Must Curriculum Based Measurement Reading Probes Be Curriculum Based?

Curriculum-based measurement (CBM) has evolved as a reliable and valid method for measuring and monitoring student performance in basic academic skills. While the efficacy of CBM for assessing reading skills is not in question, there is some confusion regarding the type of CBM reading passages (called probes) that should be used. Specifically, it is unclear whether or not there is a difference between CBM probes derived directly from the instructional curriculum and generic probes derived from a pre-printed source. The current study compare the utility of two types of CBM reading probe materials. One probe type is derived from curriculum-dependent passages taken directly from a phonics-based reading instruction curriculum and the second from the Tests of Reading Fluency (TORF), a set of generic (curriculum-independent) passages. Both types of probes were administered to 13 second grade students twice weekly for 5 weeks. The median number of words read per minute for each probe type were compared. No significant differences were found between the two probes\u27 in terms of ability to measure current levels of progress and performance over time. Implications of the study, outcomes for school psychology and potential for further research are discussed

The Effects of Patellofemoral Taping on Patellofemoral Joint Alignment and Contact Area

Purpose/Hypothesis: It is widely accepted that patellofemoral pain (PFP) is the result of excessive stress between the retro-patellar surface and the femoral trochlea. Elevated patellofemoral joint (PFJ) stress may be associated with a reduction in PFJ contact area resulting from patellar malalignment (e.g., lateral displacement, lateral tilt, or patellar alta and/or quadriceps imbalance). McConnell and Kinesio taping techniques are commonly used to address PFP and improve PFJ alignment. It has been theorized that PFJ taping can alter the PFJ alignment which may increase the patella’s contact area within the femoral trochlea, thereby resulting in a reduction in PFP. To date, the effects of these 2 taping approaches on PFJ contact area and PFJ alignment have not yet been studied thoroughly. The primary purpose of this study was to use magnetic resonance imaging (MRI) to examine the effects of patellofemoral taping techniques on PFJ alignment and contact area in persons with PFP at 3 knee joint angles (0°, 20°, and 40°). Number of Subjects: Fourteen female subjects with retropatellar pain and PFJ malalignment participated (age: 27.86 ± 5.95 years; weight: 72.15 ± 19.27 kg; height: 1.67 ± .08 m). Methods: Each subject underwent a pre-taping magnetic resonance imaging (MRI) scan session and 2 MRI scan sessions after the application of the 2 taping techniques aiming to correct lateral patellar displacement. Subjects were asked to report their pain using an 11- point numeric rating scale (NRS) while stepping down from a 23-cm step, before and after tape was administered. During each scan session, subjects were loaded with 25% of body weight on their involved/more symptomatic leg at 0°, 20°, and 40° of knee flexion. The outcome measures included patellar lateral displacement (bisect-offset (BSO) index), patellar mediolateral tilt (patellar tilt angle (PTA)), patellar position (Insall-Salvati ratio (ISR)), PFJ contact area, and NRS. PFJ alignment/contact area was compared among the 3 conditions (No tape, Kinesio, and McConnell) at 3 knee angles using a two-way ANOVA with repeated measures. Pain NRS was compared among the 3 conditions using Friedman test and post-hoc Wilcoxon signed-rank tests. Results: The results of the two-way ANOVAs revealed that neither McConnell nor Kinesio taping had significant effects on BSO index (p = 0.488), PTA (p = 0.558), ISR (p = 0.778), and contact area (p = 0.358) across the 3 knee flexion angles. Knee flexion angle had a significant effect on BSO index (p = 0.001) and contact area (p \u3c 0.001). The Friedman test revealed a significant difference in pain level among the 3 conditions. The post-hoc Wilcoxon signed-rank tests further demonstrated that there was a reduction in NRS during step-down test after the application of the Kinesio Taping technique (p=.007). Conclusions: In a weight-bearing condition, our results did not support the premise that applications of PFJ taping using a medial correction technique can alter the PFJ contact area or alignment of the patella. The reduction in pain, following the application of the Kinesio Taping technique performed in this study supports the previous literature on the use of Kinesio Taping techniques for pain management, although the underlying mechanism for the reduction of pain is unclear

The Improvement of Care in Patients with Pancreatic Cancer

Introduction: Pancreas adenocarcinoma (PDAC) remains a lethal malignancy with a high‐mortality rate and poor long‐term survival. The management of PDAC has evolved over the years to incorporate multidisciplinary care and numerous treatment modalities

