Galaxy Clusters in the Line of Sight to Background Quasars: II. Environmental effects on the sizes of baryonic halo sizes

Based on recent results on the frequency of MgII absorption line systems in the "QSO behind RCS clusters" survey (QbC), we analyse the effects of the cluster environment on the sizes of baryonic haloes around galaxies. We use two independent models, i) an empirical halo occupation model which fits current measurements of the clustering and luminosity function of galaxies at low and high redshifts, and ii) the GALFORM semi-analytic model of galaxy formation, which follows the evolution of the galaxy population from first principles, adjusted to match the statistics of low and high redshift galaxies. In both models we constrain the MgII halo sizes of field and cluster galaxies using observational results on the observed MgII statistics. Our results for the field are in good agreement with previous works, indicating a typical \mgii\ halo size of $r_MgII ~ 50h_71^-1kpc in the semi-analytic model, and slightly lower in the halo occupation number approach. For the cluster environment, we find that both models require a median MgII halo size of r_MgII< 10h_71^-1kpc in order to reproduce the observed statistics on absorption line systems in clusters of galaxies. Based on the Chen & Tinker (2008) result that stronger systems occur closer to the MgII halo centre, we find that strong absorption systems in clusters of galaxies occur at roughly a fixed fraction of the cold-warm halo size out to 1h_71^-1Mpc from the cluster centres. In contrast, weaker absorption systems appear to occur at progressively shorter relative fractions of this halo as the distance to the cluster centre decreases.Comment: 12 pages, 8 figures, accepted for publication in MNRA

Evolving trends in the management of acute appendicitis during COVID-19 waves. The ACIE appy II study

Background: In 2020, ACIE Appy study showed that COVID-19 pandemic heavily affected the management of patients with acute appendicitis (AA) worldwide, with an increased rate of non-operative management (NOM) strategies and a trend toward open surgery due to concern of virus transmission by laparoscopy and controversial recommendations on this issue. The aim of this study was to survey again the same group of surgeons to assess if any difference in management attitudes of AA had occurred in the later stages of the outbreak. Methods: From August 15 to September 30, 2021, an online questionnaire was sent to all 709 participants of the ACIE Appy study. The questionnaire included questions on personal protective equipment (PPE), local policies and screening for SARS-CoV-2 infection, NOM, surgical approach and disease presentations in 2021. The results were compared with the results from the previous study. Results: A total of 476 answers were collected (response rate 67.1%). Screening policies were significatively improved with most patients screened regardless of symptoms (89.5% vs. 37.4%) with PCR and antigenic test as the preferred test (74.1% vs. 26.3%). More patients tested positive before surgery and commercial systems were the preferred ones to filter smoke plumes during laparoscopy. Laparoscopic appendicectomy was the first option in the treatment of AA, with a declined use of NOM. Conclusion: Management of AA has improved in the last waves of pandemic. Increased evidence regarding SARS-COV-2 infection along with a timely healthcare systems response has been translated into tailored attitudes and a better care for patients with AA worldwide

The ROCK inhibitor fasudil prevents chronic restraint stress-induced depressive-like behaviors and dendritic spine loss in rat hippocampus

Background: Dendritic arbor simplification and dendritic spine loss in the hippocampus, a limbic structure implicated in mood disorders, are assumed to contribute to symptoms of depression. These morphological changes imply modifications in dendritic cytoskeleton. Rho GTPases are regulators of actin dynamics through their effector Rho kinase. We have reported that chronic stress promotes depressive-like behaviors in rats along with dendritic spine loss in apical dendrites of hippocampal pyramidal neurons, changes associated with Rho kinase activation. The present study proposes that the Rho kinase inhibitor Fasudil may prevent the stress-induced behavior and dendritic spine loss. Methods: Adult male Sprague-Dawley rats were injected with saline or Fasudil (i.p., 10 mg/kg) starting 4 days prior to and maintained during the restraint stress procedure (2.5 h/d for 14 days). Nonstressed control animals were injected with saline or Fasudil for 18 days. At 24 hours after treatment, forced swimming test, Golgi-staining, and immuno-western blot were performed. Results: Fasudil prevented stress-induced immobility observed in the forced swimming test. On the other hand, Fasudiltreated control animals showed behavioral patterns similar to those of saline-treated controls. Furthermore, we observed that stress induced an increase in the phosphorylation of MYPT1 in the hippocampus, an exclusive target of Rho kinase. This change was accompanied by dendritic spine loss of apical dendrites of pyramidal hippocampal neurons. Interestingly, increased pMYPT1 levels and spine loss were both prevented by Fasudil administration. Conclusion: Our findings suggest that Fasudil may prevent the development of abnormal behavior and spine loss induced by chronic stress by blocking Rho kinase activity.National Commission for Scientific and Technological Research of Chile FONDECYT 1120528 FONDEQUIP EQM120114 21120711 Fondo Central de Investigación, Universidad de Chile ENL025/1

