Is Personality Key? Persuasive Effects of Prior Attitudes and Personality in Political Microtargeting

Messages that are designed to match a recipient’s personality, as enabled by microtargeting, have been found to influence political reasoning and even voting intentions. We extended these findings by adding prior attitudes to a microtargeting setting. Specifically, we examined what role different microtargeting approaches play in political reasoning by conducting an online experiment with a 2 (extraverted vs. introverted communication) × 2 (attitude-congruent vs. attitude-incongruent statement) between-subject design (N = 368). In line with the assumptions of the theory of motivated reasoning, attitude position matching emerged as an effective microtargeting strategy, and attitude strength moderated the effect of attitude congruency on recipients’ evaluations of political ads. While extraverted messages had no direct effect, that was unrelated to attitude congruency, recipients’ level of extraversion moderated the effect of extraverted communication on their evaluation of an ad. Interestingly, the intention to vote was significantly higher when an attitude-incongruent statement was phrased in an introverted rather than an extraverted manner, suggesting that information that challenges prior attitudes might be more persuasive when it is delivered in a more temperate way. In sum, the study indicates that matching message with personality alone might not be the most effective microtargeting approach within democratic societies

Impact of elosulfase alfa in patients with morquio A syndrome who have limited ambulation: An open-label, phase 2 study.

Efficacy and safety of elosulfase alfa enzyme replacement therapy (ERT) were assessed in an open-label, phase 2, multi-national study in Morquio A patients aged ≥5 years unable to walk ≥30 meters in the 6-min walk test. Patients received elosulfase alfa 2.0 mg/kg/week intravenously for 48 weeks. Efficacy measures were functional dexterity, pinch/grip strength, mobility in a modified timed 25-foot walk, pain, quality of life, respiratory function, and urine keratan sulfate (KS). Safety/tolerability was also assessed. Fifteen patients received elosulfase alfa, three patients discontinued ERT due to adverse events (two were grade 3 drug-related adverse events, the other was not drug-related), and two patients missed >20% of planned infusions; 10 completed treatment through 48 weeks and received ≥80% of planned infusions (Modified Per Protocol [MPP] population). The study population had more advanced disease than that enrolled in other trials. From baseline to week 48, MPP data showed biochemical efficacy (urine KS decreased 52.4%). The remaining efficacy results were highly variable due to challenges in test execution because of severe skeletal and joint abnormalities, small sample sizes, and clinical heterogeneity among patients. Eight patients showed improvements in one or more outcome measures; several patients indicated improvements not captured by the study assessments (e.g., increased energy, functional ability). The nature of adverse events was similar to other elosulfase alfa studies. This study illustrates the considerable challenges in objectively measuring impact of ERT in very disabled Morquio A patients and highlights the need to examine results on an individual basis. © 2016 The Authors. American Journal of Medical Genetics Part A Published by Wiley Periodicals, Inc

The Sacrifice of Darkness

A review of the 2020 book by Roxane Gay, Tracy Lynne Oliver, and Rebecca Kirby, "The Sacrifice of Darkness," for inclusion in ARLIS/NA's 2020 Notable Graphic Novels Review

Clinical situations for which 3D printing is considered an appropriate representation or extension of data contained in a medical imaging examination: Neurosurgical and otolaryngologic conditions

BACKGROUND: Medical three dimensional (3D) printing is performed for neurosurgical and otolaryngologic conditions, but without evidence-based guidance on clinical appropriateness. A writing group composed of the Radiological Society of North America (RSNA) Special Interest Group on 3D Printing (SIG) provides appropriateness recommendations for neurologic 3D printing conditions. METHODS: A structured literature search was conducted to identify all relevant articles using 3D printing technology associated with neurologic and otolaryngologic conditions. Each study was vetted by the authors and strength of evidence was assessed according to published guidelines. RESULTS: Evidence-based recommendations for when 3D printing is appropriate are provided for diseases of the calvaria and skull base, brain tumors and cerebrovascular disease. Recommendations are provided in accordance with strength of evidence of publications corresponding to each neurologic condition combined with expert opinion from members of the 3D printing SIG. CONCLUSIONS: This consensus guidance document, created by the members of the 3D printing SIG, provides a reference for clinical standards of 3D printing for neurologic conditions