Matrix metalloproteinase activities and their relationship with collagen remodelling in tendon pathology

Our aim was to correlate the activity of matrix metalloproteinases (MMPs) with denaturation and the turnover of collagen in normal and pathological human tendons. MMPs were extracted from ruptured supraspinatus tendons (n=10), macroscopically normal (‘control’) supraspinatus tendons (n=29) and normal short head of biceps brachii tendons (n=24). Enzyme activity was measured using fluorogenic substrates selective for MMP-1, MMP-3 and enzymes with gelatinolytic activity (MMP-2, MMP-9 and MMP-13). Collagen denaturation was determined by a-chymotrypsin digestion. Protein turnover was determined by measuring the percentage of d-aspartic acid (% d-Asp). Zymography was conducted to identity specific gelatinases. MMP-1 activity was higher in ruptured supraspinatus compared to control supraspinatus and normal biceps brachii tendons (70.9, 26.4 and 11.5 fmol/mg tendon, respectively;

Greater functional aerobic capacity predicts more effective pain modulation in older adults

poster abstractEndogenous pain inhibitory and facilitory function deteriorates with age, potentially placing older adults at greater risk for chronic pain. Prior research shows that self-reported physical activity predicts endogenous pain inhibitory capacity and facilitation of pain on quantitative sensory tests (QST) in healthy adults. Purpose: To investigate whether functional aerobic capacity and lower extremity strength in older adults cross-sectionally predicts pain sensitivity, pain inhibition following isometric exercise, and facilitation of pain during heat pain temporal summation (TS) tests. Methods: 42 subjects (10 male, 32 female, age=67.5±5.1) completed the 6-minute walk test (6MWT), 30-second chair stand test, and several QSTs. QSTs included: 1) Pain ratings (0-100 scale) during the submersion of the hand in a cold water bath (CWB), 2) heat pain threshold tests, 3) the amount of pain reduction following submaximal isometric exercise, and 4) degree of pain facilitation during temporal summation tests conducted at 44, 46, and 48°C. Responses on the QSTs were analyzed using hierarchical linear regression with meters on 6MWT and number of chair stands as final predictors. Results: After controlling for demographic and psychological factors, aerobic capacity on 6MWT significantly predicted CWB pain ratings (R2 change= 22.5%, Beta= -0.491), pain facilitation during TS trials at 44°C (R2 change= 16.7%, Beta= -0.446), and the amount of pain reduction following isometric exercise (R2 change= 20.7%, Beta= 0.393). All other analyses were not significant (P>0.05). Conclusions: Older adults exhibiting greater functional aerobic capacity displayed reduced cold pain sensitivity, reduced pain facilitory function, and increased pain inhibition following exercise. These findings suggest that increased aerobic fitness in older adults may be associated with more effective endogenous modulation of pain. This study was funded by the IUPUI School of PETM Faculty Research Opportunity Grant

Application of reactor engineering concepts in continuous flow chemistry : a review

The adoption of flow technology for the manufacture of chemical entities, and in particular pharmaceuticals, has seen rapid growth over the past two decades with the technology now blurring the lines between chemistry and chemical engineering. Current indications point to a future in which flow chemistry and related technologies will be a major player in modern chemical manufacturing and the 4th industrial revolution. In this review we highlight the application of new reactor configurations and designs in the context of either bespoke or commercial flow apparatus specifically related to microwave chemistry, photochemical transformations, electrochemical promoted reactions and multi-phasic reactions. In addition, we look at how 3D printing in reactor design and computer-aided automation is growing within the field and finally describe how innovative solutions are being developed to tackle challenging downstream processing operations.National Research Foundation, and Pelchem Pty Ltd.http://www.rsc.org/journals-books-databases/about-journals/reaction-chemistry-engineeringChemistr

Motherhood Together: Effects of an Adapted Prenatal Curriculum on Mother and Infant Outcomes

