A new physical interpretation of optical and infrared variability in quasars

Changing-look quasars are a recently identified class of active galaxies in which the strong UV continuum and/or broad optical hydrogen emission lines associated with unobscured quasars either appear or disappear on timescales of months to years. The physical processes responsible for this behaviour are still debated, but changes in the black hole accretion rate or accretion disk structure appear more likely than changes in obscuration. Here we report on four epochs of spectroscopy of SDSS J110057.70-005304.5, a quasar at a redshift of $z=0.378$ whose UV continuum and broad hydrogen emission lines have faded, and then returned over the past $\approx$20 years. The change in this quasar was initially identified in the infrared, and an archival spectrum from 2010 shows an intermediate phase of the transition during which the flux below rest-frame $\approx$3400\AA\ has decreased by close to an order of magnitude. This combination is unique compared to previously published examples of changing-look quasars, and is best explained by dramatic changes in the innermost regions of the accretion disk. The optical continuum has been rising since mid-2016, leading to a prediction of a rise in hydrogen emission line flux in the next year. Increases in the infrared flux are beginning to follow, delayed by a $\sim$3 year observed timescale. If our model is confirmed, the physics of changing-look quasars are governed by processes at the innermost stable circular orbit (ISCO) around the black hole, and the structure of the innermost disk. The easily identifiable and monitored changing-look quasars would then provide a new probe and laboratory of the nuclear central engine.Comment: 13 pages, 4 figures, 3 tables. Published in MNRAS. All code and data links on GitHub, https://github.com/d80b2t/WISE_L

Obesity and Multiple Sclerosis: A Mendelian Randomization Study.

BACKGROUND: Observational studies have reported an association between obesity, as measured by elevated body mass index (BMI), in early adulthood and risk of multiple sclerosis (MS). However, bias potentially introduced by confounding and reverse causation may have influenced these findings. Therefore, we elected to perform Mendelian randomization (MR) analyses to evaluate whether genetically increased BMI is associated with an increased risk of MS. METHODS AND FINDINGS: Employing a two-sample MR approach, we used summary statistics from the Genetic Investigation of Anthropometric Traits (GIANT) consortium and the International MS Genetics Consortium (IMSGC), the largest genome-wide association studies for BMI and MS, respectively (GIANT: n = 322,105; IMSGC: n = 14,498 cases and 24,091 controls). Seventy single nucleotide polymorphisms (SNPs) were genome-wide significant (p < 5 x 10-8) for BMI in GIANT (n = 322,105) and were investigated for their association with MS risk in the IMSGC. The effect of each SNP on MS was weighted by its effect on BMI, and estimates were pooled to provide a summary measure for the effect of increased BMI upon risk of MS. Our results suggest that increased BMI influences MS susceptibility, where a 1 standard deviation increase in genetically determined BMI (kg/m2) increased odds of MS by 41% (odds ratio [OR]: 1.41, 95% CI 1.20-1.66, p = 2.7 x 10-5, I2 = 0%, 95% CI 0-29). Sensitivity analyses, including MR-Egger regression, and the weighted median approach provided no evidence of pleiotropic effects. The main study limitations are that, while these sensitivity analyses reduce the possibility that pleiotropy influenced our results, residual pleiotropy is difficult to exclude entirely. CONCLUSION: Genetically elevated BMI is associated with risk of MS, providing evidence for a causal role for obesity in MS etiology. While obesity has been associated with many late-life outcomes, these findings suggest an important consequence of childhood and/or early adulthood obesity.National Institute for Health Research Cambridge Biomedical Research CentreThis is the final version of the article. It first appeared from Public Library of Science via http://dx.doi.org/10.1371/journal.pmed.1002053

Near Infrared Spectra and Intrinsic Luminosities of Candidate Type II Quasars at 2 < z < 3.4

We present JHK near-infrared (NIR) spectroscopy of 25 candidate Type II quasars selected from the Sloan Digital Sky Survey, using Triplespec on the Apache Point Observatory 3.5m telescope, FIRE at the Magellan/Baade 6.5m telescope, and GNIRS on Gemini. At redshifts of 2 < z < 3.4, our NIR spectra probe the rest-frame optical region of these targets, which were initially selected to have strong lines of CIV and Ly alpha, with FWHM<2000 km/s from the SDSS pipeline. We use the [OIII]5007 line shape as a model for the narrow line region emission, and find that \halpha\ consistently requires a broad component with FWHMs ranging from 1000 to 7500 km/s. Interestingly, the CIV lines also require broad bases, but with considerably narrower widths of 1000 to 4500 km/s. Estimating the extinction using the Balmer decrement and also the relationship in lower-z quasars between rest equivalent width and luminosity in the [OIII] line, we find typical A_V values of 0-2 mag, which naturally explain the attenuated CIV lines relative to Halpha. We propose that our targets are moderately obscured quasars. We also describe one unusual object with three distinct velocity peaks in its [OIII] spectrum.Comment: Accepted for publication in ApJ, 18 pages, 14 figure

The first high-redshift changing-look quasars

We report on three redshift z > 2 quasars with dramatic changes in their C IV emission lines, the first sample of changing-look quasars (CLQs) at high redshift. This is also the first time the changing-look behaviour has been seen in a high-ionization emission line. SDSS J1205+3422, J1638+2827, and J2228 + 2201 show interesting behaviour in their observed optical light curves, and subsequent spectroscopy shows significant changes in the C IV broad emission line, with both line collapse and emergence being displayed on rest-frame time-scales of ∼240–1640 d. These are rapid changes, especially when considering virial black hole mass estimates of M_(BH) > 10⁹M⊙ for all three quasars. Continuum and emission line measurements from the three quasars show changes in the continuum-equivalent width plane with the CLQs seen to be on the edge of the full population distribution, and showing indications of an intrinsic Baldwin effect. We put these observations in context with recent state-change models, and note that even in their observed low-state, the C IV CLQs are generally above ∼5 per cent in Eddington luminosity

