Comprendre la victoire du 'Non' : proximité partisane, conjoncture et attitude à l’égard de l’Europe

Le 29 mai (2005) a rejoint le 21 avril (2002) au rang des scrutins qui ont fait date. L'ampleur de la victoire d'un « Non » (54,67%), soutenue par une participation élevée (69,37%), fait du résultat du référendum de ratification du Traité constitutionnel européen un événement comparable à l'élimination du candidat socialiste lors du premier tour d'une élection présidentielle. [Premier paragraphe

Le projet Demopædia: questions terminologiques liées à l’élaboration du Dictionnaire démographique multilingue

The aim of this paper is to present the terminological issues that have accompanied the process of translation and harmonization of the Italian edition of the multilingual demographic Dictionary Demopædia started in 2007 and ended in 2012. After presenting a brief history of the demographic multilingual dictionaries, the authors describe the computerization process and harmonization of dictionaries, in particular of the Italian edition

Loss of IL-10 secretion by regulatory B lymphocytes in multiple sclerosis patients

International audienc

Haut parleur tout aimant guidé sur joint ferrofluide : caractérisation dynamique du guidage

Une étude expérimentale sur le comportement visqueux de ferrofluides, au sein d'une goutte insérée entre deux plans parallèles, en condition de cisaillement oscillatoire et sous champ magnétique homogène et stationnaire, permet d'alimenter un modèle pour les pertes d'un haut-parleur tout aimant guidé sur joint ferrofluide. Ces joints sont localisés dans les zones de fort gradient de champs magnétique. Le modèle de perte, fonction du volume, de la viscosité et de la saturation magnétique du ferrofluide, est alors validé par confrontation avec une expérience

Natalizumab alters the TCR repertoire after one year of treatment in four MS patients

International audiencen.

‘Citizens’ Attitudes Under Covid19’, a cross-country panel survey of public opinion in 11 advanced democracies

This article introduces data collected in the Citizens’ Attitudes Under Covid-19 Project (CAUCP), which surveyed public opinion throughout the Covid-19 pandemic in 11 democracies between March and December 2020. In this paper, we present a unique cross-country panel survey of citizens’ attitudes and behaviors during a worldwide unprecedented health, governance, and economic crisis. This dataset investigates the behavioral and attitudinal consequences of multifaceted Covid19 crisis across time and contexts. In this paper, we describe the design of the CAUCP and the descriptive features of the dataset; we also present promising research prospects

Human granzyme B regulatory B cells prevent effector CD4+CD25- T cell proliferation through a mechanism dependent from lymphotoxin alpha

IntroductionHuman Granzyme B (GZMB) regulatory B cells (Bregs) have suppressive properties on CD4+ effector T cells by a mechanism partially dependent on GZMB. Moreover, these cells may be easily induced in vitro making them interesting for cell therapy.MethodsWe characterized this population of in vitro induced GZMB+Bregs using single cell transcriptomics. To investigate their regulatory properties, Bregs or total B cells were also co-cultured with T cells and scRNAseq was used to identify receptor ligand interactions and to reveal gene expression changes in the T cells.ResultsWe find that Bregs exhibit a unique set of 149 genes differentially expressed and which are implicated in proliferation, apoptosis, metabolism, and altered antigen presentation capacity consistent with their differentiated B cells profile. Notably, Bregs induced a strong inhibition of T cell genes associated to proliferation, activation, inflammation and apoptosis compared to total B cells. We identified and validated 5 receptor/ligand interactions between Bregs and T cells. Functional analysis using specific inhibitors was used to test their suppressive properties and we identified Lymphotoxin alpha (LTA) as a new and potent Breg ligand implicated in Breg suppressive properties.DiscussionWe report for the first time for a role of LTA in GZMB+Bregs as an enhancer of GZMB expression, and involved in the suppressive properties of GZMB+Bregs in human. The exact mechanism of LTA/GZMB function in this specific subset of Bregs remains to be determined