Getting Out to Work Merseyside: A Social Return On Investment Analysis

This report by the New Economics Foundation (NEF) details the social outcomes and financial impacts of Tomorrow's People's Getting Out to Work (GOTW) initiative in Merseyside, which aims to provide support and advocacy to ex-offenders in gaining access to long-term, sustainable employment. It includes the findings of the evaluation and a discussion about the effectiveness of the initiative relative to its objectives and to national averages. The social and economic returns generated by GOTW are also estimated, using NEF's approach to Social Return on Investment (SROI) analysis. Finally, six recommendations based on the evaluation's conclusions are explained

Role of the heat shock transcription factor, Hsf1, in a major fungal pathogen that is obligately associated with warm-blooded animals

Peer reviewedPublisher PD

Developmental Regulation of an Adhesin Gene during Cellular Morphogenesis in the Fungal Pathogen Candida albicans

Peer reviewedPublisher PD

A longitudinal assessment of the responsiveness of the ICECAP-A in a randomised controlled trial of a knee pain intervention

PURPOSE: The ICECAP-A is a simple measure of capability well-being for use with the adult population. The descriptive system is made up of five key attributes: Stability, Attachment, Autonomy, Achievement and Enjoyment. Studies have begun to assess the psychometric properties of the measure, including the construct and content validity and feasibility for use. This is the first study to use longitudinal data to assess the responsiveness of the measure. METHODS: This responsiveness study was completed alongside a randomised controlled trial comparing three physiotherapy-led exercise interventions for older adults with knee pain attributable to osteoarthritis. Anchor-based methodologies were used to explore the relationship between change over time in ICECAP-A score (the target measure) and change over time in another measure (the anchor). Analyses were completed using the non-value-weighted and value-weighted ICECAP-A scores. The EQ-5D-3L was used as a comparator measure to contextualise change in the ICECAP-A. Effect sizes, standardised response means and t tests were used to quantify responsiveness. RESULTS: Small changes in the ICECAP-A scores were seen in response to underlying changes in patients' health-related quality of life, anxiety and depression. Non-weighted scores were slightly more responsive than value-weighted scores. ICECAP-A change was of comparable size to change in the EQ-5D-3L reference measure. CONCLUSION: This first analysis of the responsiveness using longitudinal data provides some positive evidence for the responsiveness of the ICECAP-A measure. There is a need for further research in those with low health and capability, and experiencing larger underlying changes in quality of life

An analysis of the complementarity of ICECAP-A and EQ-5D-3L in an adult population of patients with knee pain

BACKGROUND: The ICECAP measures potentially offer a broader assessment of quality of life and well-being, in comparison to measures routinely used in economic evaluation, such as the EQ-5D-3 L. This broader assessment may allow measurement of the full effects of an intervention or treatment. Previous research has indicated that the ICECAP-O (for older people) and EQ-5D-3 L measure provide complementary information. This paper aims to determine similar information for the ICECAP-A (for the entire adult population) in terms of whether the measure is a substitute or complement to the EQ-5D-3 L. METHODS: Data from the BEEP trial - a multi-centre, pragmatic, randomised controlled trial - were used. Spearman rank correlations and exploratory factor analytic methods were used to assess whether ICECAP-A and EQ-5D-3 L are measuring the same, or different, constructs. RESULTS: A correlation of 0.49 (p < 0.01) was found between the ICECAP-A tariff score and the EQ-5D-3 L index. Using the pooled items of the EQ-5D-3 L and the ICECAP-A a two factor solution was optimal, with the majority of EQ-5D-3 L items loading onto one factor and the majority of ICECAP-A items onto another. CONCLUSION: The results presented in this paper indicate that ICECAP-A and EQ-5D-3 L are measuring two different constructs and provide largely different, complementary information. Results showed a similarity to results presented by Davis et al. using the ICECAP-O. TRIAL REGISTRATION: ISRCTN 93634563

