCCâ individuals after stimulating with IL-7, especially when co-stimulated with soluble IL7-RA (sIL-7RA). Furthermore, âTTâ individuals had a higher proportion of proliferating CD4+ T cells after 7 days of culture with IL-7â+âsIL-7RA compared to âCCâ individuals. No differences between âTTâ and âCCâ in binding of biotinylated IL-7 were found. In conclusion, increased signal transduction and proliferation in response to IL-7 was found in âTTâ compared to âCCâ HIV-infected individuals providing a mechanistic explanation of the effect of rs6897932 T-allele on CD4+ T cell recovery in HIV infection
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