Indigenous Knowledge of Hydrologic Change in the Yukon River Basin: A Case Study of Ruby, Alaska

In the Arctic and Subarctic, the contribution of Indigenous knowledge to understanding environmental change has been established over the last several decades. This paper explores the role of Indigenous knowledge of water in understanding hydrologic change within complex social-ecological systems. Observations of hydrology in the Yukon River Basin, contributed by 20 community experts from Ruby Village, Alaska, in semi-structured interviews, are compared with findings from scientific literature to illustrate the commonalities and differences. Research findings reveal the contribution of Indigenous knowledge to understandings of hydrologic change in the Yukon River and its tributaries, which includes insights regarding alterations in sediment and river ice regimes. Recommendations for future research that incorporates Indigenous knowledge of water to gain insight into hydrologic changes in the watershed include combining multiple case studies that are distributed geographically. Our findings suggest 1) that using participatory research approaches to research will help ensure that it benefits the communities whose livelihoods are affected by hydrologic changes, and 2) that a multidisciplinary approach that combines qualitative and quantitative methods from the social and biophysical sciences would be most effective to help us understand and respond to hydrologic changes.Dans l’Arctique et la région subarctique, l’apport des connaissances indigènes à l’égard de la compréhension de l’altération de l’environnement a été mis au clair au cours des dernières décennies. Cette communication explore le rôle des connaissances indigènes relativement à l’eau dans la compréhension des changements hydrologiques touchant les systèmes socioécologiques complexes. Les observations hydrologiques dans le bassin du fleuve Yukon, émanant de 20 experts communautaires de Ruby Village, en Alaska et prélevées dans le cadre d’entrevues semi-structurées, sont comparées aux constatations publiées dans des documents scientifiques pour illustrer les points communs et les différences. Les résultats de recherche révèlent l’apport des connaissances indigènes en matière de compréhension des changements hydrologiques caractérisant le fleuve Yukon et ses affluents, ce qui comprend un aperçu de l’altération des sédiments et des régimes de glaces fluviales. Les recommandations de recherches futures faisant appel aux connaissances indigènes de l’eau afin de mieux comprendre les changements hydrologiques du bassin hydrographique préconisent le fait de combiner de nombreuses études de cas géographiquement réparties. Nos constatations suggèrent 1) que le recours à des méthodes de recherche participative aidera à faire en sorte que les collectivités dont le mode de vie est touché par les changements hydrologiques bénéficient des travaux de recherche, et 2) qu’une approche multidisciplinaire dans les domaines des sciences sociales et biophysiques faisant appel à la fois à des méthodes qualitatives et à des méthodes quantitatives s’avérerait plus efficace, et nous aiderait à comprendre les changements hydrologiques puis à y réagir

Water Governance: Retheorizing Politics

This republished Special Issue highlights recent and emergent concepts and approaches to water governance that re-centers the political in relation to water-related decision making, use, and management. To do so at once is to focus on diverse ontologies, meanings and values of water, and related contestations regarding its use, or its importance for livelihoods, identity, or place-making. Building on insights from science and technology studies, feminist, and postcolonial approaches, we engage broadly with the ways that water-related decision making is often depoliticized and evacuated of political content or meaning—and to what effect. Key themes that emerged from the contributions include the politics of water infrastructure and insecurity; participatory politics and multi-scalar governance dynamics; politics related to emergent technologies of water (bottled or packaged water, and water desalination); and Indigenous water governance

Correlating femoral shape with patellar kinematics in patients with patellofemoral pain

The etiology of patellofemoral pain is likely related to pathological femoral shape and soft-tissue restraints imbalance. These factors may result in various maltracking patterns in patients with patellofemoral pain. Thus, we hypothesized that femoral shape influences patellofemoral kinematics, but that this influence differs between kinematically unique subgroups of patients with patellofemoral pain. 3D MRIs of 30 knees with patellofemoral pain and maltracking (“maltrackers”) and 33 knees of asymptomatic subjects were evaluated, retrospectively. Dynamic MRI was acquired during a flexion-extension task. Maltrackers were divided into two subgroups (nonlateral and lateral maltrackers) based on previously defined kinematic criteria. Nine measures of femoral trochlear shape and two measures of patellar shape were quantified. These measures were correlated with patellofemoral kinematics. Differences were found in femoral shape between the maltracking and asymptomatic cohorts. Femoral shape parameters were associated with patellar kinematics in patients with patellofemoral pain and maltracking, but the correlations were unique across subgroups within this population. The ability to better categorize patients with patellofemoral pain will likely improve treatment by providing a more specific etiology of maltracking in individual patients. © 2010 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 28:865–872, 2010Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/75790/1/21101_ftp.pd

Performance Evaluation of the ISS Water Processor Multifiltration Beds

The ISS Water Processor Assembly (WPA) produces potable water from a waste stream containing humidity condensate and urine distillate. The primary treatment process is achieved in the Multifiltration Bed, which includes adsorbent media and ion exchange resin for the removal of dissolved organic and inorganic contaminants. The first Multifiltration Bed was replaced on ISS in July 2010 after initial indication of inorganic breakthrough. This bed was returned to ground in July 2011 for an engineering investigation. The water resident in the bed was analyzed for various parameters to evaluate adsorbent loading, performance of the ion exchange resin, microbial activity, and generation of leachates from the ion exchange resin. Portions of the adsorbent media and ion exchange resin were sampled and subsequently desorbed to identify the primary contaminants removed at various points in the bed. In addition, an unused Multifiltration Bed was evaluated after two years in storage to assess the generation of leachates during storage. This assessment was performed to evaluate the possibility that these leachates are impacting performance of the Catalytic Reactor located downstream of the Multifiltration Bed. The results of these investigations and implications to the operation of the WPA on ISS are documented in this paper

