Seizure semiology of anti‐LGI1 antibody encephalitis

Limbic encephalitis associated with anti‐LGI1 antibody (LGI1 encephalitis) presents with a variety of features, the most prominent of which include seizures and progressive disturbance of memory and behaviour. Although varied in semiology, recognition of the pattern of seizures in LGI1 encephalitis is important, as early diagnosis and definitive treatment may prevent subsequent development of cognitive impairment. We present a patient with LGI1 encephalitis and “faciobrachial dystonic seizures‐plus”, which began as classic faciobrachial dystonic seizures and progressed to focal seizures with impaired awareness, dacrystic/gelastic‐like outbursts, ictal speech, manual automatisms, and autonomic signs (tachycardia). Recognition of the broad range of seizure types associated with LGI1 encephalitis is crucial for early diagnosis and definitive treatment. [Published with video sequence on www.epilepticdisorders.com]Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/142082/1/epd212047.pd

Iwaidja Jurtbirrk songs: bringing language and music together

Song brings language and music together. Great singers are at once musi- cians and wordsmiths, who toss rhythm, melody and word against one another in complex cross-play. In this paper we outline some initial findings that are emerg- ing from our interdisciplinary study of the musical traditions of the Cobourg region of western Arnhem Land, a coastal area situated in the far north of the Australian continent 350 kilometres northeast of Darwin. We focus on a set of songs called Jurtbirrk, sung in Iwaidja, a highly endangered language, whose core speaker base is now located in the community of Minjilang on Croker Island. We bring to bear analytical methodologies from both musicology and linguistics to illuminate this hitherto undocumented genre of love songs.Volkswagen Foundation’s Documentation of Endangered Languages (DOBES) programm

Sustainability and duration of early central places in prehispanic mesoamerica.

During the last millennium BCE, central places were founded across many regions of western (non-Maya) Mesoamerica. These early central places differed in environmental location, size, layout, and the nature of their public spaces and monumental architecture. We compare a subset of these regional centers and find marked differences in their sustainability--defined as the duration of time that they remained central places in their respective regions. Early infrastructural investments, high degrees of economic interdependence and collaboration between domestic units, and collective forms of governance are found to be key factors in such sustainability.BCS-1118434 - National Science FoundationPublished versio

Neoproterozoic Stratigraphic Comparison of the Lesser Himalaya (India) and Yangtze Block (South China): Paleogeographic Implications

Recent studies of terminal Neoproterozoic rocks (ca. 590–543 Ma) in the Lesser Himalaya of northwestern India and the Yangtze block (south China) reveal remarkably similar facies assemblages and carbonate platform architecture, with distinctive karstic unconformities at comparable stratigraphic levels. These similarities suggest that south China may have been located close to northwestern India during late Neoproterozoic time, an interpretation permitted by the available, yet sparse paleomagnetic data. Additional parallels in older rocks of both blocks—similar rift-related siliciclastic-volcanic successions overlying metamorphic basement, and comparable glaciogenic intervals of possibly Sturtian and Marinoan or Varanger age—suggest that this spatial relationship may have developed earlier in the Neoproterozoic. With the exception of basal Cambrian phosphorite and comparable small shelly fossils, stratigraphic contrasts between northern India and south China and increasing biogeographic affinity between south China and northwestern Australia suggest that south China may have migrated toward northwestern Australia during the Cambrian

Increasing late stage colorectal cancer and rectal cancer mortality demonstrates the need for screening: a population based study in Ireland, 1994-2010

BACKGROUND: This paper describes trends in colorectal cancer incidence, survival and mortality from 1994 to 2010 in Ireland prior to the introduction of population-based screening. METHODS: We examined incidence (National Cancer Registry Ireland (NCRI) and mortality (Central Statistics Office) from 1994 to 2010. Age standardised rates (ASR) for incidence and mortality have been calculated, weighted by the European standard population. Annual percentage change was calculated in addition to testing for linear trends in treatment and case fraction of early and late stage disease. Relative survival was calculated considering deaths from all causes. RESULTS: The colorectal cancer ASR was 63.7 per 100,000 in males and 38.7 per 100,000 in females in 2010. There was little change in the ASR over time in either sex, or when colon and rectal cancers were considered separately; however the number of incident cancers increased significantly during 1994-2010 (1752 to 2298). The case fractions of late stage (III/IV) colon and rectal cancers rose significantly over time. One and 5 year relative survival improved for both sexes between the periods 1994-2008. Colorectal cancer mortality ASRs decreased annually from 1994-2009 by 1.8% (95% CI -2.2, -1.4). Rectal cancer mortality ASRs rose annually by 2.4% (95% CI 1.1, 3.6) and 2.8% (95% CI 1.2, 4.4) in males and females respectively. CONCLUSIONS: Increases in late-stage disease and rectal cancer mortality demonstrate an urgent need for colorectal cancer screening. However, the narrow age range at which screening is initially being rolled-out in Ireland means that the full potential for reductions in late-stage cancers and incidence and mortality are unlikely to be achieved. While it is possible that the observed increase in rectal cancer mortality may be partly an artefact of cause of death misclassification, it could also be explained by variations in treatment and adherence to best practice guidelines; further investigation is warranted