The host galaxies and progenitors of fast radio bursts localized with the Australian square kilometre Array Pathfinder

The Australian SKA Pathfinder (ASKAP) telescope has started to localize fast radio bursts (FRBs) to arcsecond accuracy from the detection of a single pulse, allowing their host galaxies to be reliably identified. We discuss the global properties of the host galaxies of the first four FRBs localized by ASKAP, which lie in the redshift range 0.11 z < 0.48. All four are massive galaxies (log(M-*/M) similar to 9.4-10.4) with modest star formation rates of up to 2 M yr(-1)-very different to the host galaxy of the first repeating FRB 121102, which is a dwarf galaxy with a high specific star formation rate. The FRBs localized by ASKAP typically lie in the outskirts of their host galaxies, which appears to rule out FRB progenitor models that invoke active galactic nuclei or free-floating cosmic strings. The stellar population seen in these host galaxies also disfavors models in which all FRBs arise from young magnetars produced by superluminous supernovae, as proposed for the progenitor of FRB 121102. A range of other progenitor models (including compact-object mergers and magnetars arising from normal core-collapse supernovae) remain plausible.European Southern Observatory 0102.A-0450(A) 0103.A-0101(B) Australian Research Council DP180100857 Australian Research Council FT150100415 Australian Research Council FL150100148 CE170100004 PUCV/VRIEA project 039.395/2019 National Science Foundation (NSF) AST-1911140 Australian Government Australian Government Department of Industry, Innovation and Science Government of Western Australia Science and Industry Endowment Fund W.M. Keck Foundation Las Campanas Observatory, Chile CN2019A-36 LCOGT network CN2019A-39/CLN2019A-002 CN2019B-93/CLN2019B-001 Gemini Observatory GS-2018B-Q-133 UCh/VID-ENL18/18 FONDECYT 119123

Global attitudes in the management of acute appendicitis during COVID-19 pandemic: ACIE Appy Study

Background: Surgical strategies are being adapted to face the COVID-19 pandemic. Recommendations on the management of acute appendicitis have been based on expert opinion, but very little evidence is available. This study addressed that dearth with a snapshot of worldwide approaches to appendicitis. Methods: The Association of Italian Surgeons in Europe designed an online survey to assess the current attitude of surgeons globally regarding the management of patients with acute appendicitis during the pandemic. Questions were divided into baseline information, hospital organization and screening, personal protective equipment, management and surgical approach, and patient presentation before versus during the pandemic. Results: Of 744 answers, 709 (from 66 countries) were complete and were included in the analysis. Most hospitals were treating both patients with and those without COVID. There was variation in screening indications and modality used, with chest X-ray plus molecular testing (PCR) being the commonest (19\ub78 per cent). Conservative management of complicated and uncomplicated appendicitis was used by 6\ub76 and 2\ub74 per cent respectively before, but 23\ub77 and 5\ub73 per cent, during the pandemic (both P < 0\ub7001). One-third changed their approach from laparoscopic to open surgery owing to the popular (but evidence-lacking) advice from expert groups during the initial phase of the pandemic. No agreement on how to filter surgical smoke plume during laparoscopy was identified. There was an overall reduction in the number of patients admitted with appendicitis and one-third felt that patients who did present had more severe appendicitis than they usually observe. Conclusion: Conservative management of mild appendicitis has been possible during the pandemic. The fact that some surgeons switched to open appendicectomy may reflect the poor guidelines that emanated in the early phase of SARS-CoV-2

Evolving trends in the management of acute appendicitis during COVID-19 waves. The ACIE appy II study (vol 46, pg 2021, 2022)

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