Background: Research shows that pregnant women experiencing housing insecurity are more likely to face barriers to prenatal care that can lead to negative health outcomes for both mother and infant. Previous studies have also shown that prenatal education programs provide pregnant mothers with the knowledge and resources that increase the likelihood of positive health outcomes. An interprofessional healthcare team in Central Arkansas modified an existing prenatal education program to create Motherhood Together, a program specifically tailored for pregnant women facing house insecurity. Methods: The purpose of this initial evaluation of the Motherhood Together program was to identify the feasibility of the program and preliminary outcomes. This evaluation sought to better understand the demographic composition of the population participating in Motherhood Together (n = 19), as well as the effect of the program on infant outcomes, health literacy, and maternal self-care. The overall participant experience and feedback to enhance the program was also obtained. Results: The average age of participants was 24.6 years old and 77.8% reported high school as their highest level of educational attainment. The majority of participants identified as Black/African American (77.8%) and 22.2% identified as White. Participants scored the experience of Motherhood Together sessions positively with an overall score of 3.75/4.00. Participants reported an average gestational age at delivery being 36.9 weeks with 25% reporting preterm births following the program. Multivitamins were reported as being taken by 100% of participants following participation. Conclusion: Tailoring the pre-existing educational program to create the Motherhood Together program was clearly feasible and continues to serve as a critical resource for improving equity in infant and maternal outcomes in central Arkansas

Practical suggestions for harms reporting in exercise oncology : the Exercise Harms Reporting Method (ExHaRM)

The volume of high-quality evidence supporting exercise as beneficial to cancer survivors has grown exponentially; however, the potential harms of exercise remain understudied. Consequently, the trade-off between desirable and undesirable outcomes of engaging in exercise remains unclear to clinicians and people with cancer. Practical guidance on collecting and reporting harms in exercise oncology is lacking. We present a harms reporting protocol developed and refined through exercise oncology trials since 2015. Development of the Exercise Harms Reporting Method (ExHaRM) was informed by national and international guidelines for harms reporting in clinical trials involving therapeutic goods or medical devices, with adaptations to enhance applicability to exercise. The protocol has been adjusted via an iterative process of implementation and adjustment through use in multiple exercise oncology trials involving varied cancer diagnoses (types: breast, brain, gynaecological; stages at diagnosis I–IV; primary/ recurrent), and heterogeneous exercise intervention characteristics (face to face/telehealth delivery; supervised/unsupervised exercise). It has also involved the development of terms (such as, adverse outcomes, which capture all undesirable physical, psychological, social and economic outcomes) that facilitate the harms assessment process in exercise. ExHaRM involves: step 1: Monitor occurrence of adverse outcomes through systematic and non-systematic surveillance; step 2: Assess and record adverse outcomes, including severity, causality, impact on intervention and type; step 3: Review of causality by harms panel (and revise as necessary); and step 4: Analyse and report frequencies, rates and clinically meaningful details of all-cause and exercise-related adverse outcomes. ExHaRM provides guidance to improve the quality of harms assessment and reporting immediately, while concurrently providing a framework for future refinement. Future directions include, but are not limited to, standardising exercise-specific nomenclature and methods of assessing causality

Weekly observations of online survey metadata obtained through home computer use allow for detection of changes in everyday cognition before transition to mild cognitive impairment

IntroductionSubtle changes in instrumental activities of daily living often accompany the onset of mild cognitive impairment (MCI) but are difficult to measure using conventional tests.MethodsWeekly online survey metadata metrics, annual neuropsychological tests, and an instrumental activity of daily living questionnaire were examined in 110 healthy older adults with intact cognition (mean age = 85 years) followed up for up to 3.6 years; 29 transitioned to MCI during study follow‐up.ResultsIn the baseline period, incident MCI participants completed their weekly surveys 1.4 hours later in the day than stable cognitively intact participants, P = .03, d = 0.47. Significant associations were found between earlier survey start time of day and higher memory (r = −0.34; P < .001) and visuospatial test scores (r = −0.37; P < .0001). Longitudinally, incident MCI participants showed an increase in survey completion time by 3 seconds per month for more than the year before diagnosis compared with stable cognitively intact participants (β = 0.12, SE = 0.04, t = 2.8; P = .006).DiscussionWeekly online survey metadata allowed for detection of changes in everyday cognition before transition to MCI.Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/152601/1/alzjjalz201707756.pd

Maintaining Academic Performance and Student Satisfaction during the Remote Transition of a Nursing Obstetrics Course to Online Instruction

This study explores the effect of rapidly transitioning an in-person pre-licensure nursing specialty course to remote instruction during the COVID-19 pandemic. The redesign included the following learning technologies: live and recorded whiteboard lectures with Socratic-style questioning, electronic audience response systems, remote simulations, and virtual unfolding case studies to replace didactic and clinical learning experiences. Quantitative results indicate that learning quality was sustained, with no significant difference in students’ course performance or satisfaction. These specific technologies can be utilized in any discipline-specific course during emergency remote instruction to promote essential student-to-student and faculty-to-student interactivity