7 research outputs found
Spondylarthrite ankylosante au Sénégal: aspects épidémiologiques, diagnostiques, thérapeutiques et évolutifs au Centre Hospitalier Universitaire Aristide LeDantec de Dakar
Introduction: la spondylarthrite ankylosante (SA) est une maladie évolutive, pouvant s'aggraver par une invalidité. Le but de notre étude est de décrire les aspects épidémiologiques, diagnostiques, thérapeutiques et évolutifs de la SA dans le service de rhumatologie du Centre Hospitalier Universitaire Aristide LeDantec à Dakar.
Méthodes: il s´agissait d´une étude transversale descriptive et analytique, avec un recueil de données à la fois prospectif et rétrospectif sur une période de 8 ans, entre janvier 2012 et décembre 2020, sur des patients atteints de SA de diagnostic établi en accord avec les critères diagnostiques d´Amor, de l´ESSG (European Seronegative Spondylarthropathy Group), d´ASAS (Assessment of Spondyloarthritis International Society) et les critères de New York modifié pour la SA. Les données ont été recueillies par le biais d'un questionnaire structuré et analysées à l´aide du logiciel SPSS25 (Statistical Package for the Social Sciences).
Résultats: six cent quarante-sept (647) patients ont répondu aux critères d´inclusions; 414 femmes et 233 hommes soit un sex ratio de 1,77F/1H. Différentes formes symptomatiques étaient obtenues: les formes axiales (55,65%), les formes mixtes (44,35%) et les formes systémiques avec manifestation extra-articulaires: uvéites (12,21%), insuffisance aortique (5,71%) et maladie fibrobulleuse des poumons (3,86%). Soixante pourcent (60%) des patients étaient sous antiinflammatoires non stéroïdiens (AINS), 47% sous méthotrexate et 0,92% sous biothérapie. Les indices d´activité de la maladie, les indices fonctionnels et les indices de la qualité de vie ont permis le suivi de la maladie.
Conclusion: nos résultats ont montré une prédominance féminine. Les formes axiales étaient les plus représentées. Plus de la moitié de nos patients étaient sous antiinflammatoires, 47% sous méthotrexate et 0,92% sous biothérapie. Cette étude a permis de comprendre le poids de la SA dans les spondyloarthrites et son évolution dans le temps
Rhupus : Étude de Deux Observations à Conakry, Guinée
Rhupus is a combination of RA and SLE clinical manifestations. It is a rare clinical entity which still remains controversial. We reported two (2) clinical cases which illustrate its existence by taking into account the review of medical literature. The diagnosis of both diseases was reached according to 2010 EULAR (European League Against Rheumatism)/ACR (American College of Rheumatology) classification criteria for RA and the 1997 ACR classification criteria for SLE. Although it is rare, the association of the two diseases is a real entity.Le rhupus est une association de polyarthrite rhumatoïde et de lupus érythémateux systémique. Il s’agit d’une entité clinique rare qui reste controversée. Nous en rapportons deux nouvelles observations de patients chez un homme de 48 ans et une femme de 26 ans qui illustrent, en confrontation avec les données de la littérature, la réalité de son existence. Le diagnostic de PR (Polyarthrite rhumatoïde) et de LES (lupus érythémateux systémique) était porté sur des arguments cliniques et paracliniques en accord avec les critères ACR (American College of Rheumatology) / EULAR (European League Against Rheumatism) 2010 pour la PR et ACR 1997 pour le LES. L’association de la polyarthrite rhumatoïde et du lupus est rare mais réelle
Spondyloarthrites au Sénégal: Étude de 350 Observations
Objective: Spondyloarthritis is classically considered rare in subSaharan Africa where the majority of the population is considered to be HLAB27 negative. Thus, this series allows us to describe the characteristics of SpA in one Senegalese hospital. Patients and methods: Retrospective and descriptive study carried out in the Rheumatology Department of the University Hospital of Dakar. The diagnosis of SpA was retained in accordance with the ASAS and modified New York criteria. For each patient, the following data were collected: age, sex, time to diagnosis, type of SpA, nature of joint involvement: axial, peripheral, extra-articular manifestations, HLA B27 phenotyping. Results: 350 observations of SpA were collected in 228 women (65%) with a mean age of 47 ± 13. The average time to diagnosis was 11 years. AS was the most common: 71.2%, reactive arthritis 8.3%, psoriatic arthritis 6%, IBD 2.6%, SAPHO and undifferentiated forms 2.7%. HLA B 27 phenotyping was performed in 213 patients, 115 patients were HLA B27 positive (50.7%). Treatment was based on nonsteroidal antiinflammatory drugs (47.71%). Conclusion: SpA is growing in a Senegalese hospital. They hit especially the middle aged woman of 46 years old. AS is the most common form of SpA. HLA B27 is present in about in 1 out of 2 patients.Objectif: Les spondyloarthrites sont classiquement considérées comme rares en Afrique sub-saharienne où la majorité de la population est considérée comme HLA-B27 négatif. L’objectif de notre étude était de décrire les caractéristiques des SpA en milieu hospitalier sénégalais. Patients et méthode: Ils’agissait d’une étude rétrospective réalisée dans le service de rhumatologie du CHU Le Dantec de Dakar. Le diagnostic de SpA était retenu en accord avec les critères d’ASAS et de New York modifié. Pour chaque patient, les données suivantes ont été collectées : l’âge, le sexe, le délai au diagnostic, le type de SpA, la nature de l’atteinte articulaire : axiale, périphérique, manifestations extra-articulaires, le phénotypage HLA B27. Résultats: Avaient été colligées 350 observations de SpA chez 228 femmes (65 %) d’âges moyen de 47 ±13 ans. Le délai moyen au diagnostic était de 11 ans. La SA était la plus fréquente : 71,2 %, ARé 8,3 %, le RP 6 %, les MICI 2,6 %, le SAPHO et les formes indifférenciées 2,7 %. Le phénotypage HLA B 27 était réalisé chez 213 patients, 115 patients étaient HLA B27 positifs (50,7%). Le traitement était basé sur les AINS (47,71%). Conclusion : Les SpA sont en croissance en milieu hospitalier Sénégalais. Elles sont surtout fréquentes chez la femme. La SA est la SpA la plus fréquente et l’antigène HLA B27 est présente chez environ 1 patient sur 2
Evaluation of the pulse wave velocity in African rheumatoid arthritis subjects
Background: Rheumatoid arthritis is a systemic disease with often fatal vascular events. In addition to traditional cardiovascular risk factors, disease-specific elements contribute to this cardiovascular mortality. The aim of this study was to assess arterial stiffness in rheumatoid arthritis and to determine the factors involved.Methods: We have recruited the black African patients followed in rheumatology and had rheumatoid arthritis diagnosis. Only patients between 18 and 60 years and meeting the American College of Rheumatology criteria were included. All controls were healthy. We evaluated the propagation velocity of the pulse wave finger-toe (PWVft) measured by the pOpmètre®.Results: Present study shows that the PWVft was significantly elevated in over half of patients (55.10%). Besides, the mean patients PWVft was significantly higher than that of the control (respectively 9.40±0.51 and 7.22±0.33 p=0.001). In the patients, no factor was significantly involved in the arterial stiffness, but cons in the control group, the PWVft was significantly correlated with age (p=0.023 and r=0.55).Conclusions: Rheumatoid arthritis patients had higher PWVft compared to controls. Due to the importance of its cardiovascular morbidity and mortality, arthritis requires a regular monitoring element as arterial stiffness, which is currently a major vascular parameter monitoring
Epidemiological, clinical and immunological aspects of antisynthetase syndrome: a multicentre study in Dakar
Evaluation of the pulse wave velocity in African rheumatoid arthritis subjects
Background: Rheumatoid arthritis is a systemic disease with often fatal vascular events. In addition to traditional cardiovascular risk factors, disease-specific elements contribute to this cardiovascular mortality. The aim of this study was to assess arterial stiffness in rheumatoid arthritis and to determine the factors involved.Methods: We have recruited the black African patients followed in rheumatology and had rheumatoid arthritis diagnosis. Only patients between 18 and 60 years and meeting the American College of Rheumatology criteria were included. All controls were healthy. We evaluated the propagation velocity of the pulse wave finger-toe (PWVft) measured by the pOpmètre®.Results: Present study shows that the PWVft was significantly elevated in over half of patients (55.10%). Besides, the mean patients PWVft was significantly higher than that of the control (respectively 9.40±0.51 and 7.22±0.33 p=0.001). In the patients, no factor was significantly involved in the arterial stiffness, but cons in the control group, the PWVft was significantly correlated with age (p=0.023 and r=0.55).Conclusions: Rheumatoid arthritis patients had higher PWVft compared to controls. Due to the importance of its cardiovascular morbidity and mortality, arthritis requires a regular monitoring element as arterial stiffness, which is currently a major vascular parameter monitoring
Prevalence and impact of adiposity and sarcopenia during rheumatoid arthritis: rapid and non-invasive evaluation in Sub-Saharan African women
Background: Body composition plays a fundamental role in the occurrence of complications in rheumatoid arthritis. Authors conducted this study, which aimed to determine body composition and its effects on physiological status in African sub-Saharan polyarthritis women.Methods: The anthropometric parameters were measured after an interview and a complete physical examination. The body composition was evaluated using a Tanita® brand bioimpedance meter. Finally, all the patients had a dosage of certain biochemical parameters.Results: An excess of percent fat mass was noted in more than half of women (59.52%) without loss of muscle mass. At the same time, 30% of women had a significant decrease in the percentage of body water. The BMI did not appear to be an adequate proxy for these changes. Visceral fat level was elevated just in 16% of women, however it would be a determinant of physiological aging of subjects. Dual therapy methotrexate and corticosteroid would have varying effects depending on the duration and the dose of treatment. The basic metabolism in polyarthritic subjects would be dependent on two parameters namely muscle mass and inflammatory state.Conclusions: Evaluating changes in body composition quickly, non-invasively and inexpensively is possible. It could be useful in the follow-up of rheumatoid arthritis. Managing these changes can reduce cardiovascular morbidity and mortality in rheumatoid arthritis