ECG measurement parameters of athletes are reliable when made with a smartphone based ECG device

Pre-participation cardiac screening including electrocardiogram (ECG) is a subject of controversy among sports medicine practitioners. Opponents of pre-participation ECG screen site concerns regarding the cost and accuracy of the testing. Recently, a single lead ECG accessory has become available for use with smartphones. The purpose of this study was to evaluate the between and within rater validity and reliability of the Kardia device in recording the ECG parameters rate, rhythm, and PR, QRS, and QT intervals. The ECG parameter made with the smartphone were also compared to same measures made using a 12 lead electrocardiograph. This investigation used a repeated measures cross-sectional design. The investigation was conducted in 2 separate phases using separate participant samples. Phase 1 (N=10) was used to determine the within rater reliability with the Kardia device. Phase 2 (N=12) was used to determine the reliability between the Kardia device and the 12 lead electrocardiograph. The between rater and between device reliability for the rate, QT interval and QRS duration parameters ranged good to very good (ICC = 0.667 – 0.981). The current investigation showed that the reliability of the ECG parameters measured using the smartphone technology ranged from good to very good. This paper serves as support for a technological advancement that will help advance the debate on the utility of ECG testing as part of the athletic pre-participation physical

Fetuin-B, a potential link of liver-adipose tissue cross talk during diet-induced weight loss–weight maintenance

BACKGROUND/OBJECTIVES: Numerous hepatokines are involved in inter-organ cross talk regulating tissue-specific insulin sensitivity. Adipose tissue lipolysis represents a crucial element of adipose insulin sensitivity and is substantially involved in long-term body weight regulation after dietary weight loss. Thus, we aimed to analyze the impact of the hepatokine Fetuin-B in the context of weight loss induced short- and long-term modulation of adipose insulin sensitivity. SUBJECTS/METHODS: 143 subjects (age > 18; BMI >= 27 kg/m(2)) were analyzed before (T-3) and after (T0) a standardized 12-week dietary weight reduction program. Afterward, subjects were randomized to a 12-month lifestyle intervention or a control group. After 12 months (T12) no further intervention was performed until 6 months later (T18) (Maintain-Adults trial). Tissue-specific insulin sensitivity was estimated by HOMA-IR (predominantly liver), ISIClamp (predominantly skeletal muscle), and free fatty acid suppression during hyperinsulinemic-euglycemic clamp (FFA(Supp)) (predominantly adipose tissue). Fetuin-B was measured at all concomitant time points. RESULTS: Circulating Fetuin-B levels correlated significantly with estimates of obesity, hepatic steatosis as well as HOMA-IR, ISIClamp, FFA(Supp) at baseline. Fetuin-B decreased during dietary weight loss (4.2 (3.5-4.9) vs. 3.8 (3.2-4.6) mu g/ml; p = 2.1 x 10(-5)). This change was associated with concomitant improvement of HOMA-IR (r = 0.222; p = 0.008) and FFA(Supp) (r = -0.210; p = 0.013), suggesting a particular relationship to hepatic and adipose tissue insulin sensitivity. Weight loss induced improvements of insulin resistance were almost completely preserved until months 12 and 18 and most interestingly, the short and long-term improvement of FFA(Supp) was partially predicted by baseline level of Fetuin-B. CONCLUSIONS: Our data suggest that Fetuin-B might be a potential mediator of liver-adipose cross talk involved in short- and long-term regulation of adipose insulin sensitivity, especially in the context of diet-induced weight changes

Modern slavery, environmental degradation and climate change: present and future pathways for addressing the nexus