The voices of “at risk” young people about services they received: a systematic literature review

In Australia young people who are at risk of offending have attracted much media and policy attention. In recent times, policy reform has seen increased funding for social services delivery to support young people at risk of entering, or are currently in, the juvenile justice system. However, there is limited literature that explores how young people experience services delivered to them. This article reports on a systematic literature review exploring the voices of children and youth on social service delivery for young people who have offended or are at risk of offending. The review aimed to identify English language publications in the fifteen-year period from 2004 to 2018, critique their methodological quality, and analyse and describe the findings of identified studies. Through a search of electronic social sciences databases twelve (n = 12) eligible publications were identified, including six qualitative studies, one quantitative study and five reports. The review highlighted a scarcity of research on this topic but provided evidence about how young people who are at risk of offending experienced social services, and their recommendations for effective service delivery. Implication Statement •Practitioners need to create supportive, caring and respectful environments that facilitate young people’s agency and self-determination; •Young people need information and clarification but may not ask for it; •Experiences of racism need to be acknowledged and racist attitudes actively addressed. An easy read poster has been developed on the recommendation of practice-based research partners to highlight the implications for practice

The Lighthouse Guide to Working with Young People

This Easy Read poster reports results of a systematic literature review exploring the voices of children and youth on social service delivery for young people who have offended or are at risk of offending. Through a search of electronic social sciences databases twelve (n=12) eligible publications were identified, including six qualitative studies, one quantitative study and five reports. The review highlighted a scarcity of research on this topic but provided evidence about how young people who are at risk of offending experienced social services, and their recommendations for effective service delivery. The data anaylis identified six themes:Supportive & Caring Relationships; Importance of Peers; Respectful Engagement; Dealing with Racism; Information & Clarification and Agency & Empathy. This easy read post was developed on the recommendation of practice-based research partners to highlight the implications for practice

Choices:Future trade-offs and plausible pathways

Policy development and management of deltas in the Anthropocene involves the consideration of trade-offs and the balancing of positive and negative consequences for delta functions and the societies that rely on them. This assessment outlines policy-driven and spatial trade-offs that dominate the landscape of choice. It highlights examples of such trade-offs using plausible delta futures and the governance choices associated with them. The analysis is based on modelling broad-scale processes and individual adaptive actions. It highlights how policy choices to maximise economic growth can, for example, have unforeseen consequences such as diminished well-being for some populations. Hence the chapter concludes that trade-offs are a crucial governance challenge for future sustainability of deltas

Activation of the heat shock transcription factor Hsf1 is essential for the full virulence of the fungal pathogen Candida albicans

Peer reviewedPublisher PD

Evidence that implementation intentions reduce self-harm in the community

Objectives: Implementation intentions are 'IF‐THEN' plans that encourage goal‐intended behaviour. This study was designed to test whether an intervention encouraging the formation of implementation intentions can reduce self‐harm in the community. Design: A randomized controlled design was used. Methods: At pre‐intervention, outcome variables (self‐harm in both specified and unspecified critical situations and suicidality) and potential moderators of implementation intentions (goal intention, mental imagery, and exposure to self‐harm) were measured using self‐report questionnaires. The participants (N = 469, aged 18–66 years, 86.4% female, 6.8% male and 6.7% other) were then randomized to either an experimental (implementation intention) or control task. At three‐months post‐intervention, self‐report questionnaires were used again to measure the outcome variables. Results: There were no overall differences between the conditions at post‐intervention. However, goal intention and mental imagery, but not exposure to self‐harm, moderated the effects of condition on self‐harm in specified critical situations. At high (mean + 1SD) levels of both goal intention and mental imagery, the experimental condition reported self‐harming less frequently in the situations specified in their implementation intentions. Conclusions: Implementation intentions therefore represent a useful intervention for reducing self‐harm in specified critical situations for people in the community who wish to avoid self‐harm and those who frequently experience self‐harm and suicide related mental imagery