The financial position of British households: evidence from the 2010 NMG Consulting survey

The UK economy has begun to recover over the past year but households’ financial positions remain under strain. Elevated unemployment, weak earnings growth and restricted credit availability still pose a problem for some households. But the low level of Bank Rate has continued to bear down on mortgage interest payments for some borrowers. This article examines evidence from the latest survey of households carried out for the Bank by NMG Consulting in late September, which shows how these and other changes have affected households’ budgets and spending decisions. The burden of unsecured debt was higher than in the past and concerns about debt levels had increased, leading some to save more in order to reduce indebtedness. A special set of questions this year showed that households’ awareness of the fiscal consolidation measures was quite high. They were concerned about the impact on their finances, although the majority had yet to take any action in response.

Spatial aspects of the design and targeting of agricultural development strategies:

Two increasingly shared perspectives within the international development community are that (a) geography matters, and (b) many government interventions would be more successful if they were better targeted. This paper unites these two notions by exploring the opportunities for, and benefits of, bringing an explicitly spatial dimension to the tasks of formulating and evaluating agricultural development strategies. We first review the lingua franca of land fragility and find it lacking in its capacity to describe the dynamic interface between the biophysical and socioeconomic factors that help shape rural development options. Subsequently, we propose a two-phased approach. First, development strategy options are characterized to identify the desirable ranges of conditions that would most favor successful strategy implementation. Second, those conditions exhibiting important spatial dependency – such as agricultural potential, population density, and access to infrastructure and markets – are matched against a similarly characterized, spatially-referenced (GIS) database. This process generates both spatial (map) and tabular representations of strategy-specific development domains. An important benefit of a spatial (GIS) framework is that it provides a powerful means of organizing and integrating a very diverse range of disciplinary and data inputs. At a more conceptual level we propose that it is the characterization of location, not the narrowly-focused characterization of land, that is more properly the focus of attention from a development perspective. The paper includes appropriate examples of spatial analysis using data from East Africa and Burkina Faso, and concludes with an appendix describing and interpreting regional climate and soil data for Sub-Saharan Africa that was directly relevant to our original goal.Spatial analysis (Statistics), Agricultural development., Burkina Faso., Africa, Sub-Saharan.,

Demographic effects on fruit set in the dioecious shrub Canada buffaloberry (Shepherdia canadensis)

The effects of pollen limitation on reproductive success in plants have been well-documented using pollen supplementation experiments. However, the role of local demographics in determining pollen limitation, particularly in terms of the additive and interactive effects of pollen availability and competition are not well known. We measured fruit set in the dioecious shrub Canada buffaloberry (Shepherdia canadensis) in Central Alberta, Canada to evaluate whether local demographics measured at three spatial scales (25, 50, and 100 m2) affect fruit set in buffaloberry. We test whether density-dependence (population density), pollen donor (measured as male density, distance to nearest male plant and size of nearest male plant), female competitor (measured as female density and distance to nearest female plant), or the combined pollen donor and competitor hypotheses best explain natural variations in fruit set for a population of Canada buffaloberry. Support was highest for the combined pollen donor and competitor hypothesis at an intermediate spatial scale of 50 m2. Proportion fruit set increased with male shrub density (pollen donors) and decreased with female shrub density (pollen competitors), but was more affected by the presence of males than females. This illustrates that access to male shrubs within a 3.99 m radius affects pollen availability, while nearby females compete intra-specifically for pollen

Impacts of the biomass producer or collector tax credit on Oregon's wood fuels market and economy

32 pagesOregon’s Biomass Producer or Collector (BPC) Tax Credit encourages the production, collection, and transportation of biomass for biofuel production. It helps offset the transportation costs for biomass producers and collectors for a variety of bioenergy feed stocks by paying a set rate per unit of material delivered to a qualified bioenergy facility. This report is intended to help evaluate the effects of the tax credit on the Oregon’s wood fuel market and Oregon’s economy more broadly.This working paper was completed in response to a request from the Oregon Department of Energy. We thank John Pine and Andrew Herstrom with the Oregon Department of Forestry, and Gail Krumenauer with the State of Oregon Employment Department for their support through this project

3D printed sensing patches with embedded polymer optical fibre Bragg gratings

The first demonstration of a polymer optical fibre Bragg grating (POFBG) embedded in a 3-D printed structure is reported. Its cyclic strain performance and temperature characteristics are examined and discussed. The sensing patch has a repeatable strain sensitivity of 0.38 pm/μepsilon. Its temperature behaviour is unstable, with temperature sensitivity values varying between 30-40 pm/°C

Bottleneck and selection in the germline and maternal age influence transmission of mitochondrial DNA in human pedigrees.

