1,071 research outputs found
Development and application of optical fibre strain and pressure sensors for in-flight measurements
Fibre optic based sensors are becoming increasingly viable as replacements for traditional
flight test sensors. Here we present laboratory, wind tunnel and flight test results of fibre
Bragg gratings (FBG) used to measure surface strain and an extrinsic fibre
FabryâPerot
interferometric (EFFPI) sensor used to measure unsteady pressure. The calibrated full
scale resolution and bandwidth of the FBG and EFFPI sensors were shown to be 0.29% at
2.5 kHz up to 600 ΌΔ and 0.15% at up to 10 kHz respectively up to 400 Pa. The wind tunnel
tests, completed on a 30% scale model, allowed the EFFPI sensor to be developed before
incorporation with the FBG system into a Bulldog aerobatic light aircraft. The aircraft was
modified and certified based on Certification Standards 23 (CS-23) and flight tested with
steady and dynamic manoeuvres. Aerobatic dynamic manoeuvres were performed in flight
including a spin over a g-range â1g to +4g and demonstrated both the FBG and the EFFPI
instruments to have sufficient resolution to analyse the wing strain and fuselage unsteady
pressure characteristics. The steady manoeuvres from the EFFPI sensor matched the wind
tunnel data to within experimental error while comparisons of the flight test and wind tunnel
EFFPI results with a Kulite pressure sensor showed significant discrepancies between the two
sets of data, greater than experimental error. This issue is discussed further in the paper
Development of the Cranfield University Bulldog Flight Test Facility
Cranfield Universityâs National Flying Laboratory Centre (NFLC) has developed a Bulldog light aircraft into a flight test facility. The facility is being used to research advanced in-flight instrumentation including fibre optic pressure and strain sensors. During the development of the test bed, computational fluid dynamics (CFD) has been used to assist the flight test design process, including the sensor requirements. This paper describes the development of the Bulldog flight test facility, including an overview of the design and certification process, the in-flight data taken using the installed fibre optic sensor systems and lessons learned from the development programme, including potential further applications of the sensors
Comparison of LHC collimator beam-based alignment to BPM-interpolated centers
The beam centers at the Large Hadron Collider collimators are determined by beam-basedalignment, where both jaws of a collimator are moved in separately until a loss spike isdetected on a Beam Loss Monitor downstream. Orbit drifts of more than a few hundredmicrometers cannot be tolerated, as they would compromise the performance of thecollimation system. Beam Position Monitors (BPMs) are installed at various locations aroundthe LHC ring, and a linear interpolation of the orbit can be obtained at the collimatorpositions. In this paper, the results obtained from beam-based alignment are compared withthe orbit interpolated from the BPM data throughout the 2011 and 2012 LHC proton runs.Louisiana State University (LSU),U.S. Department of Energy, Office of Science,COSYLAB,DIMTEL,Muons, Inc.peer-reviewe
Interactions among genes in the ErbB-Neuregulin signalling network are associated with increased susceptibility to schizophrenia
<p>Abstract</p> <p>Background</p> <p>Evidence of genetic association between the NRG1 (Neuregulin-1) gene and schizophrenia is now well-documented. Furthermore, several recent reports suggest association between schizophrenia and single-nucleotide polymorphisms (SNPs) in ERBB4, one of the receptors for Neuregulin-1. In this study, we have extended the previously published associations by investigating the involvement of all eight genes from the ERBB and NRG families for association with schizophrenia.</p> <p>Methods</p> <p>Eight genes from the ERBB and NRG families were tested for association to schizophrenia using a collection of 396 cases and 1,342 blood bank controls ascertained from Aberdeen, UK. A total of 365 SNPs were tested. Association testing of both alleles and genotypes was carried out using the fast Fisher's Exact Test (FET). To understand better the nature of the associations, all pairs of SNPs separated by â„ 0.5 cM with at least nominal evidence of association (<it>P </it>< 0.10) were tested for evidence of pairwise interaction by logistic regression analysis.</p> <p>Results</p> <p>42 out of 365 tested SNPs in the eight genes from the ERBB and NRG gene families were significantly associated with schizophrenia (<it>P </it>< 0.05). Associated SNPs were located in ERBB4 and NRG1, confirming earlier reports. However, novel associations were also seen in NRG2, NRG3 and EGFR. In pairwise interaction tests, clear evidence of gene-gene interaction was detected for NRG1-NRG2, NRG1-NRG3 and EGFR-NRG2, and suggestive evidence was also seen for ERBB4-NRG1, ERBB4-NRG2, ERBB4-NRG3 and ERBB4-ERBB2. Evidence of intragenic interaction was seen for SNPs in ERBB4.</p> <p>Conclusion</p> <p>These new findings suggest that observed associations between NRG1 and schizophrenia may be mediated through functional interaction not just with ERBB4, but with other members of the NRG and ERBB families. There is evidence that genetic interaction among these loci may increase susceptibility to schizophrenia.</p
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Further evidence for the involvement of EFL1 in a Shwachman-Diamond-like syndrome and expansion of the phenotypic features.