Ablation in pancreatic cancer: Past, present and future

The insidious onset and aggressive nature of pancreatic cancer contributes to the poor treatment response and high mortality of this devastating disease. While surgery, chemotherapy and radiation have contributed to improvements in overall survival, roughly 90% of those afflicted by this disease will die within 5 years of diagnosis. The developed ablative locoregional treatment modalities have demonstrated promise in terms of overall survival and quality of life. In this review, we discuss some of the recent studies demonstrating the safety and efficacy of ablative treatments in patients with locally advanced pancreatic cancer

Neogenin and RGMa control neural tube closure and neuroepithelial morphology by regulating cell polarity

In humans, neural tube closure defects occur in 1: 1000 pregnancies. The design of new strategies for the prevention of such common defects would benefit from an improved understanding of the molecular events underlying neurulation. Neural fold elevation is a key morphological process that acts during neurulation to drive neural tube closure. However, to date, the molecular pathways underpinning neural fold elevation have not been elucidated. Here, we use morpholino knock-down technology to demonstrate that Repulsive Guidance Molecule (RGMa)-Neogenin interactions are essential for effective neural fold elevation during Xenopus neurulation and that loss of these molecules results in disrupted neural tube closure. We demonstrate that Neogenin and RGMa are required for establishing the morphology of deep layer cells in the neural plate throughout neurulation. We also show that loss of Neogenin severely disrupts the microtubule network within the deep layer cells suggesting that Neogenin-dependent microtubule organization within the deep cells is essential for radial intercalation with the overlying superficial cell layer, thereby driving neural fold elevation. In addition, we show that sustained Neogenin activity is also necessary for the establishment of the apicobasally polarized pseudostratified neuroepithelium of the neural tube. Therefore, our study identifies a novel signaling pathway essential for radial intercalation and epithelialization during neural fold elevation and neural tube morphogenesis. Copyright ©2008 Society for Neuroscienc

Updated Performance Evaluation of the ISS Water Processor Multifiltration Beds

The ISS Water Processor Assembly (WPA) produces potable water from a waste stream containing humidity condensate and urine distillate. The primary treatment process is achieved in the Multifiltration Beds, which include adsorbent media and ion exchange resin for the removal of dissolved organic and inorganic contaminants. Two Multifiltration Beds (MF Beds) were replaced on ISS in July 2010 after initial indication of inorganic breakthrough of the first bed and an increasing Total Organic Carbon (TOC) trend in the product water. The first bed was sampled and analyzed Sept 2011 through March 2012. The second MF Bed was sampled and analyzed June 2012 through August 2012. The water resident in the both beds was analyzed for various parameters to evaluate adsorbent loading, performance of the ion exchange resin, microbial activity, and generation of leachates from the ion exchange resin. Portions of the adsorbent media and ion exchange resin were sampled and subsequently desorbed to identify the primary contaminants removed at various points in the bed in addition to microbial analysis. Analysis of the second bed will be compared to results from the first bed to provide a comprehensive overview of how the Multifiltration Beds function on orbit. New data from the second bed supplements the analysis of the first bed (previously reported) and gives a more complete picture of breakthrough compounds, resin breakdown products, microbial activity, and difficult to remove compounds. The results of these investigations and implications to the operation of the WPA on ISS are documented in this paper

Antidepressants and inflammatory bowel disease: a systematic review

BACKGROUND: A number of studies have suggested a link between the patient's psyche and the course of inflammatory bowel disease (IBD). Although pharmacotherapy with antidepressants has not been widely explored, some investigators have proposed that treating psychological co-morbidities with antidepressants may help to control disease activity. To date a systematic analysis of the available studies assessing the efficacy of antidepressants for the control of somatic symptoms in IBD patients has not been performed. METHODS: We searched electronic databases, without any language restriction. All relevant papers issued after 1990 were examined. RESULTS: 12 relevant publications were identified. All of them referred to non-randomised studies. Antidepressants reported in these publications included paroxetine, bupropion, amitriptyline, phenelzine, and mirtazapine. In 10 articles, paroxetine, bupropion, and phenelzine were suggested to be effective for treating both psychological and somatic symptoms in patients suffering from IBD. Amitriptyline was found ineffective for treating somatic symptoms of IBD. Mirtazapine was not recommended for IBD patients. CONCLUSION: Although most of reviewed papers suggest a beneficial effect of treatment with antidepressants in patients with IBD, due to the lack of reliable data, it is impossible to judge the efficacy of antidepressants in IBD. Properly designed trials are justified and needed based upon the available uncontrolled data

Myc Cooperates with Ras by Programming Inflammation and Immune Suppression.

The two oncogenes KRas and Myc cooperate to drive tumorigenesis, but the mechanism underlying this remains unclear. In a mouse lung model of KRasG12D-driven adenomas, we find that co-activation of Myc drives the immediate transition to highly proliferative and invasive adenocarcinomas marked by highly inflammatory, angiogenic, and immune-suppressed stroma. We identify epithelial-derived signaling molecules CCL9 and IL-23 as the principal instructing signals for stromal reprogramming. CCL9 mediates recruitment of macrophages, angiogenesis, and PD-L1-dependent expulsion of T and B cells. IL-23 orchestrates exclusion of adaptive T and B cells and innate immune NK cells. Co-blockade of both CCL9 and IL-23 abrogates Myc-induced tumor progression. Subsequent deactivation of Myc in established adenocarcinomas triggers immediate reversal of all stromal changes and tumor regression, which are independent of CD4+CD8+ T cells but substantially dependent on returning NK cells. We show that Myc extensively programs an immune suppressive stroma that is obligatory for tumor progression