PCDD/Fs in sediments of Central Vietnam coastal lagoons: In search of TCDD

Samples from nine Central Vietnam coastal lagoons, together with three soils and sediments collected in 24 two freshwater reservoirs of the Thua Thien-Hué province, were analysed for polychlorinated dibenzo-p- 25 dioxins and dibenzofurans (PCDD/Fs). Total concentrations are low, from 192 to 2912 pg g1 and depth 26 profiles in Tam Giang-Cau Hai (TG-CH) sediment cores show only minor changes over time in PCDD/F 27 input and composition. Octachloro dibenzo-p-dioxin (OCDD) is the prevailing congener (approximately 28 90%), indicating combustion as the main PCDD/F source to these coastal systems, whereas natural forma- 29 tion might be partly responsible for the presence at depth. 2,3,7,8-Tetrachloro dibenzo-p-dioxin (TCDD), 30 largely sprayed together with Agent Orange over the study areas during the war (1961–1971), is absent 31 or very low. This result supports the hypothesis of strong degradation soon after spraying. Multivariate 32 statistical analyses account for the presence of local, short-range sources as observed in the northern part 33 of the TG-CH lagoon

PBDEs and PCBs in sediments of the Thi Nai Lagoon (Central Vietnam) and soils from its mainland

Concentration and distribution of PCBs, PCB 11, and PBDEs in both surficial sediment and soil samples, taken from a zone subject to recent accelerated development, were investigated to assess the environmental quality and understand both natural and anthropogenic processes that influence contaminant behaviors. Values of PCB and PBDE are in the lower range of those reported in literature, typical of low impacted coastal zones. This could be due to efficient processes of resuspension and removal. Contaminants in the lagoon showed higher concentrations in sediments from sites close to the city and the outfalls of the industrial area, while soils showed maximum values in the northern samples. In addition, congener patterns and statistical analyses suggest the presence of effective degradation processes, especially for PBDEs, with the exception of the most concentrated samples that may indicate a direct input. PCB 11 is a significant component (up to 18%) in most lagoon sediments. Its presence is strongly associated with fine particles, thus the distribution seems to be driven mainly by the system hydrodynamic and does not trace the sources. Due to evaporation, only flooded agricultural soils show a similar relative abundance of this congener

小児重症デング熱発症前早期バイオマーカー候補分子のプロテオーム解析による同定

Background: Severe dengue with severe plasma leakage (SD-SPL) is the most frequent of dengue severe form. Plasma biomarkers for early predictive diagnosis of SD-SPL are required in the primary clinics for the prevention of dengue death. Methodology: Among 63 confirmed dengue pediatric patients recruited, hospital based longitudinal study detected six SD-SPL and ten dengue with warning sign (DWS). To identify the specific proteins increased or decreased in the SD-SPL plasma obtained 6?48 hours before the shock compared with the DWS, the isobaric tags for relative and absolute quantification (iTRAQ) technology was performed using four patients each group. Validation was undertaken in 6 SD-SPL and 10 DWS patients. Principal findings: Nineteen plasma proteins exhibited significantly different relative concentrations (p<0.05), with five over-expressed and fourteen under-expressed in SD-SPL compared with DWS. The individual protein was classified to either blood coagulation, vascular regulation, cellular transport-related processes or immune response. The immunoblot quantification showed angiotensinogen and antithrombin III significantly increased in SD-SPL whole plasma of early stage compared with DWS subjects. Even using this small number of samples, antithrombin III predicted SD-SPL before shock occurrence with accuracy. Conclusion: Proteins identified here may serve as candidate predictive markers to diagnose SD-SPL for timely clinical management. Since the number of subjects are small, so further studies are needed to confirm all these biomarkers.長崎大学学位論文 学位記番号:博(医歯薬)甲第862号 学位授与年月日:平成28年3月18日Author: Dang My Nhi, Nguyen Tien Huy, Kaname Ohyama, Daisuke Kimura, Nguyen Thi Phuong Lan, Leo Uchida, Nguyen Van Thuong, Cao Thi My Nhon, Le Hong Phuc, Nguyen Thi Mai, Shusaku Mizukami, Lam Quoc Bao, Nguyen Ngoc Doan, Nguyen Van Thanh Binh, Luong Chan Quang, Juntra Karbwang, Katsuyuki Yui, Kouichi Morita, Vu Thi Que Huong, Kenji HirayamaCitation: PLoS Neglected Tropical Diseases, 10(2), e0004435; 2016Nagasaki University (長崎大学)課程博