Recent evidence has implicated EFL1 in a phenotype overlapping Shwachman-Diamond syndrome (SDS), with the functional interplay between EFL1 and the previously known causative gene SBDS accounting for the similarity in clinical features. Relatively little is known about the phenotypes associated with pathogenic variants in the EFL1 gene, but the initial indication was that phenotypes may be more severe, when compared with SDS. We report a pediatric patient who presented with a metaphyseal dysplasia and was found to have biallelic variants in EFL1 on reanalysis of trio whole-exome sequencing data. The variant had not been initially reported because of the research laboratory's focus on de novo variants. Subsequent phenotyping revealed variability in her manifestations. Although her metaphyseal abnormalities were more severe than in the original reported cohort with EFL1 variants, the bone marrow abnormalities were generally mild, and there was equivocal evidence for pancreatic insufficiency. Despite the limited number of reported patients, variants in EFL1 appear to cause a broader spectrum of symptoms that overlap with those seen in SDS. Our report adds to the evidence of EFL1 being associated with an SDS-like phenotype and provides information adding to our understanding of the phenotypic variability of this disorder. Our report also highlights the value of exome data reanalysis when a diagnosis is not initially apparent
What makes you not a Sikh? : a preliminary mapping of values
This study sets out to establish which Sikh values contrasted with or were shared by non-Sikh adolescents. A survey of attitude toward a variety of Sikh values was fielded in a sample of 364 non-Sikh schoolchildren aged between 13 and 15 in London. Values where attitudes were least positive concerned Sikh duties/code of conduct, festivals, rituals, prayer Gurdwara attendance, listening to scripture recitation, the amrit initiation. Sikh values empathized with by non-Sikhs concerned family pride, charity, easy access to ordination and Gurdwaras, maintaining the five Ks, seeing God in all things, abstaining from meat and alcohol and belief in the stories of Guru Nanak. Further significant differences of attitude toward Sikhism were found in comparisons by sex, age and religious affiliation. Findings are applied to teaching Sikhism to pupils of no faith adherence. The study recommends the extension of values mapping to specifically Sikh populations
The Ultraviolet Imaging Telescope: Instrument and Data Characteristics
The Ultraviolet Imaging Telescope (UIT) was flown as part of the Astro
observatory on the Space Shuttle Columbia in December 1990 and again on the
Space Shuttle Endeavor in March 1995. Ultraviolet (1200-3300 Angstroms) images
of a variety of astronomical objects, with a 40 arcmin field of view and a
resolution of about 3 arcsec, were recorded on photographic film. The data
recorded during the first flight are available to the astronomical community
through the National Space Science Data Center (NSSDC); the data recorded
during the second flight will soon be available as well. This paper discusses
in detail the design, operation, data reduction, and calibration of UIT,
providing the user of the data with information for understanding and using the
data. It also provides guidelines for analyzing other astronomical imagery made
with image intensifiers and photographic film.Comment: 44 pages, LaTeX, AAS preprint style and EPSF macros, accepted by PAS
A Pair of Compact Red Galaxies at Redshift 2.38, Immersed in a 100 kpc Scale Ly-alpha Nebula
We present Hubble Space Telescope (HST) and ground-based observations of a
pair of galaxies at redshift 2.38, which are collectively known as 2142-4420 B1
(Francis et al. 1996). The two galaxies are both luminous extremely red objects
(EROs), separated by 0.8 arcsec. They are embedded within a 100 kpc scale
diffuse Ly-alpha nebula (or blob) of luminosity ~10^44 erg/s.
The radial profiles and colors of both red objects are most naturally
explained if they are young elliptical galaxies: the most distant yet found. It
is not, however, possible to rule out a model in which they are abnormally
compact, extremely dusty starbursting disk galaxies. If they are elliptical
galaxies, their stellar populations have inferred masses of ~10^11 solar masses
and ages of ~7x10^8 years. Both galaxies have color gradients: their centers
are significantly bluer than their outer regions. The surface brightness of
both galaxies is roughly an order of magnitude greater than would be predicted
by the Kormendy relation. A chain of diffuse star formation extending 1 arcsec
from the galaxies may be evidence that they are interacting or merging.
The Ly-alpha nebula surrounding the galaxies shows apparent velocity
substructure of amplitude ~ 700 km/s. We propose that the Ly-alpha emission
from this nebula may be produced by fast shocks, powered either by a galactic
superwind or by the release of gravitational potential energy.Comment: 33 pages, 9 figures, ApJ in press (to appear in Jun 10 issue
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