The first high-redshift changing-look quasars

We report on three redshift $z>2$ quasars with dramatic changes in their C IV emission lines, the first sample of changing-look quasars (CLQs) at high redshift. This is also the first time the changing-look behaviour has been seen in a high-ionisation emission line. SDSS J1205+3422, J1638+2827, and J2228+2201 show interesting behaviour in their observed optical light curves, and subsequent spectroscopy shows significant changes in the C IV broad emission line, with both line collapse and emergence being displayed on rest-frame timescales of $\sim$240-1640 days. These are rapid changes, especially when considering virial black hole mass estimates of $M_{\rm BH} > 10^{9} M_{\odot}$ for all three quasars. Continuum and emission line measurements from the three quasars show changes in the continuum-equivalent width plane with the CLQs seen to be on the edge of the full population distribution, and showing indications of an intrinsic Baldwin effect. We put these observations in context with recent state-change models, and note that even in their observed low-state, the C IV CLQs are generally above $\sim$5\% in Eddington luminosity.Comment: 12 pages, 7 figures, 4 tables. All data, analysis code and text are fully available at: github.com/d80b2t/CIV_CLQs. Comments, questions and suggestions welcome and encourage

Pembuatan Briket Arang Daun Kelapa Sawit (Elaeis Guineensis Jacq.) Dengan Perekat Pati Sagu (Metroxylon Sago Rott.)

Increasing need of energy and decreasing of fuel supply requires human to discover alternative energy resources. Consequently, there should be a research to discover a new renewable energy source such as palm leaves waste. Oil palm\u27s leaves (Elaeis guineensis Jacq.) are mostly the least used waste from oil palm plantation as an alternative energy resources. This research aims to discover the precise adhesive consentration rate in sago\u27s starch (Metroxylon sago Rott.) to make oil palm\u27s kernel, which are 97%:3%, 96%:4%, 95%:5%, 94%:6%, and 93%:7%. Based on analitycal result of oil palm\u27s leaves charcoal briquet research, the best quality briquet is the P1 composition which composed rate is 97%:3%, has 3,21% water content, 30,18% ashes content, 0,0022 g/s combustion rate, 20,73% evaporated substance rate, 54,46% carbon rate, and 5.114 cal/g heat value

Impact of the SPOP Mutant Subtype on the Interpretation of Clinical Parameters in Prostate Cancer.

Purpose: Molecular characterization of prostate cancer, including The Cancer Genome Atlas, has revealed distinct subtypes with underlying genomic alterations. One of these core subtypes, SPOP (speckle-type POZ protein) mutant prostate cancer, has previously only been identifiable via DNA sequencing, which has made the impact on prognosis and routinely used risk stratification parameters unclear. Methods: We have developed a novel gene expression signature, classifier (Subclass Predictor Based on Transcriptional Data), and decision tree to predict the SPOP mutant subclass from RNA gene expression data and classify common prostate cancer molecular subtypes. We then validated and further interrogated the association of prostate cancer molecular subtypes with pathologic and clinical outcomes in retrospective and prospective cohorts of 8,158 patients. Results: The subclass predictor based on transcriptional data model showed high sensitivity and specificity in multiple cohorts across both RNA sequencing and microarray gene expression platforms. We predicted approximately 8% to 9% of cases to be SPOP mutant from both retrospective and prospective cohorts. We found that the SPOP mutant subclass was associated with lower frequency of positive margins, extraprostatic extension, and seminal vesicle invasion at prostatectomy; however, SPOP mutant cancers were associated with higher pretreatment serum prostate-specific antigen (PSA). The association between SPOP mutant status and higher PSA level was validated in three independent cohorts. Despite high pretreatment PSA, the SPOP mutant subtype was associated with a favorable prognosis with improved metastasis-free survival, particularly in patients with high-risk preoperative PSA levels. Conclusion: Using a novel gene expression model and a decision tree algorithm to define prostate cancer molecular subclasses, we found that the SPOP mutant subclass is associated with higher preoperative PSA, less adverse pathologic features, and favorable prognosis. These findings suggest a paradigm in which the interpretation of common risk stratification parameters, particularly PSA, may be influenced by the underlying molecular subtype of prostate cancer

DNA methylation is associated with codon degeneracy in a species of bumblebee

Social insects display extreme phenotypic differences between sexes and castes even though the underlying genome can be almost identical. Epigenetic processes have been proposed as a possible mechanism for mediating these phenotypic differences. Using whole genome bisulfite sequencing of queens, males, and reproductive female workers we have characterised the sex- and caste-specific methylome of the bumblebee Bombus terrestris. We have identified a potential role for DNA methylation in histone modification processes which may influence sex and caste phenotypic differences. We also find differentially methylated genes generally show low levels of DNA methylation which may suggest a separate function for lowly methylated genes in mediating transcriptional plasticity, unlike highly methylated genes which are usually involved in housekeeping functions. We also examined the relationship between the underlying genome and the methylome using whole genome re-sequencing of the same queens and males. We find DNA methylation is enriched at zero-fold degenerate sites. We suggest DNA methylation may be acting as a targeted mutagen at these sites, providing substrate for selection via non-synonymous changes in the underlying genome. However, we did not see any relationship between DNA methylation and rates of positive selection in our samples. In order to fully assess a possible role for DNA methylation in adaptive processes a specifically designed study using natural population data is needed.</p