Heteroplasmy-the presence of multiple mitochondrial DNA (mtDNA) haplotypes in an individual-can lead to numerous mitochondrial diseases. The presentation of such diseases depends on the frequency of the heteroplasmic variant in tissues, which, in turn, depends on the dynamics of mtDNA transmissions during germline and somatic development. Thus, understanding and predicting these dynamics between generations and within individuals is medically relevant. Here, we study patterns of heteroplasmy in 2 tissues from each of 345 humans in 96 multigenerational families, each with, at least, 2 siblings (a total of 249 mother-child transmissions). This experimental design has allowed us to estimate the timing of mtDNA mutations, drift, and selection with unprecedented precision. Our results are remarkably concordant between 2 complementary population-genetic approaches. We find evidence for a severe germline bottleneck (7-10 mtDNA segregating units) that occurs independently in different oocyte lineages from the same mother, while somatic bottlenecks are less severe. We demonstrate that divergence between mother and offspring increases with the mother's age at childbirth, likely due to continued drift of heteroplasmy frequencies in oocytes under meiotic arrest. We show that this period is also accompanied by mutation accumulation leading to more de novo mutations in children born to older mothers. We show that heteroplasmic variants at intermediate frequencies can segregate for many generations in the human population, despite the strong germline bottleneck. We show that selection acts during germline development to keep the frequency of putatively deleterious variants from rising. Our findings have important applications for clinical genetics and genetic counseling

Community-Based Natural Resource Management in the Western United States: A Pilot Study of Capacity

32 pagesThis paper was made possible by grants from the Ford Foundation, U.S. Endowment for Forestry and Communities, and U.S.D.A. Rural Development

Proteome reallocation from amino acid biosynthesis to ribosomes enables yeast to grow faster in rich media

Several recent studies have shown that the concept of proteome constraint, i.e., the need for the cell to balance allocation of its proteome between different cellular processes, is essential for ensuring proper cell function. However, there have been no attempts to elucidate how cells\u27 maximum capacity to grow depends on protein availability for different cellular processes. To experimentally address this, we cultivated Saccharomyces cerevisiae in bioreactors with or without amino acid supplementation and performed quantitative proteomics to analyze global changes in proteome allocation, during both anaerobic and aerobic growth on glucose. Analysis of the proteomic data implies that proteome mass is mainly reallocated from amino acid biosynthetic processes into translation, which enables an increased growth rate during supplementation. Similar findings were obtained from both aerobic and anaerobic cultivations. Our findings show that cells can increase their growth rate through increasing its proteome allocation toward the protein translational machinery

Embedding silica and polymer fibre Bragg gratings (FBG) in plastic 3D-printed sensing patches

This paper reports the first demonstration of a silica fibre Bragg grating (SOFBG) embedded in an FDM 3-D printed housing to yield a dual grating temperature-compensated strain sensor. We also report the first ever integration of polymer fibre Bragg grating (POFBG) within a 3-D printed sensing patch for strain or temperature sensing. The cyclic strain performance and temperature characteristics of both devices are examined and discussed. The strain sensitivities of the sensing patches were 0.40 and 0.95 pm/μϵ for SOFBG embedded in ABS, 0.38 pm/μμ for POFBG in PLA, and 0.15 pm/μμ for POFBG in ABS. The strain response was linear above a threshold and repeatable. The temperature sensitivity of the SOFBG sensing patch was found to be up to 169 pm/°C, which was up to 17 times higher than for an unembedded silica grating. Unstable temperature response POFBG embedded in PLA was reported, with temperature sensitivity values varying between 30 and 40 pm/°C

Proteome allocations change linearly with the specific growth rate of Saccharomyces cerevisiae under glucose limitation

Saccharomyces cerevisiae is a widely used cell factory; therefore, it is important to understand how it organizes key functional parts when cultured under different conditions. Here, we perform a multiomics analysis of S. cerevisiae by culturing the strain with a wide range of specific growth rates using glucose as the sole limiting nutrient. Under these different conditions, we measure the absolute transcriptome, the absolute proteome, the phosphoproteome, and the metabolome. Most functional protein groups show a linear dependence on the specific growth rate. Proteins engaged in translation show a perfect linear increase with the specific growth rate, while glycolysis and chaperone proteins show a linear decrease under respiratory conditions. Glycolytic enzymes and chaperones, however, show decreased phosphorylation with increasing specific growth rates; at the same time, an overall increased flux through these pathways is observed. Further analysis show that even though mRNA levels do not correlate with protein levels for all individual genes, the transcriptome level of functional groups correlates very well with its corresponding proteome. Finally, using enzyme-constrained genome-scale modeling, we find that enzyme usage plays an important role in controlling flux in amino acid biosynthesis. Understanding how yeast organizes its functional proteome is a fundamental task in systems biology. Here, the authors conduct a multiomics analysis on yeast cells cultured with different growth rates, identifying a linear dependence of the functional proteome on the growth rate