Roundtable Report based on the findings of an event hosted by the Rights Lab, Delta 8.7 and funded by WWF U.S. to support the development of a collaborative action plan to support efforts for the antislavery and environmental communities to work together to tackle the modern slavery-environmental degradation-climate change nexus

Evolution of Gas Flows along the Starburst to Post-Starburst to Quiescent Galaxy Sequence

We measure velocity offsets in the NaI $\lambda\lambda5890, 5896$ (Na D) interstellar medium absorption lines to track how neutral galactic winds change as their host galaxies evolve. Our sample of $\sim$80,000 SDSS spectra at $0.010 < z < 0.325$ includes starburst, post-starburst, and quiescent galaxies, forming an evolutionary sequence of declining star formation rate (SFR). We detect bulk flows across this sequence, mostly at higher host stellar masses($log(M_{\star}/M_{\odot})>10$). Along this sequence, the fraction of outflows decreases ($76\pm2\%$ to $65\pm4\%$ to a 3$\sigma$ upper limit of $34\%$), and the mean velocity offset changes from outflowing to inflowing ($-84.6\pm5.9$ to $-71.6\pm11.4$ to $76.6\pm2.3\,km\,s^{-1}$). Even within the post-starburst sample, wind speed decreases with time elapsed since the starburst ended. These results reveal that outflows diminish as galaxies age. For post-starbursts, there is evidence for an AGN contribution, especially to the speediest outflows: 1) SFR declines faster in time than outflow velocity, a decoupling arguing against massive stellar feedback; 2) of the few outflows strong enough to escape the interstellar medium (9/105), three of the four hosts with measured emission lines are Seyfert galaxies. For disky starburst galaxies, however, the trends suggest flows out of the stellar disk plane (with outflow 1/2-opening angle $> 45$ degree) instead of from the nucleus: the wind velocity decreases as the disk becomes more edge-on, and the outflow fraction, constant at $\sim$90$\%$ for disk inclinations $i<45$ degree, steadily decreases from $\sim$90$$ to 20$\%$ for $i>45$ degree.Comment: 22 pages, 19 figures, accepted for publication in MNRA

Medulloblastoma has a global impact on health related quality of life: Findings from an international cohort.

BackgroundUnderstanding the global impact of medulloblastoma on health related quality of life (HRQL) is critical to characterizing the broad impact of this disease and realizing the benefits of modern treatments. We evaluated HRQL in an international cohort of pediatric medulloblastoma patients.MethodsSeventy-six patients were selected from 10 sites across North America, Europe, and Asia, who participated in the Medulloblastoma Advanced Genomics International Consortium (MAGIC). The Health Utilities Index (HUI) was administered to patients and/or parents at each site. Responses were used to determine overall HRQL and attributes (ie specific subdomains). The impact of various demographic and medical variables on HRQL was considered-including molecular subgroup.ResultsThe majority of patients reported having moderate or severe overall burden of morbidity for both the HUI2 and HUI3 (HUI2&nbsp;=&nbsp;60%; HUI3&nbsp;=&nbsp;72.1%) when proxy-assessed. Self-care in the HUI2 was rated as higher (ie better outcome) for patients from Western versus Eastern sites, P&nbsp;=&nbsp;.02. Patients with nonmetastatic status had higher values (ie better outcomes) for the HUI3 hearing, HUI3 pain, and HUI2 pain, all P&nbsp;&lt;&nbsp;.05. Patients treated with a gross total resection also&nbsp;had better outcomes for the HUI3 hearing (P&nbsp;=&nbsp;.04). However, those who underwent a gross total resection reported&nbsp;having worse outcomes on the HUI3 vision (P&nbsp;=&nbsp;.02). No differences in HRQL were evident as a function of subgroup.ConclusionsBy examining an international sample of survivors, we characterized the worldwide impact of medulloblastoma. This is a critical first step in developing global standards for evaluating long-term outcomes